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A clinical review of HIV integrase strand transfer inhibitors (INSTIs) for the prevention and treatment of HIV-1 infection
Integrase strand transfer inhibitors (INSTIs) have improved the treatment of human immunodeficiency virus (HIV). There are currently four approved...
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Integrase Inhibitors are Associated with Neuropsychiatric Symptoms in Women with HIV
ObjectiveWomen with HIV(WWH) are more likely to discontinue/change antiretroviral therapy(ART) due to side effects including neuropsychiatric...
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Potential drug–drug interactions in the era of integrase strand transfer inhibitors: a cross-sectional single-center study in Japan
BackgroundPotential drug–drug interactions (PDDIs) commonly occur because of aging and comorbidities in people living with human immunodeficiency...
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Stable expression of large transgenes via the knock-in of an integrase-deficient lentivirus
The targeted insertion and stable expression of a large genetic payload in primary human cells demands methods that are robust, efficient and easy to...
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LEDGINs, Inhibitors of the Interaction Between HIV-1 Integrase and LEDGF/p75, Are Potent Antivirals with a Potential to Cure HIV Infection
A permanent cure remains the greatest challenge in the field of HIV research. In order to reach this goal, a profound understanding of the molecular...
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Study on suitable analysis method for HIV-1 non-catalytic integrase inhibitor
BackgroundIntegrase (IN) is an essential protein for HIV replication that catalyzes insertion of the reverse-transcribed viral genome into the host...
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Carboxylated chalcones and related flavonoids as inhibitors of xanthine oxidase
Carboxylated chalcones and other related flavonoids were synthesized and evaluated as inhibitors of xanthine oxidase, which is a known target for...
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Influence of the amino-terminal sequence on the structure and function of HIV integrase
BackgroundAntiretroviral therapy (ART) can mitigate the morbidity and mortality caused by the human immunodeficiency virus (HIV). Successful...
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HTLV-1 reverse transcriptase homology model provides structural basis for sensitivity to existing nucleoside/nucleotide reverse transcriptase inhibitors
The human T-lymphotropic virus type 1 (HTLV-1) infects millions of people globally and is endemic to various resource-limited regions. Infections...
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Suppression of HIV-1 Integration by Targeting HIV-1 Integrase for Degradation with A Chimeric Ubiquitin Ligase
Human immunodeficiency virus (HIV) attacks human immune system and causes life-threatening acquired immune deficiency syndrome (AIDS). Treatment with...
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HIV-1 integrase binding to genomic RNA 5′-UTR induces local structural changes in vitro and in virio
BackgroundDuring HIV-1 maturation, Gag and Gag-Pol polyproteins are proteolytically cleaved and the capsid protein polymerizes to form the honeycomb...
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In silico approaches for study the therapeutic potential of Cannabis sativa (Bhang) against HIV
Human Immunodeficiency Virus (HIV) is one of the world's most significant public health issues. HIV become severe in the COVID pandemic. Scientists...
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Recent Updates on In Silico Screening of Natural Products as Potential Inhibitors of Enzymes of Biomedical and Pharmaceutical Importance
Natural products from medicinal plants have been increasingly used in modern medicine due to their safety, efficacy, and lesser toxicity. World over,...
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The Role of Immune Checkpoint Inhibitors in the Treatment of Less Common Head and Neck Cancers
The role of immune checkpoint inhibitors in less common head and neck cancers, including non-squamous cell carcinoma, is less known. This chapter...
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DNA sequence-specific ligands. XX. Synthesis, spectral properties, virological and biochemical studies of fluorescent dimeric trisbenzimidazoles DB3P(n)
A new series of AT-specific minor groove DNA ligands (DB 3 P( n ); n = 1,2,3,4) was synthesized and their spectral, biological and virological properties...
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Withania somnifera extracts induced attenuation of HIV-1: a mechanistic approach to restrict viral infection
BackgroundSeveral anti-retroviral drugs are available against Human immunodeficiency virus type-1, but have multiple adverse side effects. Hence,...
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Synergistic Herb-Drug Interactions Against Viral Diseases
Emerging or reemerging viruses are of serious concern as they are associated with higher degree of mortality and deleterious impact on human life....
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Re-evaluating the relationship between youth with HIV and BMI in an age of increasing rates of overweight and obese youth
BackgroundNewer antiretrivirals (ART) have shifted the metabolic experiences of people with HIV (PWH) from those of wasting syndrome to increases in...
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Histone deacetylase 1 interacts with HIV-1 Integrase and modulates viral replication
BackgroundHIV-1 hijacks the cellular machinery for its own replication through protein-protein interactions between viral and host cell factors. One...
