Search
Search Results
-
Silencing HE4 alleviates the renal fibrosis in lupus nephritis mice by regulating the C3/MMPs/prss axis
To explore the regulatory effect of human epididymis protein 4 (HE4) on renal fibrosis in mice with lupus nephritis (LN) and the underlying...
-
HE4 as a serum biomarker for the diagnosis of pelvic masses: a prospective, multicenter study in 965 patients
BackgroundTo evaluate the diagnostic value of adding human epididymis protein 4 (HE4), cancer antigen 125 (CA125) and risk of malignancy algorithm...
-
YWHAE as an HE4 interacting protein can influence the malignant behaviour of ovarian cancer by regulating the PI3K/AKT and MAPK pathways
BackgroundMalignant tumours of the female reproductive system threaten the lives and health of women worldwide, with ovarian cancer having the...
-
ZNF703 promotes tumor progression in ovarian cancer by interacting with HE4 and epigenetically regulating PEA15
BackgroundIt is known that the transcription factor zinc finger protein 703 (ZNF703) plays an important role in physiological functions and the...
-
HE4 overexpression decreases pancreatic cancer Capan-1 cell sensitivity to paclitaxel via cell cycle regulation
BackgroundPaclitaxel is a first-line chemotherapy drug for pancreatic, ovarian, endometrial cancers and other malignancies. However, its efficacy is...
-
Autoantibodies, antigen-autoantibody complexes and antigens complement CA125 for early detection of ovarian cancer
BackgroundMultiple antigens, autoantibodies (AAb), and antigen-autoantibody (Ag-AAb) complexes were compared for their ability to complement CA125...
-
Interaction of HE4 and ANXA2 exists in various malignant cells—HE4–ANXA2–MMP2 protein complex promotes cell migration
BackgroundThe interaction between human epididymis protein 4 (HE4) and annexin A2 (Annexin A2) has been found in ovarian cancer. However, it is...
-
An analysis of clinical characteristics and prognosis of endometrioid ovarian cancer based on the SEER database and two centers in China
PurposeTo assess the clinical characteristics and the risk factors related to the unfavorable prognosis of endometrioid ovarian carcinoma (EOVC)...
-
Biomarker-based early detection of epithelial ovarian cancer based on a five-protein signature in patient’s plasma – a prospective trial
BackgroundTrial on five plasma biomarkers (CA125, HE4, OPN, leptin, prolactin) and their possible role in differentiating benign from malignant...
-
Correlation of clinicopathological and prognostic characteristics between endometriosis-associated and primary ovarian cancer
BackgroundThe main aim of this study was to establish the clinicopathological and prognostic correlations between endometriosis-associated and...
-
Plasma circN4BP2L2 is a promising novel diagnostic biomarker for epithelial ovarian cancer
BackgroundCircular RNAs (circRNAs) are more stable than linear RNA molecules, which makes them promising diagnostic biomarkers for diseases. By...
-
Diagnostic value of circN4BP2L2 in type I and type II epithelial ovarian cancer
BackgroundCircN4BP2L2 was previously identified to be significantly decreased in epithelial ovarian cancer (EOC) and was associated with disease...
-
Early detection of colorectal neoplasia: application of a blood-based serological protein test on subjects undergoing population-based screening
BackgroundBlood-based biomarkers used for colorectal cancer screening need to be developed and validated in appropriate screening populations. We...
-
Elucidating the role of liver enzymes as markers and regulators in ovarian cancer: a synergistic approach using Mendelian randomization, single-cell analysis, and clinical evidence
ObjectiveTo investigate the association between liver enzymes and ovarian cancer (OC), and to validate their potential as biomarkers and their...
-
Applying low coverage whole genome sequencing to detect malignant ovarian mass
To evaluate whether low coverage whole genome sequencing is suitable for the detection of malignant pelvic mass and compare its diagnostic value with...
-
Tissue HE4 Expression Discriminates the Ovarian Serous Carcinoma but Not the Uterine Serous Carcinoma Patients. A New Adjunct to the Origin of the Tumor Site
Both uterine serous carcinoma (USC) and ovarian serous carcinoma (OSC) are presented at advanced stage at the first admittion and dissseminated...
-
Fibrinogen/albumin ratio as a promising predictor of platinum response and survival in ovarian clear cell carcinoma
BackgroundThis study aims to evaluate the role of the fibrinogen/albumin ratio (FAR) in predicting platinum resistance and survival outcomes of...
-
Prospective evaluation of 92 serum protein biomarkers for early detection of ovarian cancer
BackgroundCA125 is the best available yet insufficiently sensitive biomarker for early detection of ovarian cancer. There is a need to identify novel...
-
Clinical characteristics and prognosis of ovarian clear cell carcinoma: a 10-year retrospective study
BackgroundOvarian clear cell carcinoma (OCCC) is a special pathological type of epithelial ovarian carcinoma (EOC). We conducted this research to...
-
Comparison of the ADNEX and ROMA risk prediction models for the diagnosis of ovarian cancer: a multicentre external validation in patients who underwent surgery
BackgroundSeveral diagnostic prediction models to help clinicians discriminate between benign and malignant adnexal masses are available. This study...
