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Integrated Continuous Process Design for Crystallisation, Spherical Agglomeration, and Filtration of Lovastatin
PurposeThis work seeks to improve the particle processability of needle-like lovastatin crystals and develop a small-footprint continuous...
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Lovastatin inhibits erythroleukemia progression through KLF2-mediated suppression of MAPK/ERK signaling
BackgroundLovastatin, an HMG-CoA inhibitor and an effective cholesterol lowering drug, exhibits anti-neoplastic activity towards several types of...
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Suppressive role of lovastatin in intracerebral hemorrhage through repression of autophagy
Statins possess critical function in the brain. Here, we intended to investigate the role of lovastatin in brain damage after intracerebral...
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Understanding the “individual drug reaction” from the perspective of the interaction between probiotics and lovastatin in vitro and in vivo
BackgroundThe existence of the gut microbiota produces an “individual drug reaction.” As members of the intestinal microbiota, probiotics, although...
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AGR2-induced cholesterol synthesis drives lovastatin resistance that is overcome by combination therapy with allicin
Anterior gradient 2 (AGR2), a protein disulfide isomerase (PDI), is a multifunctional protein under physiological and pathological conditions. In...
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Complex interactions of lovastatin with 10 chemotherapeutic drugs: a rigorous evaluation of synergism and antagonism
BackgroundEvidence bearing on the role of statins in the prevention and treatment of cancer is confounded by the diversity of statins,...
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Design and Development of Solid SMEDDS and Liquisolid Formulations of Lovastatin, for Improved Drug Dissolution and In vivo Effects—a Pharmacokinetic and Pharmacodynamic Assessment
Lovastatin (Lov) is a lipid-lowering agent, with 5% bioavailability (BA) due to extensive first pass metabolism and poor solubility. To enhance...
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Autophagy inhibitors increase the susceptibility of KRAS-mutant human colorectal cancer cells to a combined treatment of 2-deoxy-D-glucose and lovastatin
RAS-driven colorectal cancer relies on glucose metabolism to support uncontrolled growth. However, monotherapy with glycolysis inhibitors like...
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Novel compounds isolated from health food products containing beni-koji (red yeast rice) with adverse event reports
Recently, health hazards, such as kidney damage, have been reported owing to the ingestion of a health food product, so-called “foods with functional...
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Controlled trial of lovastatin combined with an open-label treatment of a parent-implemented language intervention in youth with fragile X syndrome
BackgroundThe purpose of this study was to conduct a 20-week controlled trial of lovastatin (10 to 40 mg/day) in youth with fragile X syndrome (FXS)...
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Long-term outcomes of statin dose, class, and use intensity on primary prevention of cardiovascular mortality: a national T2DM cohort study
PurposeTo investigate how statins reduce cardiovascular mortality in patients with type 2 diabetes (T2DM) in a dose-, class-, and use...
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Biological Activities of Some Edible Mushrooms
Since ancient times, mushrooms have been a valuable food source and traditional medicine worldwide. Edible mushrooms possess high nutritional value...
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Neuroprotective effects of lovastatin in the pilocarpine rat model of epilepsy according to the expression of neurotrophic factors
Studies have suggested that neurotrophic factors (NTFs) are involved in the status epilepticus development. This indicates their essential role in...
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Kinome-wide analysis of the effect of statins in colorectal cancer
BackgroundEpidemiological studies and meta-analyses show an association between statin use and a reduced incidence of colorectal cancer (CRC). We...
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Cholesterol promotes EGFR-TKIs resistance in NSCLC by inducing EGFR/Src/Erk/SP1 signaling-mediated ERRα re-expression
BackgroundThe use of epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) brings remarkable benefits for the survival of patients...
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Combining familial hypercholesterolemia and statin genetic studies as a strategy for the implementation of pharmacogenomics. A multidisciplinary approach
The diagnostic process of familial hypercholesterolemia frequently involves the use of genetic studies. Patients are treated with lipid-lowering...
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Diagnosis and Drug Prediction of Parkinson’s Disease Based on Immune-Related Genes
Parkinson’s disease (PD) is the second most common neurodegenerative disorder. Immune mechanisms play an important role in the development of PD. The...
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Evaluation of Piperine as Natural Coformer for Eutectics Preparation of Drugs Used in the Treatment of Cardiovascular Diseases
Piperine (PIP) was evaluated as a natural coformer in the preparation of multicomponent organic materials for enhancing solubility and dissolution...
