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Viral and host mediators of non-suppressible HIV-1 viremia
Non-suppressible HIV-1 viremia (NSV) is defined as persistent low-level viremia on antiretroviral therapy (ART) without evidence of ART non-adherence...
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Molecular epidemiology of the HIV-1 epidemic in Fiji
Very little is known about the HIV-1 epidemic in Fiji, nor the wider South Pacific region more generally, yet new reported HIV-1 infections are on...
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Dynamics and durability of HIV-1 neutralization are determined by viral replication
Human immunodeficiency virus type 1 (HIV-1)-neutralizing antibodies (nAbs) that prevent infection are the main goal of HIV vaccine discovery. But as...
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The cell biology of HIV-1 latency and rebound
Transcriptionally latent forms of replication-competent proviruses, present primarily in a small subset of memory CD4 + T cells, pose the primary...
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Characterization of an imported HIV-1 A1/A7/G recombinant in China
BackgroundInternational migration has accelerated the HIV-1 spread across national borders, gradually reducing the restrictions on the geographical...
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In situ analysis of neuronal injury and neuroinflammation during HIV-1 infection
BackgroundSince the introduction of combination antiretroviral therapy (cART) the brain has become an important human immunodeficiency virus (HIV)...
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Molecular Mechanisms of HIV-1 Latency from a Chromatin and Epigenetic Perspective
Purpose of ReviewThe main obstacle to an HIV-1 cure is the reservoir of HIV-1 infected cells. While antiretroviral therapy (ART) eliminates the HIV-1...
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Defective HIV-1 genomes and their potential impact on HIV pathogenesis
Defective HIV-1 proviruses represent a population of viral genomes that are selected for by immune pressures, and clonally expanded to dominate the...
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Assessing immunogenicity barriers of the HIV-1 envelope trimer
Understanding the balance between epitope shielding and accessibility on HIV-1 envelope (Env) trimers is essential to guide immunogen selection for...
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Immunoescape of HIV-1 in Env-EL9 CD8 + T cell response restricted by HLA-B*14:02 in a Non progressor who lost twenty-seven years of HIV-1 control
BackgroundLong-Term Non-Progressors (LTNPs) are untreated Human Immunodeficiency virus type 1 (HIV-1) infected individuals able to control disease...
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Triple tandem trimer immunogens for HIV-1 and influenza nucleic acid-based vaccines
Recombinant native-like HIV-1 envelope glycoprotein (Env) trimers are used in candidate vaccines aimed at inducing broadly neutralizing antibodies....
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Strategies for HIV-1 vaccines that induce broadly neutralizing antibodies
After nearly four decades of research, a safe and effective HIV-1 vaccine remains elusive. There are many reasons why the development of a potent and...
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Recombinant characteristics of three novel HIV-1 second-generation recombinant forms composed of CRF01_AE and CRF07_BC isolated in Hebei province, China
Human immunodeficiency virus 1 (HIV-1) is a fast-evolving, genetically diverse virus. The HIV-1 evolution rate is also significantly influenced by...
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Identification and genomic characterization of a novel HIV-1 unique recombinant form (CRF01_AE/CRF07_BC) in Zhejiang Province, China
Mutation and recombination are important mechanisms leading to the frequent evolution and genetic diversity of viruses as HIV-1. In this study, we...
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HIV-1 restriction by SERINC5
Serine incorporator 5 (SERINC5 or SER5) is a multipass transmembrane protein with ill-defined cellular activities. SER5 was recently described as a...
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A clinical review of HIV integrase strand transfer inhibitors (INSTIs) for the prevention and treatment of HIV-1 infection
Integrase strand transfer inhibitors (INSTIs) have improved the treatment of human immunodeficiency virus (HIV). There are currently four approved...
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Neutralization titer biomarker for antibody-mediated prevention of HIV-1 acquisition
The Antibody Mediated Prevention trials showed that the broadly neutralizing antibody (bnAb) VRC01 prevented acquisition of human immunodeficiency...
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HIV-1 infection of renal epithelial cells: 30 years of evidence from transgenic animal models, human studies and in vitro experiments
Although antiretroviral therapy (ART) has increased life expectancy in people with HIV-1 (PWH), acute and chronic kidney disease remain common in...
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Genetic characterization of varicella-zoster and HIV-1 viruses from the cerebrospinal fluid of a co-infected encephalitic patient, Ghana
BackgroundEncephalitis is a serious disease of the brain characterized by prodromal and specific neurological symptoms. HIV infections offer...
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HIV-1 subtype C Tat exon-1 amino acid residue 24K is a signature for neurocognitive impairment
Variation and differential selection pressures on Tat genes have been shown to alter the biological function of the protein, resulting in...
