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A Drug–Drug Interaction Study to Investigate the Effect of Nintedanib on the Pharmacokinetics of Microgynon (Ethinylestradiol and Levonorgestrel) in Female Patients with Systemic Sclerosis-Associated Interstitial Lung Disease
Background and ObjectivesNintedanib is a tyrosine kinase inhibitor approved for the treatment of systemic sclerosis-associated interstitial lung...
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Models and methods to characterise levonorgestrel release from intradermally administered contraceptives
Microneedle (MN)-based technologies have been proposed as a means to facilitate minimally invasive sustained delivery of long-acting hormonal...
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RP-HPLC method validation for fast extraction and quantification of Levonorgestrel drug from silicone based intrauterine device intended for in-process and finished formulation
BackgroundTo develop and validate a simple and consistent reversed phase high performance liquid chromatography (RP-HPLC) method for the estimation...
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Preparation, characterization, and in vivo evaluation of levonorgestrel-loaded thermostable microneedles
To facilitate the storage and use of poly (lactic-co-glycolic acid) (PLGA)-based microneedles (MNs) in hot seasons and regions, thermally stable MNs...
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Assessment of the Effects of Abrocitinib on the Pharmacokinetics of Probe Substrates of Cytochrome P450 1A2, 2B6 and 2C19 Enzymes and Hormonal Oral Contraceptives in Healthy Individuals
Background and ObjectiveAbrocitinib is an oral small-molecule Janus kinase (JAK)-1 inhibitor approved for the treatment of moderate-to-severe atopic...
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Association between the use of hormonal contraceptives and risk of cholecystectomy in women of reproductive age
PurposePrevious studies have indicated an increased risk of gallbladder disease with hormonal contraceptives although with discordant results. The...
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Risk of sexual dysfunction with progestin-based contraceptives in women of child-bearing age
PurposeTo examine whether there is a positive association between sexual dysfunction (SD) and different types of progestin-based contraceptives.
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Evaluation of pharmacological interventions in the management of adenomyosis: a systematic review
PurposeMedical management of adenomyosis largely revolves around symptom management, with very few drugs having received regulatory approval for the...
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Antiprogestins reduce epigenetic field cancerization in breast tissue of young healthy women
BackgroundBreast cancer is a leading cause of death in premenopausal women. Progesterone drives expansion of luminal progenitor cells, leading to...
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Oral ethinylestradiol-levonorgestrel attenuates cardiac glycogen and triglyceride accumulation in high fructose female rats by suppressing pyruvate dehydrogenase kinase-4
Fructose (FRU) intake has increased dramatically in recent decades with a corresponding increased incidence of insulin resistance (IR), particularly...
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The promise of microneedle technologies for drug delivery
Microneedle (MN) technologies offer the opportunity to improve patient access and target delivery of drugs and vaccines to specific tissues. When in...
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Patient involvement in pharmacovigilance: determinants and evolution of reporting from 2011 to 2020 in France
IntroductionBecause patients and patient organizations want to strengthen their role in the care pathway and drug evaluation and in order to improve...
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Application of Modeling and Simulation to Identify a Shortened Study Duration and Novel Bioequivalence Metric for a Long-Acting Intrauterine System
An intrauterine system (IUS) can be implanted in the uterus and deliver drug directly at the site of pharmacological action. Mirena was the first...
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Impact of hormonal contraception on endometrial histology in patients with Lynch syndrome, a retrospective pilot study
Hormonal contraception (HC) is a well-recognized protection against endometrial cancer (EC) in the general population. It has not been established if...
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The effect of laquinimod, a novel immuno-modulator in development to treat Huntington disease, on the pharmacokinetics of ethinylestradiol and levonorgestrel in healthy young women
PurposeLaquinimod is an orally dosed immuno-modulator currently under development for Huntington’s disease (HD). Preclinical findings suggest...
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The Impacts of Sex Differences and Sex Hormones on Fear Extinction
Fear extinction memories are strongly modulated by sex and hormonal status, but the exact mechanisms are still being discovered. In humans, there are...
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Prediction of complete regression in fertility-sparing patients with endometrial cancer and apical hyperplasia: the GLOBAL model in a large Chinese cohort
BackgroundFertility preservation treatment is increasingly essential for patients with apical endometrial hyperplasia (AEH) and early endometrial...
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Metformin and cancer hallmarks: shedding new lights on therapeutic repurposing
Metformin is a well-known anti-diabetic drug that has been repurposed for several emerging applications, including as an anti-cancer agent. It boasts...
