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Peroxiredoxins as Markers of Oxidative Stress in IgA Nephropathy, Membranous Nephropathy and Lupus Nephritis
IgA nephropathy (IgAN), membranous nephropathy (MN), and lupus nephritis (LN) represent important causes of chronic kidney disease. They belong to...
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The Association of HMGB1 and RAGE Gene Polymorphisms with IgA Vasculitis
High-mobility group box 1 (HMGB1) is a pleiotropic cytokine that propagates inflammation by its extracellular action of interacting with the receptor...
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Microorganisms in Pathogenesis and Management of IgA Vasculitis and IgA Nephropathy
IgA vasculitis is an autoimmune disease characterized by leukocyte infiltration into blood vessels. Infectious agents such as bacteria and viruses...
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Lupus nephritis or not? A simple and clinically friendly machine learning pipeline to help diagnosis of lupus nephritis
ObjectiveDiagnosis of lupus nephritis (LN) is a complex process, which usually requires renal biopsy. We aim to establish a machine learning pipeline...
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IgA vasculitis
IgA vasculitis (IgAV) is an inflammation of small vessels caused by perivascular deposition of IgA and activation of neutrophils. It may present as...
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Lupus Nephritis: New and Emerging Biologic and Targeted Therapies
Lupus nephritis (LN) is a severe complication of systemic lupus erythematosus (SLE), a polyclonal systemic autoimmunity directed against nuclear and...
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Angiotensin II Type 1 Receptor Antibodies Are Higher in Lupus Nephritis and Vasculitis than Other Glomerulonephritis Patients
Angiotensin II type 1 receptor (AT1R) antibodies are considered non-HLA (human leukocyte antigen) antibodies connected with humoral rejection after...
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Potential of bone morphogenetic protein-7 in treatment of lupus nephritis: addressing the hurdles to implementation
Up to 50% of systemic lupus erythematosus (SLE) patients world-wide develop lupus nephritis (LN). In low to middle income countries and in particular...
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Clinical Application of Polygenic Risk Score in IgA Nephropathy
Genome-wide association studies (GWASs) have identified 30 independent genetic variants associated with IgA nephropathy (IgAN). A genetic risk score...
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An Updated Focus on Immune Checkpoint Inhibitors and Tubulointerstitial Nephritis
One of the most relevant achievements in oncological research is represented by the development of a new category of anticancer drugs, the immune...
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Spatial proteomics landscape and immune signature analysis of renal sample of lupus nephritis based on laser-captured microsection
ObjectiveWe aimed to reveal a spatial proteomic and immune signature of kidney function regions in lupus nephritis (LN).
Material and methods ...
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Protopanaxadiol improves lupus nephritis by regulating the PTX3/MAPK/ERK1/2 pathway
Lupus nephritis (LN) is a kidney disease that occurs after systemic lupus erythematosus (SLE) affects the kidneys. Pentraxin 3 (PTX3) is highly...
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The influences of α-hemolytic Streptococcus on class switching and complement activation of human tonsillar cells in IgA nephropathy
While β-hemolytic streptococcus (β-HS) infections are known to predispose patients to acute poststreptococcal glomerulonephritis, there is evidence...
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Are there animal models of IgA nephropathy?
Immunoglobulin A (IgA) nephropathy (IgAN) is the most common primary glomerulonephritis worldwide. Up to 40% of IgAN patients develop end-stage...
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New Treatment Options in Lupus Nephritis
The aim of this study is to report major recent progresses in the treatment of lupus nephritis (LN). Results of controlled randomized trials are...
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Complement activation in IgA nephropathy
IgA nephropathy pathogenesis is incompletely understood, and this limits the development of disease-specific biomarkers and effective therapies....
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Omics are Getting Us Closer to Understanding IgA Nephropathy
During the last decade, thanks to omics technologies, new light has been shed on the pathogenesis of many diseases. Genomics, epigenomics,...
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Clinical relevance of glomerular IgM deposition in patients with lupus nephritis
BackgroundThe aim of the study was to investigate the clinical relevance of IgM deposition in patients with lupus nephritis (LN) in a large cohort.
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IgA glycosylation and immune complex formation in IgAN
IgA nephropathy (IgAN) is the most common primary glomerulonephritis worldwide. This disease, discovered in 1968, is characterized by IgA-IgG...
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Identifying potential biomarkers for the diagnosis and treatment of IgA nephropathy based on bioinformatics analysis
BackgroundIgA nephropathy (IgAN) has become the leading cause of end-stage renal disease in young adults. Nevertheless, the current diagnosis...
