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The estimation of acute oral toxicity (LD50) of G-series organophosphorus-based chemical warfare agents using quantitative and qualitative toxicology in silico methods
The idea of this study was the estimation of the theoretical acute toxicity (t-LD 50 , rat, oral dose) of organophosphorus-based chemical warfare...
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Improved up-and-down procedure for acute toxicity measurement with reliable LD50 verified by typical toxic alkaloids and modified Karber method
BackgroundUp-and-down procedure (UDP) was recommended to replace traditional acute toxicity methods. However, it was limited due to the long...
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Application of toxicology in silico methods for prediction of acute toxicity (LD50) for Novichoks
Novichoks represent the fourth generation of chemical warfare agents with paralytic and convulsive effects, produced clandestinely during the Cold...
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The prediction of acute toxicity (LD50) for organophosphorus-based chemical warfare agents (V-series) using toxicology in silico methods
Nerve agents are organophosphate chemical warfare agents that exert their toxic effects by irreversibly inhibiting acetylcholinesterase, affecting...
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Estimation of LD50 and effect of sodium azide on germination and seedling parameters of different cultivars of Cajanus cajan (L.) Millspaugh
ObjectiveThe present investigation was undertaken for determination of LD 50 and studying response exhibited by selected cultivars of pigeon pea for...
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Low-dose cone-beam CT (LD-CBCT) reconstruction for image-guided radiation therapy (IGRT) by three-dimensional dual-dictionary learning
BackgroundTo develop a low-dose cone beam CT (LD-CBCT) reconstruction method named simultaneous algebraic reconstruction technique and...
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Extremely sparse models of linkage disequilibrium in ancestrally diverse association studies
Linkage disequilibrium (LD) is the correlation among nearby genetic variants. In genetic association studies, LD is often modeled using large...
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Involvement of the vagus nerve and hepatic gene expression in serum adiponectin concentrations in mice
Several humoral factors, such as adiponectin and urate, have been suggested to affect metabolic syndromes. Previously, we reported a reduction in...
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The value of CT shape quantification in predicting pathological classification of lung adenocarcinoma
ObjectiveTo evaluate whether quantification of lung GGN shape is useful in predicting pathological categorization of lung adenocarcinoma and guiding...
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Metabolic reprogramming and lipid droplets are involved in Zika virus replication in neural cells
Zika virus (ZIKV) infection is a global public health concern linked to adult neurological disorders and congenital diseases in newborns. Host lipid...
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Therapeutical strategies in cavitary legionnaires’ disease, two cases from the field and a systematic review
BackgroundLegionnaires’ Disease (LD) rarely evolves into pulmonary abscesses. The current systematic review has been designed to explore...
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A low dose of naloxone mitigates autoimmune hepatitis by regulating TLR4/NF-κB and Nrf2/HO-1 signaling pathways
Naloxone is a non-selective opiate receptor antagonist that is mainly used in the management of acute opioid overdose or intoxication. Previously,...
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Placental extract suppresses lipid droplet accumulation by autophagy during the differentiation of adipose-derived mesenchymal stromal/stem cells into mature adipocytes
ObjectivePlacental extract, which contains various bioactive compounds, has been used as traditional medicine. Many studies have demonstrated...
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Beneficial Effect of Fingolimod in a Lafora Disease Mouse Model by Preventing Reactive Astrogliosis-Derived Neuroinflammation and Brain Infiltration of T-lymphocytes
Lafora disease (LD; OMIM#254780) is a rare, devastating, and fatal form of progressive myoclonus epilepsy that affects young adolescents and has no...
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Map** the neuroanatomical abnormalities in a phenotype of male compulsive rats
Compulsivity is considered a transdiagnostic dimension in obsessive–compulsive and related disorders, characterized by heterogeneous cognitive and...
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Metabolic PET/CT analysis of aggressive Non-Hodgkin lymphoma prior to Axicabtagene Ciloleucel CAR-T infusion: predictors of progressive disease, survival, and toxicity
PET/CT is used to evaluate relapsed/refractory non-Hodgkin lymphoma (NHL) prior to chimeric antigen receptor T-cell (CAR-T) infusion at two time...
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BDNF Val66Met Polymorphism: Suggested Genetic Involvement in Some Children with Learning Disorder
Brain-derived neurotrophic factor (BDNF) plays an essential role in neuronal survival, especially in areas responsible for memory and learning. The...
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Reducing and controlling metabolic active tumor volume prior to CAR T-cell infusion can improve survival outcomes in patients with large B-cell lymphoma
Bridging therapy before CD19-directed chimeric antigen receptor (CAR) T-cell infusion is frequently applied in patients with relapsed or refractory...
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PSCA-CAR T cell therapy in metastatic castration-resistant prostate cancer: a phase 1 trial
Despite recent therapeutic advances, metastatic castration-resistant prostate cancer (mCRPC) remains lethal. Chimeric antigen receptor (CAR) T cell...
