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Generation of Protease Inhibitory Antibodies by Functional In Vivo Selection
Targeting dysregulated protease expression and/or abnormal substrate proteolysis, highly selective inhibition of pathogenic proteases by monoclonal...
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A high-throughput screening assay to identify inhibitory antibodies targeting alphavirus release
BackgroundSeveral studies have demonstrated neutralizing antibodies to be highly effective against alphavirus infection in animal models, both...
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The malaria blood stage antigen PfCyRPA formulated with the TLR-4 agonist adjuvant GLA-SE elicits parasite growth inhibitory antibodies in experimental animals
BackgroundPlasmodium falciparum cysteine-rich protective antigen ( Pf CyRPA) is an invasion complex protein essential for erythrocyte invasion. In...
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Monoclonal Antibodies in Solid Organ Transplantation
In an attempt to target solid organ transplant immunosuppression, monoclonal antibodies directed against key steps in specific immunologic pathways...
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Fcγ receptors and immunomodulatory antibodies in cancer
The discovery of both cytotoxic T lymphocyte-associated antigen 4 (CTLA4) and programmed cell death protein 1 (PD1) as negative regulators of...
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Cancer therapy with antibodies
The greatest challenge in cancer therapy is to eradicate cancer cells with minimal damage to normal cells. Targeted therapy has been developed to...
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Titers of antibodies against ancestral SARS-CoV-2 correlate with levels of neutralizing antibodies to multiple variants
Diagnostic assays currently used to monitor the efficacy of COVID-19 vaccines measure levels of antibodies to the receptor-binding domain of...
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Bispecific Antibodies in Targeted Cancer Immunotherapy
Cancer immunotherapy focused on monoclonal antibodies (mAbs) has emerged as a powerful tool in the armamentarium against tumors. In this regard,...
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Antibodies toward Na+,HCO3–-cotransporter NBCn1/SLC4A7 block net acid extrusion and cause pH-dependent growth inhibition and apoptosis in breast cancer
BackgroundNa + ,HCO 3 – -cotransporter NBCn1/Slc4a7 accelerates murine breast carcinogenesis. Lack of specific pharmacological tools previously...
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Distribution Patterns of Subgroups of Inhibitory Neurons Divided by Calbindin 1
The inhibitory neurons in the brain play an essential role in neural network firing patterns by releasing γ-aminobutyric acid (GABA) as the...
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The present and future of bispecific antibodies for cancer therapy
Bispecific antibodies (bsAbs) enable novel mechanisms of action and/or therapeutic applications that cannot be achieved using conventional IgG-based...
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Comparative analyses of functional antibody-mediated inhibition with anti-circumsporozoite monoclonal antibodies against transgenic Plasmodium berghei
BackgroundAcquired functional inhibitory antibodies are one of several humoral immune mechanisms used to neutralize foreign pathogens. In vitro...
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Anti-TRAP/SSP2 monoclonal antibodies can inhibit sporozoite infection and may enhance protection of anti-CSP monoclonal antibodies
Vaccine-induced sterilizing protection from infection by Plasmodium parasites, the pathogens that cause malaria, will be essential in the fight...
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Gating of Social Behavior by Inhibitory Inputs from Hippocampal CA1 to Retrosplenial Agranular Cortex
The retrosplenial cortex has been implicated in processing sensory information and spatial learning, with abnormal neural activity reported in...
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Monoclonal Antibodies in Nanosystems as a Strategy for Cancer Treatment
Monoclonal antibodies (mAbs) are valuable therapeutic tools for targeted therapies to attack tumor cells but preserve healthy tissues, therefore...
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Oxidized galectin-1 in SLE fails to bind the inhibitory receptor VSTM1 and increases reactive oxygen species levels in neutrophils
Inhibitory immune receptors set thresholds for immune cell activation, and their deficiency predisposes a person to autoimmune responses. However,...
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Inhibitory control of sharp-wave ripple duration during learning in hippocampal recurrent networks
Recurrent excitatory connections in hippocampal regions CA3 and CA2 are thought to play a key role in the generation of sharp-wave ripples (SWRs),...
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B Cell Immunity: BCRs, Antibodies and Their Effector Functions
In this chapter, we will explain that B cells respond to antigen stimulation of their BCR with the production of antibodies. This is a key feature of...
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Microglia enhance post-anesthesia neuronal activity by shielding inhibitory synapses
Microglia are resident immune cells of the central nervous system and play key roles in brain homeostasis. During anesthesia, microglia increase...
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Novel multivalent S100A8 inhibitory peptides attenuate tumor progression and metastasis by inhibiting the TLR4-dependent pathway
The tumor-elicited inflammation is closely related to tumor microenvironment during tumor progression. S100A8 , an endogenous ligand of Toll-like...
