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Preparation of semaglutide long-acting injectable microcapsules with physicochemical properties, long-term stability, and pharmacokinetics and pharmacodynamics
PurposeTo develop once-a-month long acting semaglutide injectable, its manufacturing process was optimized. The final product to be selected based on...
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Long-term stability of single neuron activity in the motor system
How an established behavior is retained and consistently produced by a nervous system in constant flux remains a mystery. One possible solution to...
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Long-term climatic stability drives accumulation and maintenance of divergent freshwater fish lineages in a temperate biodiversity hotspot
Anthropogenic climate change is forecast to drive regional climate disruption and instability across the globe. These impacts are likely to be...
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Long-Term Measurements
Long-term measurements in slice electrophysiology typically constitute long-term potentiation (LTP)Long-term potentiation (LTP) and long-term...
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Short-term exposure to antibiotics begets long-term disturbance in gut microbial metabolism and molecular ecological networks
BackgroundAntibiotic exposure can occur in medical settings and from environmental sources. Long-term effects of brief antibiotic exposure in early...
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A self-amplifying RNA vaccine against COVID-19 with long-term room-temperature stability
mRNA vaccines were the first to be authorized for use against SARS-CoV-2 and have since demonstrated high efficacy against serious illness and death....
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Long-Term Potentiation
At many glutamatergic synapses in the brain, brief episodes of strong synaptic activity can lead to an enduring enhancement of synaptic strength, a...
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Accelerated Stability Assessment Program to Predict Long-term Stability of Drugs: Application to Ascorbic Acid and to a Cyclic Hexapeptide
During pharmaceutical development, the stability of the product is assessed during long-term study. If any stability issues are discovered at this...
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Hyaluronic acid spacer in prostate cancer radiotherapy: dosimetric effects, spacer stability and long-term toxicity and PRO in a phase II study
BackgroundPerirectal spacers may be beneficial to reduce rectal side effects from radiotherapy (RT). Here, we present the impact of a hyaluronic acid...
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Long-term Storage Stability Assessment of Omega-3-Fatty Acid Emulsified Formulation Containing Micronutrients
PurposeRole of omega-3 fatty acid (ω-3 FA) in human health and negative impact of altered omega-6 to 3 ratio is well documented. Hence, food...
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Clinical characteristics and long-term neurodevelopmental outcomes of leukomalacia in preterm infants and term infants: a cohort study
BackgroundLeukomalacia is a serious form of neonatal brain injury that often leads to neurodevelopmental impairment, and studies on neonatal...
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Vacuum Foam Drying Method Improved the Thermal Stability and Long-Term Shelf Life of a Live Attenuated Newcastle Disease Virus Vaccine
Vaccines used for managing Newcastle disease virus (NDV) rely heavily on cold chain, and this results in major constraints in their successful...
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Long-term memory for spatial frequency: a non-replication
Reports on stability of spatial frequency in short-term memory span have confirmed low-level perceptual memory mechanism in early visual processing....
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Early Environment and Telomeres: a Long-Term Toxic Relationship
Purpose of ReviewTelomere length (TL) shortening is a hallmark of biological aging. While studies have extensively focused on the impact of...
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Long-term and real-world safety and efficacy of retroviral gene therapy for adenosine deaminase deficiency
Adenosine deaminase (ADA) deficiency leads to severe combined immunodeficiency (SCID). Previous clinical trials showed that autologous CD34 + cell...
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Structural underpinnings and long-term effects of resilience in Parkinson’s disease
Resilience in neuroscience generally refers to an individual’s capacity to counteract the adverse effects of a neuropathological condition. While...
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Tailored surgery on aggressive osteoblastoma involving the cervicothoracic junction: an oncological and spinal stability long-term follow-up
IntroductionAggressive osteoblastoma (AO) represents a rare tumor with borderline features between benign osteoblastoma and osteosarcoma. Having a...
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Prefrontal engrams of long-term fear memory perpetuate pain perception
A painful episode can lead to a life-long increase in an individual’s experience of pain. Fearful anticipation of imminent pain could play a role in...
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Long-term severe hypoxia adaptation induces non-canonical EMT and a novel Wilms Tumor 1 (WT1) isoform
The majority of cancer deaths are caused by solid tumors, where the four most prevalent cancers (breast, lung, colorectal and prostate) account for...
