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Polymorphisms in arsenic (+ 3 oxidation state) methyltransferase (AS3MT) predict the occurrence of hyperleukocytosis and arsenic metabolism in APL patients treated with As2O3
Polymorphisms in arsenic (+ 3 oxidation state) methyltransferase (AS3MT) have been shown to be related to interindividual variations in arsenic...
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Hematological, clinical, cytogenetic and molecular profiles of confirmed chronic myeloid leukemia patients at presentation at a tertiary care teaching hospital in Addis Ababa, Ethiopia: a cross-sectional study
BackgroundIn low-income countries there is insufficient evidence on hematological, clinical, cytogenetic and molecular profiles among new CML...
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The absolute number of leukocytes per vial as a major cause of early false positive blood cultures: proof-of-concept and application
Blood cultures detected as positive by the automated system but negative by microscopy and subculture are considered as “false-positives.” Several...
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Acute myeloid leukemia first presentation with central nervous system (CNS) involvement: a case report
BackgroundAcute myeloid leukemia (AML) typically presents with bone marrow myeloblast replacement, which can interfere with normal hematopoiesis. In...
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Molecular dissection of a hyper-aggressive CBFB-MYH11/FLT3-ITD–positive acute myeloid leukemia
Acute Myeloid Leukaemia (AML) is a haematological malignancy showing a hypervariable landscape of clinical outcomes and phenotypic differences,...
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Treatment outcomes of pediatrics acute myeloid leukemia (AML) and associated factors in the country’s tertiary referral hospital, Ethiopia
BackgroundPediatric Acute Myeloid Leukemia (AML) is a major cause of morbidity and mortality in children with cancer in Africa and other develo**...
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Ester tethered artemisinin-isatin hybrids: design, synthesis and anti-leukemic activity evaluation
A series of novel artemisinin-isatin hybrids ( 7a-t ) linked via different lengths of esters were designed, synthesized and evaluated for their...
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Norovirus-associated neurological manifestations: summarizing the evidence
Norovirus, a positive-stranded RNA virus, is one of the leading causes of acute gastroenteritis among all age groups worldwide. The neurological...
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An effective and chemotherapy-free strategy of all-trans retinoic acid and arsenic trioxide for acute promyelocytic leukemia in all risk groups (APL15 trial)
The combination of all-trans retinoic acid (ATRA) and arsenic trioxide (ATO) has been demonstrated to have comparable effectiveness or better to ATRA...
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A rare case of presumptive pleural toxocariasis
Toxocariasis is a cosmopolitan helminthiasis linked to contamination with Toxocara cati or Toxocara canis . Only six isolated cases of pleural...
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NOTCH1-Induced T-Cell Acute Lymphoblastic Leukemia In Vivo Models
T-cell acute lymphoblastic leukemia (T-ALL) is primarily a NOTCH1-driven disease, which represents approximately 15% of pediatric and 25% of adult...
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Impact of race on outcomes in intermediate-risk acute myeloid leukemia
PurposeRacial disparities in acute myeloid leukemia (AML) have been reported but the relative contribution of disease versus patient-specific factors...
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Influence on therapeutic outcome of platelet count at diagnosis in patients with de novo non-APL acute myeloid leukemia
BackgroundPlatelet (PLT) count at diagnosis plays an important role in cancer development and progression in solid tumors. However, it remains...
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Philadelphia chromosome positive chronic myeloid leukemia with 5q deletion at diagnosis
BackgroundAlthough, molecular genetic analyses became more and more important to guide therapy decisions in leukemia, banding cytogenetic analysis...
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Atp8a1 deletion increases the proliferative activity of hematopoietic stem cells by impairing PTEN function
PurposeThe eukaryotic cell plasma membrane contains several asymmetrically distributed phospholipids, which is maintained by the P4-ATPase flippase...
