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KCNQ Channels in the Mesolimbic Reward Circuit Regulate Nociception in Chronic Pain in Mice
Mesocorticolimbic dopaminergic (DA) neurons have been implicated in regulating nociception in chronic pain, yet the mechanisms are barely understood....
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Acute Treatment with the M-Channel (Kv7, KCNQ) Opener Retigabine Reduces the Long-Term Effects of Repetitive Blast Traumatic Brain Injuries
We investigated whether pharmacological increase of “M-type” (KCNQ, K v 7) K + channel currents by the M-channel opener, retigabine (RTG), acutely...
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Pharmacological Activation of Neuronal Voltage-Gated Kv7/KCNQ/M-Channels for Potential Therapy of Epilepsy and Pain
Native M-current is a low-threshold, slowly activating potassium current that exerts an inhibitory control over neuronal excitability. The M-channel...
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Functional characterization and in vitro pharmacological rescue of KCNQ2 pore mutations associated with epileptic encephalopathy
Mutations in the KCNQ2 gene encoding K V 7.2 subunit that mediates neuronal M-current cause a severe form of developmental and epileptic encephalopathy...
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The impact of hyperpolarization-activated cyclic nucleotide-gated (HCN) and voltage-gated potassium KCNQ/Kv7 channels on primary microglia function
BackgroundMicroglia are essential to maintain cell homeostasis in the healthy brain and are activated after brain injury. Upon activation, microglia...
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Triclosan is a KCNQ3 potassium channel activator
KCNQ channels participate in the physiology of several cell types. In neurons of the central nervous system, the primary subunits are KCNQ2, 3, and...
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Regulation of Neurotransmitter Release by K+ Channels
K+ channels play potent roles in the process of neurotransmitter release by influencing the action potential waveform and modulating neuronal...
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Function of KCNQ2 channels at nodes of Ranvier of lumbar spinal ventral nerves of rats
Previous immunohistochemical studies have shown the expression of KCNQ2 channels at nodes of Ranvier (NRs) of myelinated nerves. However, functions...
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Epileptic channelopathies caused by neuronal Kv7 (KCNQ) channel dysfunction
Seizures are the most common neurological manifestation in the newborn period, with an estimated incidence of 1.8–3.5 per 1000 live births. Prolonged...
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Novel KCNQ4 variants in different functional domains confer genotype- and mechanism-based therapeutics in patients with nonsyndromic hearing loss
Loss-of-function variant in the gene encoding the KCNQ4 potassium channel causes autosomal dominant nonsyndromic hearing loss (DFNA2), and no...
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Characterization and functional roles of KCNQ-encoded voltage-gated potassium (Kv7) channels in human corpus cavernosum smooth muscle
The group of KCNQ-encoded voltage-gated potassium (Kv7) channels includes five family members (Kv7.1–7.5). We examined the molecular expression and...
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KCNE Regulation of KCNQ Channels
Voltage-gated potassium (Kv) channels are perhaps best known for their roles in the action potentials of excitable cells, but they also fulfill a...
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Overlooked KCNQ4 variants augment the risk of hearing loss
Pathogenic variants of KCNQ4 cause symmetrical, late-onset, progressive, high-frequency-affected hearing loss, which eventually involves all...
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Involvement of Ca2+ in Signaling Mechanisms Mediating Muscarinic Inhibition of M Currents in Sympathetic Neurons
Acetylcholine can excite neurons by suppressing M-type (KCNQ) potassium channels. This effect is mediated by M 1 muscarinic receptors coupled to the G q ...
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Mechanisms of opioid-induced respiratory depression
Opioid-induced respiratory depression (OIRD), the primary cause of opioid-induced death, is the neural depression of respiratory drive which,...
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Kv7 Channels and Excitability Disorders
Kv7.1-Kv7.5 (KCNQ1–5) K+ channels are voltage-gated K+ channels with major roles in neurons, muscle cells and epithelia where they underlie...
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The Role of Ion Channel in Epilepsy Including SUDEP Cases
Epilepsy is a central nervous system disorder characterized by recurrent seizures. Identification of seizures with excessive electrical activity can...
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The Role of Ion Channel in Epilepsy Including SUDEP Cases
Epilepsy is a central nervous system disorder characterized by recurrent seizures. Identification of seizures with excessive electrical activity can...
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K Channel Openers as New Antiarrhythmic Agents
Cardiac cation channels are membrane proteins that provide controlled ion passage through cellular membranes to allow electrical control of the...
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Genes Encoding Ion Channels in Neurotherapeutics: Opportunities and Challenges
Neurotherapy measures and regulates the electrical signals produced by the neurons of the brain. The variation of the electrical activity in the...