Search
Search Results
-
Microfluidic design for in-vitro liver zonation—a numerical analysis using COMSOL Multiphysics
The liver is one of the most important organs, with a complex physiology. Current in-vitro approaches are not accurate for disease modeling and drug...
-
-
Lyve-1 deficiency enhances the hepatic immune microenvironment entailing altered susceptibility to melanoma liver metastasis
BackgroundHyaluronan receptor LYVE-1 is expressed by liver sinusoidal endothelial cells (LSEC), lymphatic endothelial cells and specialized...
-
Kinetic Modeling of Hepatic Metabolism and Simulation of Treatment Effects
Mathematical modeling is a promising strategy to fill the experimentally unapproachable knowledge gaps about the relative contribution of various...
-
In vitro grafting of hepatic spheroids and organoids on a microfluidic vascular bed
With recent progress in modeling liver organogenesis and regeneration, the lack of vasculature is becoming the bottleneck in progressing our ability...
-
Multiplex Immunofluorescence for Detection of Spatial Distributions of Infiltrating T Cells Within Different Regions of Hepatic Lobules During Liver Transplantation Rejection
It remains unclear as to whether there are differences that exist in the types and functional status of immune cells within different areas of the...
-
Single-cell transcriptomic analysis reveals a novel cell state and switching genes during hepatic stellate cell activation in vitro
BackgroundThe transformation of hepatic stellate cell (HSC) to myofibroblast is a key event during liver fibrogenesis. However, the differentiation...
-
Peroxisome proliferator-activated receptor α agonist induces mouse hepatomegaly through the spatial hepatocyte enlargement and proliferation
Peroxisome proliferator-activated receptor alpha (PPARα) activation-induced hepatomegaly is accompanied by hepatocyte hypertrophy around the central...
-
Scalable production of tissue-like vascularized liver organoids from human PSCs
The lack of physiological parity between 2D cell culture and in vivo culture has led to the development of more organotypic models, such as...
-
The thrombopoietin mimetic JNJ-26366821 reduces the late injury and accelerates the onset of liver recovery after acetaminophen-induced liver injury in mice
Acetaminophen (APAP)-induced hepatotoxicity is comprised of an injury and recovery phase. While pharmacological interventions, such as N -acetylcystein...
-
Human Wharton's Jelly-derived mesenchymal stem cells prevent acetaminophen-induced liver injury in a mouse model unlike human dermal fibroblasts
The persistence of hepatotoxicity induced by N-acetyl-para-aminophenol (Acetaminophen or Paracetamol, abbreviated as APAP) as the most common cause...
-
Cross-species analysis of hepatic cytochrome P450 and transport protein expression
Most drugs and xenobiotics are metabolized in the liver. Amongst others, different cytochrome P450 (CYP) enzymes catalyze the metabolic conversion of...
-
Catecholamine induces Kupffer cell apoptosis via growth differentiation factor 15 in alcohol-associated liver disease
Chronic alcohol consumption often induces hepatic steatosis but rarely causes severe inflammation in Kupffer cells (KCs) despite the increased...
-
Comparative study on a novel lobule structure of the zebrafish liver and that of the mammalian liver
The mammalian liver has a lobule structure with a portal triad consisting of the portal vein, hepatic artery, and bile duct, which exhibits zonal...
-
Hepatic steatosis and steatohepatitis: a functional meta-analysis of sex-based differences in transcriptomic studies
BackgroundPrevious studies have described sex-based differences in the epidemiological and clinical patterns of non-alcoholic fatty liver disease...
-
Hepatocyte organoids and cell transplantation: What the future holds
Historically, primary hepatocytes have been difficult to expand or maintain in vitro. In this review, we will focus on recent advances in...
-
Array-based Western-blotting reveals spatial differences in hepatic signaling and metabolism following CAR activation
The complex three-dimensional architecture of the liver with its metabolically zonated lobules is a prerequisite to perform functions of metabolic...
-
A spatiotemporal atlas of cholestatic injury and repair in mice
Cholestatic liver injuries, characterized by regional damage around the bile ductular region, lack curative therapies and cause considerable...
-
Liver in infections: a single-cell and spatial transcriptomics perspective
The liver is an immune organ that plays a vital role in the detection, capture, and clearance of pathogens and foreign antigens that invade the human...
-
Inflammatory processes in the liver: divergent roles in homeostasis and pathology
The hepatic immune system is designed to tolerate diverse harmless foreign moieties to maintain homeostasis in the healthy liver. Constant priming...
