Search
Search Results
-
A Novel Integrated Pipeline for Site-Specific Quantification of N-glycosylation
The site-specific N-glycosylation changes of human plasma immunoglobulin gamma molecules (IgGs) have been shown to modulate the immune response and...
-
Glycosylation as a regulator of site-specific metastasis
Metastasis is considered to be responsible for 90% of cancer-related deaths. Although it is clinically evident that metastatic patterns vary by...
-
Genetics of glycosylation in mammalian development and disease
Glycosylation of proteins and lipids in mammals is essential for embryogenesis and the development of all tissues. Analyses of glycosylation mutants...
-
Defining albumin as a glycoprotein with multiple N-linked glycosylation sites
BackgroundGlycosylation is an enzyme-catalyzed post-translational modification that is distinct from glycation and is present on a majority of plasma...
-
Mass spectrometry analysis of intact protein N-glycosylation signatures of cells and sera in pancreatic adenocarcinomas
Pancreatic cancer is among the most malignant cancers, and thus early intervention is the key to better survival outcomes. However, no methods have...
-
Identification of stemness-related glycosylation changes in head and neck squamous cell carcinoma
BackgroundAltered glycosylation is a hallmark of cancer associated with therapy resistance and tumor behavior. In this study, we investigated the...
-
The glycosylation deficiency of flavivirus NS1 attenuates virus replication through interfering with the formation of viral replication compartments
BackgroundFlavivirus is a challenge all over the world. The replication of flavivirus takes place within membranous replication compartments (RCs)...
-
An association of CSF apolipoprotein E glycosylation and amyloid-beta 42 in individuals who carry the APOE4 allele
Carrying the apolipoprotein E (ApoE) Ɛ4 allele is associated with an increased risk of cerebral amyloidosis and late-onset Alzheimer’s disease, but...
-
circ-hnRNPU inhibits NONO-mediated c-Myc transactivation and mRNA stabilization essential for glycosylation and cancer progression
BackgroundRecent evidence reveals the emerging functions of circular RNA (circRNA) and protein glycosylation in cancer progression. However, the...
-
Abnormal expression of lysosomal glycoproteins in patients with congenital disorders of glycosylation
ObjectiveThe study of the impact of some inherited defects in glycosylation on the biosynthesis of some lysosomal glycoproteins. Results description:...
-
Nucleotide sugar transporter SLC35A2 is involved in promoting hepatocellular carcinoma metastasis by regulating cellular glycosylation
PurposeRecently, aberrant glycosylation has been recognized to be relate to malignant behaviors of cancer and outcomes of patients with various...
-
Development and validation of a model and nomogram for breast cancer diagnosis based on quantitative analysis of serum disease-specific haptoglobin N-glycosylation
BackgroundA better diagnostic marker is in need to distinguish breast cancer from suspicious breast lesions. The abnormal glycosylation of...
-
Glycosylation-related genes mediated prognostic signature contribute to prognostic prediction and treatment options in ovarian cancer: based on bulk and single‑cell RNA sequencing data
BackgroundOvarian cancer (OC) is a complex disease with significant tumor heterogeneity with the worst prognosis and highest mortality among all...
-
Finding the sweet spot: glycosylation mediated regulation of intestinal inflammation
Glycans are essential cellular components that facilitate a range of critical functions important for tissue development and mucosal homeostasis....
-
The role of N-linked glycosylation in proteolytic processing and cell surface transport of the Cedar virus fusion protein
BackgroundN-linked glycans on viral glycoproteins have been shown to be important for protein expression, processing and intracellular transport. The...
-
Elevated transcription and glycosylation of B3GNT5 promotes breast cancer aggressiveness
BackgroundBasal-like breast cancer (BLBC) is the most aggressive subtype of breast cancer because of its aggressive biological characteristics and no...
-
An N-glycoproteomic site-map** analysis reveals glycoprotein alterations in esophageal squamous cell carcinoma
BackgroundAberrant glycosylation has been recognized as a hallmark of cancer and N-glycosylation is one of the main types of glycosylation in...
-
Abnormal Glycosylation in Cancer Cells and Cancer Stem Cells as a Therapeutic Target
Tumor resistance and recurrence have been associated with the presence of cancer stem cells (CSCs) in tumors. The functions and survival of the CSCs...
-
SLC10A7, an orphan member of the SLC10 family involved in congenital disorders of glycosylation
SLC10A7, encoded by the so-called SLC10A7 gene, is the seventh member of a human sodium/bile acid cotransporter family, known as the SLC10 family....
-
Glycosylation of Plant-Produced Immunoglobulins
Many economically important protein-based therapeutics like monoclonal antibodies are glycosylated. Due to the recognized importance of this type of...