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Defining type 2 diabetes polygenic risk scores through colocalization and network-based clustering of metabolic trait genetic associations
BackgroundType 2 diabetes (T2D) is a heterogeneous and polygenic disease. Previous studies have leveraged the highly polygenic and pleiotropic nature...
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Association between genetically proxied lipid-lowering drug targets, lipid traits, and amyotrophic lateral sclerosis: a mendelian randomization study
BackgroundThe use of circulating lipid traits as biomarkers to predict the risk of amyotrophic lateral sclerosis (ALS) is currently controversial,...
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Genetic association of lipid traits and lipid-related drug targets with normal tension glaucoma: a Mendelian randomization study for predictive preventive and personalized medicine
BackgroundGlaucoma is the leading cause of irreversible blindness worldwide. Normal tension glaucoma (NTG) is a distinct subtype characterized by...
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Association of lipid-lowering drug targets with risk of cutaneous melanoma: a mendelian randomization study
BackgroundMelanoma proliferation is partly attributed to dysregulated lipid metabolism. The effectiveness of lipid-lowering drugs in combating...
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Cell-type-specific and disease-associated expression quantitative trait loci in the human lung
Common genetic variants confer substantial risk for chronic lung diseases, including pulmonary fibrosis. Defining the genetic control of gene...
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Repurposing lipid-lowering drugs on asthma and lung function: evidence from a genetic association analysis
ObjectiveTo explore the correlation between asthma risk and genetic variants affecting the expression or function of lipid-lowering drug targets.
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EXO1/P53/SREBP1 axis-regulated lipid metabolism promotes prostate cancer progression
Prostate cancer (PCa) is one of the most common malignant tumors affecting the male genitourinary system. However, there is currently a lack of...
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MEF2C regulates NK cell effector functions through control of lipid metabolism
Natural killer (NK) cells are a critical first line of defense against viral infection. Rare mutations in a small subset of transcription factors can...
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Novel autosomal dominant TMC1 variants linked to hearing loss: insight into protein-lipid interactions
BackgroundTMC1 , which encodes transmembrane channel-like protein 1, forms the mechanoelectrical transduction (MET) channel in auditory hair cells,...
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Drug Delivery Systems: Lipid Nanoparticles Technology in Clinic
Drug delivery systems (DDS) aid the administration of therapeutic cargoes to desired tissues to evoke a pharmacological response with minimal adverse...
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Discovery and Exploration of Lipid-Modifying Drug Targets for ALS by Mendelian Randomization
Observational studies have faced challenges in identifying replicable causes for amyotrophic lateral sclerosis (ALS). To address this, we employed an...
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Circulating lipids, lipid-lowering drug targets, and breast cancer risk: Comprehensive evidence from Mendelian randomization and summary data-based Mendelian randomization
BackgroundBreast cancer (BC) is the most common and fatal cancer among women, yet the causal relationship between circulating lipids, lipid-lowering...
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Transcriptomics of differences in thermal plasticity associated with selection for an exaggerated male sexual trait
The information about the magnitude of differences in thermal plasticity both between and within populations, as well as identification of the...
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The combination of machine learning and untargeted metabolomics identifies the lipid metabolism -related gene CH25H as a potential biomarker in asthma
BackgroundLipids, significant signaling molecules, regulate a multitude of cellular responses and biological pathways in asthma which are closely...
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ACSL3 regulates lipid droplet biogenesis and ferroptosis sensitivity in clear cell renal cell carcinoma
BackgroundClear cell renal cell carcinoma (ccRCC), the predominant subtype of kidney cancer, possesses characteristic alterations to multiple...
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Whole-exome sequencing identifies novel protein-altering variants associated with serum apolipoprotein and lipid concentrations
BackgroundDyslipidemia is a major risk factor for cardiovascular disease, and diabetes impacts the lipid metabolism through multiple pathways. In...
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On the Feasibility of Rugose Lipid Microparticles in Pressurized Metered Dose Inhalers with Established and New Propellants
Pressurized metered dose inhalers (pMDIs) require optimized formulations to provide stable, consistent lung delivery. This study investigates the...
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Comprehensive analysis of bulk and single-cell transcriptomic data reveals a novel signature associated with endoplasmic reticulum stress, lipid metabolism, and liver metastasis in pancreatic cancer
BackgroundPancreatic ductal adenocarcinoma (PDAC) is a lethal malignancy with high probability of recurrence and distant metastasis. Liver metastasis...
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Cancer and Lipid Metabolism: Roles of Adipocytes on Tumor Microenvironment
The tumor microenvironment is a complex structure surrounding cancer cells with various cell types, involving stromal and immune cells, including...
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Super-Resolution Imaging of Intracellular Lipid Nanocarriers to Study Drug Delivery in Photodynamic Therapy
Liposomal nanocarriers are intensively investigated as delivery vehicles for photoactivatable agents used in photodynamic therapy (PDT). The uptake,...