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Precision-guided treatment in high-risk pediatric cancers
Recent research showed that precision medicine can identify new treatment strategies for patients with childhood cancers. However, it is unclear...
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Increased risk of contralateral breast cancer for BRCA1/2 wild-type, high-risk Korean breast cancer patients: a retrospective cohort study
BackgroundThis study aimed to investigate the contralateral breast cancer (CBC) recurrence rate in Korean breast cancer patients according to their BRCA1/2...
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Thrombogenetic Risk at High Altitude: Early Diagnosis and Treatment Modalities
Venous thrombosis (VT) is a complex preventable medical condition. Its manifestation depends on several acquired and inherited genetic risk factors....
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Modifiable risk factors in women at high risk of breast cancer: a systematic review
BackgroundModifiable risk factors (alcohol, smoking, obesity, hormone use, and physical activity) affect a woman’s breast cancer (BC) risk. Whether...
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Multiomic analysis identifies a high-risk signature that predicts early clinical failure in DLBCL
Recent genetic and molecular classification of DLBCL has advanced our knowledge of disease biology, yet were not designed to predict early events and...
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Aspects and outcomes of surveillance for individuals at high-risk of pancreatic cancer
Pancreatic ductal adenocarcinoma (PDAC) is a leading cause of cancer-related deaths and is associated with a poor prognosis. The majority of these...
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The prevalence and genotype distribution of high-risk human papillomaviruses among women in **anning, China
BackgroundThe persistent infection of high-risk Human papillomavirus(HPV) is considered the main cause of cervical intraepithelial neoplasia and...
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High-resolution map** of age- and gender-specific risk of Clonorchis sinensis infection risk in Guangdong, China: a geostatistical modeling study
BackgroundThe latest national survey on the distribution of human parasites in China demonstrated that Guangdong was among the endemic provinces with...
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Predicting the presence of coronary plaques featuring high-risk characteristics using polygenic risk scores and targeted proteomics in patients with suspected coronary artery disease
BackgroundThe presence of coronary plaques with high-risk characteristics is strongly associated with adverse cardiac events beyond the...
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Non-BRCA1/BRCA2 high-risk familial breast cancers are not associated with a high prevalence of BRCAness
BackgroundFamilial breast cancer is in most cases unexplained due to the lack of identifiable pathogenic variants in the BRCA1 and BRCA2 genes. The...
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Whole-exome sequencing reveals candidate high-risk susceptibility genes for endometriosis
BackgroundEndometriosis is a common, chronic disease among fertile-aged women. Disease course may be highly invasive, requiring extensive surgery....
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Practical Considerations for the Implementation and Monitoring of Risk Minimisation Measures for High-Risk Teratogenic Medicines
There is considerable societal interest in making medicines more affordable. A critical factor often inadequately considered early in the process of...
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The role of endoscopic ultrasound in the detection of pancreatic lesions in high-risk individuals
Individuals at high risk of develo** pancreatic ductal adenocarcinoma are eligible for surveillance within research programs. These programs employ...
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Prognostic refinement of NSMP high-risk endometrial cancers using oestrogen receptor immunohistochemistry
BackgroundRisk-assessment of endometrial cancer (EC) is based on clinicopathological factors and molecular subgroup. It is unclear whether adding...
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The Italian registry of families at risk for pancreatic cancer (IRFARPC): implementation and evolution of a national program for pancreatic cancer surveillance in high-risk individuals
Screening programs for early detection and treatment of pancreatic cancer (PC) and its precursor lesions are increasingly implemented worldwide to...
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Heterogeneity of clinical symptomatology in pediatric patients at clinical high risk for psychosis
ObjectiveWidespread use of diagnostic tools like the Structured Interview for Prodromal Symptoms (SIPS) has highlighted that youth at Clinical High...
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Adjuvant sintilimab in resected high-risk hepatocellular carcinoma: a randomized, controlled, phase 2 trial
Hepatocellular carcinoma (HCC), particularly when accompanied by microvascular invasion (MVI), has a markedly high risk of recurrence after liver...
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Updated 5-year results for short course abiraterone acetate and LHRH agonist for unfavorable intermediate and favorable high-risk prostate cancer
Combined androgen deprivation therapy (ADT) and radiotherapy (RT) improves outcomes for intermediate and high-risk prostate cancer. Treatment...
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Corticosteroids reduce pathologic interferon responses by downregulating STAT1 in patients with high-risk COVID-19
We do not yet understand exactly how corticosteroids attenuate hyperinflammatory responses and alleviate high-risk coronavirus disease 2019...
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Daratumumab-based quadruplet therapy for transplant-eligible newly diagnosed multiple myeloma with high cytogenetic risk
In the MASTER study (NCT03224507), daratumumab+carfilzomib/lenalidomide/dexamethasone (D-KRd) demonstrated promising efficacy in transplant-eligible...
