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Expressional variations of Kaiso: an association with pathological characteristics and field cancerization of OSCC
BackgroundA group of genetically altered cells that have not transformed into a clinical or histologically identifiable state of malignancy but...
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Comprehensive analysis of the REST transcription factor regulatory networks in IDH mutant and IDH wild-type glioma cell lines and tumors
The RE1-silencing transcription factor (REST) acts either as a repressor or activator of transcription depending on the genomic and cellular context....
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Co-immunoprecipitation of Protein Complexes from Different Subcellular Compartments in Vasculogenic Mimicry Studies
Aberrant extravascular expression of VE-cadherinVE-cadherin has been observed in metastasisMetastasis associated with vasculogenic mimicry...
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Gastric Epithelial Barrier Disruption, Inflammation and Oncogenic Signal Transduction by Helicobacter pylori
Helicobacter pylori exemplifies one of the most favourable bacterial pathogens worldwide. The bacterium colonizes the gastric mucosa in about half of...
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Kaiso is highly expressed in TNBC tissues of women of African ancestry compared to Caucasian women
PurposeTriple-negative breast cancer (TNBC) is most prevalent in young women of African ancestry (WAA) compared to women of other ethnicities. Recent...
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A cross-cohort analysis of autosomal DNA methylation sex differences in the term placenta
BackgroundHuman placental DNA methylation (DNAme) data is a valuable resource for studying sex differences during gestation, as DNAme profiles after...
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The emerging roles of circular RNAs in vessel co-option and vasculogenic mimicry: clinical insights for anti-angiogenic therapy in cancers
Unexpected resistance to anti-angiogenic treatment prompted the investigation of non-angiogenic tumor processes. Vessel co-option (VC) and...
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Identification of ZBTB4 as an immunological biomarker that can inhibit the proliferation and invasion of pancreatic cancer
BackgroundZinc finger and BTB domain-containing protein 4 (ZBTB4) belongs to the zinc finger protein family, which has a role in regulating...
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SPATA33 affects the formation of cell adhesion complex by interacting with CTNNA3 in TM4 cells
Communication between Sertoli cell is essential during spermatogenesis and testicular development in mice, and the dynamic balance of this...
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Epigenetic Control and Cerebellar Neurodevelopmental Disorders
Epigenetic mechanisms regulate cellular identity and organ morphology via instructing the gene expression program of specific cell types. Such...
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Role of Epigenetics in Colorectal Cancer
In 2018 alone, colorectal cancer (CRC) accounted for 10.2% among all cancer cases. It is known to be a consequence of accumulated alterations in the...
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Circular RNA EIF4G3 suppresses gastric cancer progression through inhibition of β-catenin by promoting δ-catenin ubiquitin degradation and upregulating SIK1
BackgroundIncreasing studies suggest that circular RNAs (circRNAs) are critical regulators of cancer development and progression. However, the...
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Inhibition of CD146 lessens uveal melanoma progression through reducing angiogenesis and vasculogenic mimicry
PurposeAnti-angiogenesis drug therapy is ineffective in treating uveal melanoma since it only targets angiogenesis leaving vasculogenic mimicry...
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Analysis of Il36a induction by C/EBPβ via a half-CRE•C/EBP element in murine macrophages in dependence of its CpG methylation level
Interleukin-36α is a novel member of the IL-1 cytokine family that is highly expressed in epithelial tissues and several myeloid-derived cell types...
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Cancer-associated fibroblasts and resistance to anticancer therapies: status, mechanisms, and countermeasures
Cancer-associated fibroblasts (CAFs) are critical components of the tumor microenvironment (TME) with diverse functions such as extracellular matrix...
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lncRNA APOC1P1-3 promoting anoikis-resistance of breast cancer cells
BackgroundAnoikis resistance plays a critical role in the tumor metastasis by allowing survival of cancer cells in the systemic circulation. We...
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Generating specificity in genome regulation through transcription factor sensitivity to chromatin
Cell type-specific gene expression relies on transcription factors (TFs) binding DNA sequence motifs embedded in chromatin. Understanding how motifs...
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Advances in culture, expansion and mechanistic studies of corneal endothelial cells: a systematic review
Human corneal endothelial cells are notorious for their restricted proliferative ability in vivo and in vitro. Hence, injury or dysfunction of these...
