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Immune correlates of protection following Rift Valley fever virus vaccination
Rift Valley fever virus (RVFV) is a hemorrhagic fever virus with the potential for significant economic and public health impact. Vaccination with an...
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Correlates of immune protection against human rotaviruses: natural infection and vaccination
Species A rotaviruses are the leading viral cause of acute gastroenteritis in children under 5 years of age worldwide. Despite progress in the...
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Oral administration of DNA alginate nanovaccine induced immune-protection against Helicobacter pylori in Balb/C mice
BackgroundHelicobacter pylori (H. Pylori), is an established causative factor for the development of gastric cancer and the induction of persistent...
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Strong immune responses and protection of PcrV and OprF-I mRNA vaccine candidates against Pseudomonas aeruginosa
Pseudomonas aeruginosa (PA) is a leading cause of hospital-acquired and ventilator-associated pneumonia. The multidrug-resistance (MDR) rate of PA is...
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IL-21 Enhances the Immune Protection Induced by the Vibrio vulnificus Hemolysin A Protein
We previously reported that the Vibrio vulnificus hemolysin A (VvhA) protein elicited good immune protection and could effectively control V....
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COVID-19 vaccine update: vaccine effectiveness, SARS-CoV-2 variants, boosters, adverse effects, and immune correlates of protection
Coronavirus Disease 2019 (COVID-19) has been the most severe public health challenge in this century. Two years after its emergence, the rapid...
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Early life microbial exposures shape the Crassostrea gigas immune system for lifelong and intergenerational disease protection
BackgroundThe interaction of organisms with their surrounding microbial communities influences many biological processes, a notable example of which...
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Correlates of protection against symptomatic SARS-CoV-2 in vaccinated children
The paucity of information on longevity of vaccine-induced immune responses and uncertainty of the correlates of protection hinder the development of...
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Immune Response
The specific reactivity induced by an antigenic stimulus in a host is known as an immune response. The immune system is developed in a host primarily...
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MCMV-based vaccine vectors expressing full-length viral proteins provide long-term humoral immune protection upon a single-shot vaccination
Global pandemics caused by influenza or coronaviruses cause severe disruptions to public health and lead to high morbidity and mortality. There...
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Cytomegalovirus immune evasion sets the functional avidity threshold for protection by CD8 T cells
Conflicting hallmarks are attributed to cytomegalovirus (CMV) infections. CMVs are viewed as being master tacticians in “immune evasion” by...
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Oral immunization of mice with recombinant Lactobacillus plantarum expressing a Trichinella spiralis galectin induces an immune protection against larval challenge
BackgroundTrichinella spiralis is an important foodborne parasite that presents a severe threat to food safety. The development of an anti- Trichinella...
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Potential biomarkers of immune protection in human leishmaniasis
Leishmaniasis is a vector-borne neglected tropical disease endemic in over 100 countries around the world. Available control measures are not always...
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Correlates of Protection from Tuberculosis
Multiple immunological mechanisms interact to protect against Mycobacterium tuberculosis (M.tb) infection and/or tuberculosis (TB) disease. However,...
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Echinococcosis Immune Response, Immunopathogenesis and Immune Evasion from the Human Host
Echinococcosis is a worldwide parasitic disease with great harm and complicated immune mechanisms. Immunoprophylaxis is an ideal way to prevent...
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Immune Response to Staphylococcus aureus
Although Staphylococcus aureus is not a high virulent pathogen in healthy persons, this bacterium often persists in various tissues and mucosa and...
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Immune escape of avian oncogenic Marek’s disease herpesvirus and antagonistic host immune responses
Marek’s disease virus (MDV) is a highly pathogenic and oncogenic alpha herpesvirus that causes Marek’s disease (MD), which is one of the most...
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Neutralizing antibody levels are highly predictive of immune protection from symptomatic SARS-CoV-2 infection
Predictive models of immune protection from COVID-19 are urgently needed to identify correlates of protection to assist in the future deployment of...
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Matrine Mediated Immune Protection in MS by Regulating Gut Microbiota and Production of SCFAs
There is clearly an unmet need for more effective and safer treatments for multiple sclerosis (MS). Our previous studies showed a significant...
