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Roles of KCNA2 in Neurological Diseases: from Physiology to Pathology
Potassium voltage-gated channel subfamily a member 2 (Kv1.2, encoded by KCNA2 ) is highly expressed in the central and peripheral nervous systems....
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Hypergravity Increases the Number of Gene Transcripts of Mechanically Gated and Mechanosensitive Ion Channels in Rat Ventricular Cardiomyocytes
Since hypergravity changes the morphological and physiological properties of the heart, it was assumed that the expression of ion channels that...
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Acute axon damage and demyelination are mitigated by 4-aminopyridine (4-AP) therapy after experimental traumatic brain injury
Damage to long axons in white matter tracts is a major pathology in closed head traumatic brain injury (TBI). Acute TBI treatments are needed that...
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TET1 Overexpression Mitigates Neuropathic Pain Through Rescuing the Expression of μ-Opioid Receptor and Kv1.2 in the Primary Sensory Neurons
Peripheral nerve injury downregulates the expression of the μ-opioid receptor (MOR) and voltage-gated potassium channel subunit Kv1.2 by increasing...
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Effect of Pharmacological Inhibition of Fat-Mass and Obesity-Associated Protein on Nerve Trauma-Induced Pain Hypersensitivities
Genetic knockout or knockdown of fat-mass and obesity-associated protein (FTO), a demethylase that participates in RNA N 6 -methyladenosine...
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Projection-Specific Heterogeneity of the Axon Initial Segment of Pyramidal Neurons in the Prelimbic Cortex
The axon initial segment (AIS) is a highly specialized axonal compartment where the action potential is initiated. The heterogeneity of AISs has been...
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Gene therapy for chronic pain: emerging opportunities in target-rich peripheral nociceptors
With swee** advances in precision delivery systems and manipulation of the genomes and transcriptomes of various cell types, medical biotechnology...
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The Node of Ranvier as an Interface for Axo-Glial Interactions: Perturbation of Axo-Glial Interactions in Various Neurological Disorders
The action potential conduction along the axon is highly dependent on the healthy interactions between the axon and myelin-producing glial cells....
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Cerebellar Biochemistry/Pharmacology
Cerebellar Purkinje cells (PCs) are localized in the cerebellar cortex and are characterized by highly developed dendrites, which receive different...
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TET1 Participates in Complete Freund’s Adjuvant-induced Trigeminal Inflammatory Pain by Regulating Kv7.2 in a Mouse Model
Trigeminal inflammatory pain is one of the most severe pain-related disorders in humans; however, the underlying mechanisms remain largely unknown....
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Systemic Inflammation Leads to Changes in the Intracellular Localization of KLK6 in Oligodendrocytes in Spinal Cord White Matter
Axonal injury and demyelination occur in demyelinating diseases, such as multiple sclerosis, and the detachment of myelin from axons precedes its...
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Effects of Kv1.3 knockout on pyramidal neuron excitability and synaptic plasticity in piriform cortex of mice
Kv1.3 belongs to the voltage-gated potassium (Kv) channel family, which is widely expressed in the central nervous system and associated with a...
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Glycans and Carbohydrate-Binding/Transforming Proteins in Axon Physiology
The mature nervous system relies on the polarized morphology of neurons for a directed flow of information. These highly polarized cells use their...
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Ion Channel Genes and Ataxia
In this review we will discuss ataxic disorders attributed to mutations in ion channel genes. Such disorders seem to preferentially effect cerebellar...
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Endogenous ion channels expressed in human embryonic kidney (HEK-293) cells
Mammalian expression systems, particularly the human embryonic kidney (HEK-293) cells, combined with electrophysiological studies, have greatly...
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Restoring a Loss of Mossy Fiber Plasticity in a Model of Fragile X Syndrome
Fragile X Syndrome is a monogenic disorder that reflects a loss of Fragile X Mental Retardation Protein (FMRP) that is needed to regulate translation...
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Channelopathies in fragile X syndrome
Fragile X syndrome (FXS) is the most common inherited form of intellectual disability and the leading monogenic cause of autism. The condition stems...
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Voltage-dependent gating in K channels: experimental results and quantitative models
Voltage-dependent K channels open and close in response to voltage changes across the cell membrane. This voltage dependence was postulated to depend...
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Genomic Structure of Two Kv1.3 Channel Blockers from Scorpion Mesobuthus eupeus and Sea Anemone Stichodactyla haddoni and Construction of their Chimeric Peptide as a Novel Blocker
Different toxins acting on Kv1.3 channel have been isolated from animal venom. MeuKTX toxin from Mesobuthus eupeus phillipsi scorpion and shtx-k...
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Small G—protein RhoA is a potential inhibitor of cardiac fast sodium current
Small G-proteins of Rho family modulate the activity of several classes of ion channels, including K + channels Kv1.2, Kir2.1, and ERG; Ca 2+ channels;...
