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Oxidative stress responses as a marker of toxicity in mice exposed to polluted groundwater from an automobile junk market in South-Western Nigeria
The global trade in used vehicles and their components generates huge financial benefits but leads to detrimental environmental consequences...
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Dynamic alternative DNA structures in biology and disease
Repetitive elements in the human genome, once considered ‘junk DNA’, are now known to adopt more than a dozen alternative (that is, non-B) DNA...
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Comparative analysis of the DNA methylation landscape in CD4, CD8, and B memory lineages
BackgroundThere is considerable evidence that epigenetic mechanisms and DNA methylation are critical drivers of immune cell lineage differentiation...
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DNA as Tool for Revealing Truth in Civil as Well as Criminal Cases
Law and science have joined hands to meet the ends of justice, have also been in uneasy alliances with each other. The fast development in the area...
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Transposable Elements: Emerging Therapeutic Targets in Neurodegenerative Diseases
Neurodegenerative diseases, such as Alzheimer’s disease (AD), Parkinson’s disease (PD), and amyotrophic lateral sclerosis (ALS), are characterized by...
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Towards targeting transposable elements for cancer therapy
Transposable elements (TEs) represent almost half of the human genome. Historically deemed ‘junk DNA’, recent technological advancements have...
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The Role of Satellite DNA in Causing Structural Rearrangements in Human Karyotype
AbstractSatellite DNA, whose monomers form long arrays of tandem repeat ranging from hundreds or thousands of copies to several million base pairs,...
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Introduction to Forensic DNA Analysis
DNA fingerprinting analysis has been proved to be a useful tool for crime scene investigation to aid the criminal justice system. With wide media...
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Pseudogenes: Four Decades of Discovery
A pseudogene is defined as a genomic DNA sequence that looks like a mutated or truncated version of a known functional gene. Nearly four decades...
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Pseudogenes as Biomarkers and Therapeutic Targets in Human Cancers
Pseudogenes are commonly labeled as “junk DNA” given their perceived nonfunctional status. However, the advent of large-scale genomics projects...
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Programmed Evolution by miRNA Memory
Diseases are deeply implicated in the aberrant expression of microRNA (miRNA) genes. The RNA Wave 2000 dogma consists of four criteria, as first...
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The Viruses Within – How Human Are We?
The sequencing of the human genome revealed that 5–8%of our DNA is not inherently human, but instead is viral DNA, primarily retroviral DNA. These...
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Long non-coding RNAs: novel regulators of cellular physiology and function
Long non-coding RNAs were once considered as “junk” RNA produced by aberrant DNA transcription. They are now understood to play central roles in...
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CRISPR/Cas Technologies Applied to Pseudogenes
Pseudogenes have been considered as nonfunctional copies of their parental genes for a long time. Indeed, they have been often defined “junk DNA” or...
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Non-coding RNAs as liquid biopsy biomarkers in cancer
Although non-coding RNAs have long been considered as non-functional “junk” RNAs, accumulating evidence in the past decade indicates that they play a...
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Pseudogenes: A Novel Source of Trans-Acting Antisense RNAs
Several recent studies support a functional role for pseudogenes, a copy of a parent gene that has lost protein-coding potential, which was for a...