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An Optimized Protocol of Electroporation of Hepatocyte Nuclear Factor 1 Alpha (Hnf-1α) in Mesenchymal Stem Cells
AbstractThe objective of this study was to investigate the optimization of electroporation of hepatocyte nuclear factor 1 alpha ( Hnf-1 α) in murine...
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The role of hypoxia-inducible factor 1α in hepatic lipid metabolism
AbstractChronic liver disease is a major public health problem with a high and increasing prevalence worldwide. In the progression of chronic liver...
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The role of hypoxia-inducible factor 1 alpha (HIF-1α) modulation in heavy metal toxicity
Hypoxia-inducible factor 1 (HIF-1) is an oxygen-sensing transcriptional regulator orchestrating a complex of adaptive cellular responses to hypoxia....
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Protective effect of hepatocyte-enriched lncRNA-Mir122hg by promoting hepatocyte proliferation in acute liver injury
Some long noncoding RNAs (lncRNAs), which harbor microRNAs in their gene sequence and are also known as microRNA host gene derived lncRNAs...
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Fenofibrate alleviates NAFLD by enhancing the PPARα/PGC-1α signaling pathway coupling mitochondrial function
BackgroundTo comprehend the influences of fenofibrate on hepatic lipid accumulation and mitochondrial function-related signaling pathways in mice...
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A novel mechanistic approach for the anti-fibrotic potential of rupatadine in rat liver via amendment of PAF/NF-ĸB p65/TGF-β1 and hedgehog/HIF-1α/VEGF trajectories
Hepatic fibrosis is one of the major worldwide health concerns which requires tremendous research due to the limited outcomes of the current...
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Hepatocyte-derived VEGFA accelerates the progression of non-alcoholic fatty liver disease to hepatocellular carcinoma via activating hepatic stellate cells
Non-alcoholic fatty liver disease (NAFLD) is emerging as an epidemic risk factor for hepatocellular carcinoma (HCC). The progression of NAFLD to HCC...
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Hepatocyte organoids and cell transplantation: What the future holds
Historically, primary hepatocytes have been difficult to expand or maintain in vitro. In this review, we will focus on recent advances in...
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Significance of the Vitamin D Receptor on Crosstalk with Nuclear Receptors and Regulation of Enzymes and Transporters
The vitamin D receptor (VDR), in addition to other nuclear receptors, the pregnane X receptor (PXR) and constitutive androstane receptor (CAR), is...
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Expression dynamics of pregnane X receptor-controlled genes in 3D primary human hepatocyte spheroids
The pregnane X receptor (PXR) is a ligand-activated nuclear receptor controlling hepatocyte expression of numerous genes. Although expression changes...
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Optimized thyroid transcription factor-1 core promoter-driven microRNA-7 expression effectively inhibits the growth of human non-small-cell lung cancer cells
Targeted gene therapy has become a promising approach for lung cancer treatment. In our previous work, we reported that the targeted expression of...
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Flavonoids modulate AMPK/PGC-1α and interconnected pathways toward potential neuroprotective activities
As progressive, chronic, incurable and common reasons for disability and death, neurodegenerative diseases (NDDs) are significant threats to human...
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Role of Extracellular Vesicles in Cancer Pathogenesis
Extracellular vesicles (EVs) are cell-derived membranous vesicles necessary for intercellular communication. According to the size, biogenesis,...
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Hepatocyte high-mobility group box 1 protects against steatosis and cellular stress during high fat diet feeding
BackgroundCirculating high-mobility group box 1 (HMGB1) plays important roles in the pathogenesis of nonalcoholic fatty liver disease (NAFLD)....
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ATF3 in atherosclerosis: a controversial transcription factor
AbstractAtherosclerosis, the pathophysiological basis of most malignant cardiovascular diseases, remains a global concern. Transcription factors play...
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Cancer-associated fibroblast-secreted FGF7 as an ovarian cancer progression promoter
BackgroundOvarian cancer (OC) is distinguished by its aggressive nature and the limited efficacy of current treatment strategies. Recent studies have...
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Genomic Insights into Non-steroidal Nuclear Receptors in Prostate and Breast Cancer
Alterations in transcriptional programs are a fundamental feature of prostate (PCa) and breast cancerBreast cancers (BrCa), and frequently target the...
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Dynamic interplay of nuclear receptors in tumor cell plasticity and drug resistance: Shifting gears in malignant transformations and applications in cancer therapeutics
Recent advances have brought forth the complex interplay between tumor cell plasticity and its consequential impact on drug resistance and tumor...
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Natural compounds targeting nuclear receptors for effective cancer therapy
Human nuclear receptors (NRs) are a family of forty-eight transcription factors that modulate gene expression both spatially and temporally. Numerous...
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Modulation of hypoxia-inducible factor-1 signaling pathways in cancer angiogenesis, invasion, and metastasis by natural compounds: a comprehensive and critical review
Tumor cells employ multiple signaling mediators to escape the hypoxic condition and trigger angiogenesis and metastasis. As a critical orchestrate of...
