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A recombinant adenoviral vector with a specific tropism to CD4-positive cells: a new tool for HIV-1 inhibition
Gene therapy can be an option to overcome the side effects of chemotherapy and prevent the development of drug-resistant HIV viruses in HIV-infected...
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Leishmaniasis: Tissue Tropism in Relation to the Species Diversity
Leishmania is a vector-borne, obligatory, and anaerobic protozoan parasite that causes a spectrum of clinical conditions in its hosts. The disease...
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Identification of a novel HIV-1 third-generation circulating recombinant form (CRF126_0755) in Guangdong, China
The genetic recombination patterns and genetic distribution of HIV-1 are valuable for elucidating the epidemic and genetic diversity of HIV. Numerous...
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The chemokine receptor CCR5: multi-faceted hook for HIV-1
Chemokines are cytokines whose primary role is cellular activation and stimulation of leukocyte migration. They perform their various functions by...
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Molecular mechanisms by which the HIV-1 latent reservoir is established and therapeutic strategies for its elimination
The human immunodeficiency virus type 1 (HIV-1) reservoir, composed of cells harboring the latent, integrated virus, is not eliminated by...
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A large population sample of African HIV genomes from the 1980s reveals a reduction in subtype D over time associated with propensity for CXCR4 tropism
We present 109 near full-length HIV genomes amplified from blood serum samples obtained during early 1986 from across Uganda, which to our knowledge...
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In-depth virological and immunological characterization of HIV-1 cure after CCR5Δ32/Δ32 allogeneic hematopoietic stem cell transplantation
Despite scientific evidence originating from two patients published to date that CCR5Δ32/Δ32 hematopoietic stem cell transplantation (HSCT) can cure...
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Targeted shock-and-kill HIV-1 gene therapy approach combining CRISPR activation, suicide gene tBid and retargeted adenovirus delivery
Infections with the human immunodeficiency virus type 1 (HIV-1) are incurable due the long-lasting, latent viral reservoir. The shock-and-kill cure...
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Differences in neutralizing antibody sensitivities and envelope characteristics indicate distinct antigenic properties of Nigerian HIV-1 subtype G and CRF02_AG
The magnitude of the HIV-1 epidemic in Nigeria is second only to the subtype C epidemic in South Africa, yet the subtypes prevalent in Nigeria...
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Genetic characteristics of a novel HIV-1 recombinant lineage (CRF103_01B) and its prevalence in northern China
During the routine surveillance of HIV-1 pretreatment drug resistance in Bei**g, five men who have sex with men (MSM) and a woman were observed to...
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An HIV-1 broadly neutralizing antibody overcomes structural and dynamic variation through highly focused epitope targeting
The existence of broadly cross-reactive antibodies that can neutralize diverse HIV-1 isolates (bnAbs) has been appreciated for more than a decade....
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Inhibition of caspase pathways limits CD4+ T cell loss and restores host anti-retroviral function in HIV-1 infected humanized mice with augmented lymphoid tissue
The study of HIV infection and pathogenicity in physical reservoirs requires a biologically relevant model. The human immune system (HIS) mouse is an...
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Neurodegeneration Associated with HIV-1 in the Era of cART
Infection with human immunodeficiency virus (HIV)-1 targets not only cells of the immune system and eventually causes AIDS, but also triggers...
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Neurodegeneration Associated with HIV-1 in the Era of cART
Infection with human immunodeficiency virus (HIV)-1 targets not only cells of the immune system and eventually causes AIDS, but also triggers...
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Longitudinal analysis of subtype C envelope tropism for memory CD4+ T cell subsets over the first 3 years of untreated HIV-1 infection
BackgroundHIV-1 infects a wide range of CD4 + T cells with different phenotypic properties and differing expression levels of entry coreceptors. We...
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Antiretroviral action of Rosemary oil-based atazanavir formulation and the role of self-nanoemulsifying drug delivery system in the management of HIV-1 infection
Atazanavir or ATV is an FDA-approved, HIV-1 protease inhibitor that belongs to the azapeptide group. Over time, it has been observed that ATV can...
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Construction and Characterization of HIV-1 env-Pseudoviruses of the Recombinant Form CRF63_02A and Subtype A6
HIV-1 env -pseudoviruses are a useful tool in the search for antiviral drugs (entry inhibitors) and evaluation of the efficacy of HIV-1 vaccines....
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Replication-competent HIV-1 in human alveolar macrophages and monocytes despite nucleotide pools with elevated dUTP
BackgroundAlthough CD4 + memory T cells are considered the primary latent reservoir for HIV-1, replication competent HIV has been detected in tissue...
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Single-cell RNA sequencing reveals the immune features and viral tropism in the central nervous system of mice infected with Japanese encephalitis virus
Japanese encephalitis virus (JEV) is a neurotropic pathogen that causes lethal encephalitis. The high susceptibility and massive proliferation of JEV...
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Persistent immunogenicity of integrase defective lentiviral vectors delivering membrane-tethered native-like HIV-1 envelope trimers
Integrase Defective Lentiviral Vectors (IDLVs) represent an attractive vaccine platform for delivering HIV-1 antigens, given their ability to induce...
