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Local origin of excitatory–inhibitory tuning equivalence in a cortical network
The interplay between excitation and inhibition determines the fidelity of cortical representations. The receptive fields of excitatory neurons are...
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Independent inhibitory control mechanisms for aggressive motivation and action
Social behaviors often consist of a motivational phase followed by action. Here we show that neurons in the ventromedial hypothalamus ventrolateral...
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Reverse Inhibitory Connections via GABAB-Receptors Synchronize Interictal Discharges in the Cortex
Current experimental evidence shows that interictal discharges consist of a short spike and a slow wave, which is regarded as long-lasting...
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Expression analysis of inhibitory B7 family members in Alzheimer’s disease
Alzheimer’s disease (AD) is a global health problem due to its complexity, which frequently makes the development of treatment methods extremely...
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Synthesis and antiviral property of polysulfate-grafted maleimide-based enediynes
Human coronaviruses, including the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), pose a serious threat to human life and the global...
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Imbalances of Inhibitory and Excitatory Systems in Autism Spectrum Disorders
Autism Spectrum Disorder (ASD) encompasses a wide range of phenotypically related conditions, with individuals on the spectrum exhibiting varied...
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Synchronization and oscillation behaviors of excitatory and inhibitory populations with spike-timing-dependent plasticity
The effect of synaptic plasticity on the synchronization mechanism of the cerebral cortex has been a hot research topic over the past two decades....
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Identification of CEACAM5 as a stemness-related inhibitory immune checkpoint in pancreatic cancer
BackgroundImmunotherapy has emerged as a new cancer treatment modality. However, tumour heterogeneity can diminish checkpoint blockade response and...
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Anti-hyperuricemic potential of caryophyllene from Syzygium aromaticum essential oil: SiO2-AgNO3-based column chromatography purification, antioxidant, and xanthine oxidase inhibitory activities
Xanthine oxidase is an enzyme that plays an essential role in the biosynthesis of uric acid. Inhibiting this enzyme can diminish the production of...
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Vitamin D Presented In Vitro Immunomodulatory Property on T Lymphocyte-Related Cytokines in Systemic Lupus Erythematosus
Inflammatory T lymphocyte cytokines contribute to tissue damage in SLE patients. Vitamin D (Vit D) has a well-established immunomodulatory action,...
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Whole-Brain Direct Inputs to and Axonal Projections from Excitatory and Inhibitory Neurons in the Mouse Primary Auditory Area
Neurons in the primary auditory area (AUDp) innervate multiple brain regions with long-range projections while receiving informative inputs for...
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Cytokines inhibitory mechanism of Prunus domestica L. (Plum) peptides as potential immunomodulators against systemic lupus erythematosus: an in-silico screening
Natural bioactive peptides exhibit various chemical and structural properties to enhance the immune response against multiple inflammatory and...
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Effects of sex and age on presumed inhibitory interactions in 6 areas of the human cerebral cortex as revealed by the fMRI Human Connectome Project
Cortical inhibition is theorized to reflect an underlying property of human brain function, sharpening tuning and sha** connectivity. Although age...
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Antiallodynic effects of KDS2010, a novel MAO-B inhibitor, via ROS-GABA inhibitory transmission in a paclitaxel-induced tactile hypersensitivity model
Monoamine oxidase (MAO) inhibitors have been investigated for the treatment of neuropathic pain. Here, we assessed the antiallodynic effects of a...
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Diurnal rhythm regulates the frequency of carbachol-induced beta oscillation via inhibitory neural system in rat hippocampus
Animals have a diurnal rhythm with a cycle of approximately 1 day modulated by light information. This rhythm modulates memory performance....
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The Anti-inflammation Property of Olfactory Ensheathing Cells in Neural Regeneration After Spinal Cord Injury
Neural regeneration has troubled investigators worldwide in the past decades. Currently, cell transplantation emerged as a breakthrough targeted...
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Antimycobacterial, antibiofilm and efflux pump inhibitory activity of extracts from selected Combretum species used in traditional medicine in Zimbabwe
Non-tuberculous mycobacteria infect mostly immunocompromised people. NTM infections incidence and prevalence increase has led to a public health...
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Synthesis of adamantane-monoterpene conjugates with 1,3,4-thiadiazol-2(3H)-imine linker and evaluation of their inhibitory activity against TDP1
Tyrosyl-DNA phosphodiesterase 1 (TDP1) is a DNA repair enzyme that can reduce the efficacy of some anticancer drugs targeting topoisomerase 1 (TOP1)...
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Investigations of AGEs’ inhibitory and nephroprotective potential of ursolic acid towards reduction of diabetic complications
In diabetes, interactions between AGEs (advanced glycation end products) and RAGEs (receptors of AGEs) are responsible for chronic complications and...
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Anti-rheumatic property and physiological safety of KMU-11342 in in vitro and in vivo models
Rheumatoid arthritis (RA) is a chronic, systemic inflammatory disorder characterized by joint destruction due to synovial hypertrophy and the...
