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Design of a Liver-on-a-Chip
An organ-on-a-chip is a microscale rigid plate (therefore, called a chip) containing the specialized cells of a given tissue and a fluid line flowing...
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Liver-on-a-Chip
Hepatotoxicity preclinical experiments using animal models have many limitations such as time consuming, expensive, and mismatching cross-species...
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Functional integration of natural killer cells in a microfluidically perfused liver on-a-chip model
ObjectiveThe liver acts as an innate immunity-dominant organ and natural killer (NK) cells, are the main lymphocyte population in the human liver. NK...
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State-of-the-art liver disease research using liver-on-a-chip
To understand disease pathophysiologies, models that recapitulate human functions are necessary. In vitro models that consist of human cells are...
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Novel application of live imaging to determine the functional cell biology of endothelial-to-mesenchymal transition (EndMT) within a liver-on-a-chip platform
ObjectiveImaging endothelial cell behaviour under physiological conditions, particularly those associated with chronic fibrotic pathologies, is an...
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Emergence of In Vitro 3D Systems to Model Human Malaria
This book illustrates the importance and advances of the disease model for malaria, a globally affected public health problem. This book provides...
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Microfluidic design for in-vitro liver zonation—a numerical analysis using COMSOL Multiphysics
The liver is one of the most important organs, with a complex physiology. Current in-vitro approaches are not accurate for disease modeling and drug...
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Quantitative imaging of doxorubicin diffusion and cellular uptake in biomimetic gels with human liver tumor cells
Novel tumor-on-a-chip approaches are increasingly used to investigate tumor progression and potential treatment options. To improve the effect of any...
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LncRNA H19-EZH2 interaction promotes liver fibrosis via reprogramming H3K27me3 profiles
Liver fibrosis is a wound-healing process characterized by excess formation of extracellular matrix (ECM) from activated hepatic stellate cells...
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Implementing organ-on-chip in a next-generation risk assessment of chemicals: a review
Organ-on-chip (OoC) technology is full of engineering and biological challenges, but it has the potential to revolutionize the Next-Generation Risk...
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Epigenetic reprogramming-induced guanidinoacetic acid synthesis promotes pancreatic cancer metastasis and transcription-activating histone modifications
BackgroundPancreatic ductal adenocarcinoma (PDAC) tends to undergo distant metastasis, especially liver metastasis, leading to a poor prognosis....
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Introducing CELLBLOKS®: a novel organ-on-a-chip platform allowing a plug-and-play approach towards building organotypic models
Human organs are structurally and functionally complex systems. Their function is driven by the interactions between many specialised cell types,...
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Microfluidic Chip as a Tool for Effective In Vitro Evaluation of Cyclophosphamide Prodrug Toxicity
Most drugs are metabolized in the liver, which can lead to their activation or inactivation with a change in the parent compound pharmacology, as...
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Swimming exercise ameliorates insulin resistance and nonalcoholic fatty liver by negatively regulating PPARγ transcriptional network in mice fed high fat diet
BackgroundRecent findings elucidated hepatic PPARγ functions as a steatogenic-inducer gene that activates de novo lipogenesis, and is involved in...
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ACLY as a modulator of liver cell functions and its role in Metabolic Dysfunction-Associated Steatohepatitis
BackgroundNon-alcoholic Fatty Liver Disease (NAFLD), now better known as Metabolic (Dysfunction)-Associated Fatty Liver Disease (MAFLD) and its...
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E2F1 combined with LINC01004 super-enhancer to promote hepatocellular carcinoma cell proliferation and metastasis
IntroductionSuper-enhancer-associated lncRNAs play important roles in the occurrence and development of malignant tumors, including hepatocellular...
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A Novel Milli-fluidic Liver Tissue Chip with Continuous Recirculation for Predictive Pharmacokinetics Applications
A crucial step in lead selection during drug development is accurate estimation and optimization of hepatic clearance using in vitro methods....
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LncRNA CALML3-AS1 modulated by m6A modification induces BTNL9 methylation to drive non-small-cell lung cancer progression
Non-small cell lung cancer (NSCLC) is a common and lethal malignancy. The carcinogenic roles of lncRNA CALML3 antisense RNA 1 (CALML3-AS1) have been...
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The p-STAT3/ANXA2 axis promotes caspase-1-mediated hepatocyte pyroptosis in non-alcoholic steatohepatitis
BackgroundTo explore the roles of Annexin A2 (ANXA2) on hepatocyte pyroptosis and hepatic fibrosis in nonalcoholic steatohepatitis (NASH) and...
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In vitro grafting of hepatic spheroids and organoids on a microfluidic vascular bed
With recent progress in modeling liver organogenesis and regeneration, the lack of vasculature is becoming the bottleneck in progressing our ability...
