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Technical Considerations for In Vivo Electrophysiology
In Chapter 23 , we discussed general considerations regarding the design of in vivo recording...
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The world’s first digital cell twin in cancer electrophysiology: a digital revolution in cancer research?
BackgroundThe introduction of functional in-silico models, in addition to in-vivo tumor models, opens up new and unlimited possibilities in cancer...
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Recent advances and current limitations of available technology to optically manipulate and observe cardiac electrophysiology
Optogenetics, utilising light-reactive proteins to manipulate tissue activity, are a relatively novel approach in the field of cardiac...
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In Vivo Calcium Imaging of Peripheral Ganglia
Calcium dynamics are a proxy for neuronal firing, yet studying those dynamics requires dissociation protocols that lead to cellular milieu that may...
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Estimating the Ca2+ Block of NMDA Receptors with Single-Channel Electrophysiology
In vertebrate central neurons, NMDA receptors are glutamate- and glycine-gated ion channels that allow the passage of Na+ and Ca2+ ions into the cell...
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Noninvasive Electrophysiology
Since the original development of noninvasive electrophysiology its role has evolved. In this chapter, we outline the utilization of noninvasive...
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Electrophysiology and Single Cells
Information processing, storage, and retrieval in the central nervous system are largely dependent on the electrical activity of single neurons and...
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In Vivo Viral Gene Delivery to Manipulate Functional Properties of AMPA Receptors in Oligodendrocyte Lineage Cells
Delivery or deletion of genes of interest in the nervous system of animals in vivo is a complex and difficult task. While genetic manipulations can...
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In Vivo Electrophysiology for Reward Anticipation and Processing
One of the humans’ most adaptive functions is the brain’s ability to predict future outcomes, especially regarding the ability to secure rewards....
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Tracing in vivo the dorsal loop of the optic radiation: convergent perspectives from tractography and electrophysiology compared to a neuroanatomical ground truth
The temporo-parietal junction (TPJ) is a cortical area contributing to a multiplicity of visual, language-related, and cognitive functions. In line...
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Multimodal Nature of the Single-cell Primate Brain Atlas: Morphology, Transcriptome, Electrophysiology, and Connectivity
Primates exhibit complex brain structures that augment cognitive function. The neocortex fulfills high-cognitive functions through billions of...
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General Considerations for In Vivo Exploration of Synaptic Plasticity
Studying synaptic plasticity in a neuron’s in vivo milieu has unparalleled physiological relevance and translational values. Although in vivo and ex...
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Aη-α and Aη-β peptides impair LTP ex vivo within the low nanomolar range and impact neuronal activity in vivo
BackgroundAmyloid precursor protein (APP) processing is central to Alzheimer’s disease (AD) etiology. As early cognitive alterations in AD are...
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In Vivo Whole-Cell Recording in the Gerbil Cochlear Nucleus
This chapter describes how to use patch-clamp electrodes to perform blind in vivo whole-cell recording in the cochlear nucleus of anesthetized...
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In Vivo Whole-Cell Recording from the Mouse Brain
Measuring the membrane potential dynamics of neurons offers a comprehensive understanding of the molecular and cellular mechanisms that form their...
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In Vivo Non-linear Optical Microscopy as a Multidimensional Approach to Decipher Sensory Coding
Every type of sensation is mediated by diversified groups of sensory neurons, organized in multifaceted ensembles and complex temporal dynamics. It...
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Estimating the Ca2+ Permeability of NMDA Receptors with Whole-Cell Patch-Clamp Electrophysiology
In the mammalian central nervous system (CNS), fast excitatory transmission relies primarily on the ionic fluxes generated by ionotropic glutamate...
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In Vivo Manipulations to Correct for Behavioral Phenotypes in Cognitive Disorder Mouse Models
Identification of human mutations associated with syndromic and non-syndromic cognitive disorders (CD) has led to the creation of several hundreds...
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Retinal Assessment Using In Vivo Electroretinography and Optical Coherence Tomography in Rodent Models of Diabetes
Electroretinography and optical coherence tomography imaging allow for non-invasive quantitative assessment of the retina. These approaches have...
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Electrophysiology of Dendritic Spines: Information Processing, Dynamic Compartmentalization, and Synaptic Plasticity
For many years, synaptic transmission was considered as information transfer between presynaptic neuron and postsynaptic cell. At the synaptic level,...