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Hsa_circ_0003258 promotes prostate cancer metastasis by complexing with IGF2BP3 and sponging miR-653-5p
BackgroundMore and more studies have shown that circular RNAs (circRNAs) play a critical regulatory role in many cancers. However, the potential...
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Circulating circRNA as biomarkers for dilated cardiomyopathy etiology
AbstractDilated cardiomyopathy (DCM) is the third most common cause of heart failure. The multidisciplinary nature of testing — involving genetics,...
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Non-coding RNAs regulating mitochondrial function in cardiovascular diseases
Cardiovascular disease (CVD) is the leading cause of disease-related death worldwide and a significant obstacle to improving patients’ health and...
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The role of the methyltransferase METTL3 in prostate cancer: a potential therapeutic target
The incidence of prostate cancer (PCa), the most prevalent malignancy, is currently at the forefront. RNA modification is a subfield of the booming...
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Oncofetal protein IGF2BPs in human cancer: functions, mechanisms and therapeutic potential
N 6 -methyladenosine (m 6 A) is the most prevalent and well-characterized internal chemical modification in eukaryotic RNA, influencing gene expression...
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ALKBH5-mediated m6A modification of circCCDC134 facilitates cervical cancer metastasis by enhancing HIF1A transcription
BackgroundMetastasis is the main cause of mortality in cervical cancer (CC). Circular RNAs (circRNAs) have been demonstrated to play a crucial role...
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CircXRN2 suppresses tumor progression driven by histone lactylation through activating the Hippo pathway in human bladder cancer
BackgroundBladder cancer (BCa) is the fourth most common malignant tumor with a poor prognosis worldwide. Further exploration and research are needed...
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CircARID1A binds to IGF2BP3 in gastric cancer and promotes cancer proliferation by forming a circARID1A-IGF2BP3-SLC7A5 RNA–protein ternary complex
BackgroundGastric cancer (GC) is one of the most common malignant tumors in China. Circular RNAs (circRNAs) are novel non-coding RNAs with important...
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CircSMARCC1 facilitates tumor progression by disrupting the crosstalk between prostate cancer cells and tumor-associated macrophages via miR-1322/CCL20/CCR6 signaling
BackgroundCircular RNAs (circRNAs) mediate the infiltration of tumor-associated macrophages (TAMs) to facilitate carcinogenesis and development of...