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C-type lectin 4 of Toxocara canis activates NF-ĸB and MAPK pathways by modulating NOD1/2 and RIP2 in murine macrophages in vitro
Toxocara canis is a parasitic zoonose that is distributed worldwide and is one of the two pathogens causing toxocariasis. After infection, it causes...
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Heating or ginger extract reduces the content of Pinellia ternata lectin in the raphides of Pinellia tuber
Pinellia tuber, the dried tuber of Pinellia ternata , causes a very strong acridity sensation in the oral and laryngopharynx mucosa when taken orally...
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Lectin Staining to Detect Human and Avian Influenza Virus Receptors in the Airway of Nonhuman Primates
Hemagglutinin (HA) on the surface of influenza viruses binds to sialic acids, mainly N-acetylneuraminic acid (Neu5Ac) or N-glycolylneuraminic acid....
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Western Blot Analysis in Ewing Sarcoma
Western blot is an experimental method used to analyze protein expression. In Ewing sarcoma, as in many other diseases, Western blot provides...
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Lectin and Liquid Chromatography-Based Methods for Immunoglobulin (G) Glycosylation Analysis
Immunoglobulin (Ig) glycosylation has been shown to dramatically affect its structure and effector functions. Ig glycosylation changes have been...
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CLEC19A overexpression inhibits tumor cell proliferation/migration and promotes apoptosis concomitant suppression of PI3K/AKT/NF-κB signaling pathway in glioblastoma multiforme
BackgroundGBM is the most frequent malignant primary brain tumor in humans. The CLEC19A is a member of the C-type lectin family, which has a high...
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Identification of ADP/ATP Translocase 1 as a Novel Glycoprotein and Its Association with Parkinson’s Disease
Protein glycosylation plays a crucial role in central nervous system, and abnormal glycosylation has major implications for human diseases. This...
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Comprehensive analysis identifies CLEC1B as a potential prognostic biomarker in hepatocellular carcinoma
BackgroundC-type lectin domain family 1 member B (CLEC1B, encoding the CLEC-2 protein), a member of the C-type lectin superfamily, is a type II...
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Fucosylated Proteins as Cancer Biomarkers
Fucosylation, a type of glycosylation associated with cancer and inflammation, involves the attachment of fucose residues to glycans. Fucosylation is...
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Intracellular immune sensing promotes inflammation via gasdermin D–driven release of a lectin alarmin
Inflammatory caspase sensing of cytosolic lipopolysaccharide (LPS) triggers pyroptosis and the concurrent release of damage-associated molecular...
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Interference in melanoma CD248 function reduces vascular mimicry and metastasis
BackgroundTumor vascular mimicry is an emerging issue that affects patient survival while having no treatment at the current moment. Despite several...
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ZG16 promotes T-cell mediated immunity through direct binding to PD-L1 in colon cancer
Immunotherapy using programmed cell death 1 (PD1) inhibitors has shown great efficacy in colorectal cancer patients harboring...
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Tumor-suppressive miR-4732-3p is sorted into fucosylated exosome by hnRNPK to avoid the inhibition of lung cancer progression
BackgroundAberrant fucosylation observed in cancer cells contributes to an augmented release of fucosylated exosomes into the bloodstream, where...
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Selective targeting of lectins and their macropinocytosis in urothelial tumours: translation from in vitro to ex vivo
Urinary bladder cancer can be treated by intravesical application of therapeutic agents, but the specific targeting of cancer urothelial cells and...
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Siglec-E Ligand Downregulation on Hippocampus Neurons Induced Inflammation in Sevoflurane-Associated Perioperative Neurocognitive Disorders in Aged Mice
Activated microglia-induced inflammation in the hippocampus plays an important role in perioperative neurocognitive disorders. Previous studies have...
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Diagnostic value of glycoprotein band patterns of three serologic enzyme-linked immunoelectrotransfer blot assays for neurocysticercosis
The enzyme-linked immunoelectrotransfer blot (EITB) assay to detect antibodies in serum is a complementary tool for the diagnosis of...
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An N-glycoproteomic site-map** analysis reveals glycoprotein alterations in esophageal squamous cell carcinoma
BackgroundAberrant glycosylation has been recognized as a hallmark of cancer and N-glycosylation is one of the main types of glycosylation in...
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Immunogens in Balamuthia mandrillaris: a proteomic exploration
Balamuthia mandrillaris is the causative agent of granulomatous amoebic encephalitis, a rare and often fatal infection affecting the central nervous...
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CD13 facilitates immune cell migration and aggravates acute injury but promotes chronic post-stroke recovery
IntroductionAcute stroke leads to the activation of myeloid cells. These cells express adhesion molecules and transmigrate to the brain, thereby...
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The podoplanin-CLEC-2 interaction promotes platelet-mediated melanoma pulmonary metastasis
BackgroundPodoplanin (PDPN) expressed on tumour cells interacts with platelet C-type lectin-like receptor 2 (CLEC-2). This study aimed to investigate...
