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Pituitary P62 deficiency leads to female infertility by impairing luteinizing hormone production
P62 is a protein adaptor for various metabolic processes. Mice that lack p62 develop adult-onset obesity. However, investigations on p62 in...
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Bruce D. Goldman
Bruce D. Goldman (b.1940) trained as an endocrinologist at the University of Wisconsin, the Medical College of Georgia, the University of Texas...
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Androgen-induced gut dysbiosis disrupts glucolipid metabolism and endocrinal functions in polycystic ovary syndrome
BackgroundThe characteristics of polycystic ovary syndrome (PCOS), a common reproductive endocrinal disorder, are high incidence, complicated...
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Short and long-term 2100 MHz radiofrequency radiation causes endoplasmic reticulum stress in rat testis
Long-term radiofrequency radiation (RFR) exposure, which adversely affects organisms, deteriorates testicular functions. Misfolding or unfolding...
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Potential clinical application of anti-Müllerian hormone testing in radioiodine treatment of thyroid carcinoma
Differentiated thyroid cancer is the most common endocrinological malignancy. Radioiodine treatment has a clear benefit in locally aggressive and...
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Management after initial surgery of nonfunctioning pituitary adenoma: surveillance, radiotherapy or surgery?
IntroductionThe first line of treatment for nonfunctioning pituitary adenoma (NFPA) is surgery. Adjuvant radiotherapy or surveillance and new...
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Perinatal Inflammation Reprograms Neuroendocrine, Immune, and Reproductive Functions: Profile of Cytokine Biomarkers
Viral and bacterial infections causing systemic inflammation are significant risk factors for develo** body. Inflammatory processes can alter...
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Ultrasound of the Reproductive System
This chapter reviews the basic anatomy and physiology of adult male and female reproduction, including the regulation of physiological functions by...
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Estrogen signaling via estrogen receptor alpha and its implications for neurodegeneration associated with Alzheimer’s disease in aging women
Estrogen receptor alpha (ERα) is a transcription factor activated by estrogenic hormones to regulate gene expression in certain organs, including the...
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The Level of Sex Hormones and Corticosterone in Female Rats during Modeling of Visceral Obesity, Subsequent Physical Activity, and Normalization of the Diet
The effects of diet-induced visceral obesity and non-drug options of its correction on the level of sex hormones and corticosterone were evaluated in...
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Testosterone Levels Are Decreased and Associated with Disease Duration in Male Spinocerebellar Ataxia Type 2 Patients
Spinocerebellar ataxia type 2 (SCA2) is a progressive neurodegenerative disorder due to an unstable expansion of a CAG repeat in the ATXN2 gene....
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Oxidative Stress and Male Infertility: Role of Herbal Drugs
Infertility is a universal health problem affecting 15% of couples, out of which 20–30% cases are due to male infertility. The leading causes of male...
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Genes of Hormone Receptors Affecting Egg Productivity and Reproductive Qualities of Chickens
AbstractThe egg production of chickens is a complex polygenic type of inheritance and is controlled by many genes. The laying performance of chickens...
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Updates on the mechanisms of toxicities associated with monoclonal antibodies targeting growth factor signaling and immune cells in cancer
Monoclonal antibody (mAb)-based immunotherapy currently is considered to be an optimal therapeutic approach to cancer treatment, either in...
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Ataxia and Hypogonadism: a Review of the Associated Genes and Syndromes
The association of hypogonadism and cerebellar ataxia was first recognized in 1908 by Gordon Holmes. Since the seminal description, several...
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The ethanolic extract of Aframomum angustifolium seeds protects against tamoxifen-induced side effects in rats with breast cancer
Long-term use of tamoxifen (TAM) is associated with severe side effects. The present study aimed at evaluating the protective effect of the ethanolic...
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Medulloblastomas in Pediatric and Adults
MedulloblastomaMedulloblastoma is the primary malignantMalignant embryonic tumor of the cerebellumCerebellum and the most common malignantMalignant...
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DNA methylome profiling of granulosa cells reveals altered methylation in genes regulating vital ovarian functions in polycystic ovary syndrome
BackgroundWomen with polycystic ovary syndrome (PCOS) manifest a host of ovarian defects like impaired folliculogenesis, anovulation, and poor oocyte...
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Protective role of melatonin in breast cancer: what we can learn from women with blindness
PurposeThis review proposes an overall vision of the protective and therapeutic role of melatonin in breast cancer: from the specific cases of blind...
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Effects of COVID-19 on the Course of Epilepsy
A comparative analysis of two case histories showing the effects of COVID-19 and immunization with the Sputnik V vaccine on the dynamics of epilepsy...