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Involvement of Autophagy in the Protective Effects of Ginsenoside Rb1 in a Rat Model of Traumatic Brain Injury
Background and ObjectivesNo treatment modalities have been identified to prevent neuron damage induced by traumatic brain injury (TBI). The objective...
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Ginsenoside Rb1 alleviates diabetic kidney podocyte injury by inhibiting aldose reductase activity
Panax notoginseng , a traditional Chinese medicine, exerts beneficial effect on diabetic kidney disease (DKD), but its mechanism is not well...
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Biotransformation of ginsenoside Rb1 and Rd to four rare ginsenosides and evaluation of their anti-melanogenic effects
Improving physiological activity of primary ginsenosides through biotransformation is of great significance for food applications. In this study,...
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Integrative informatics analysis identifies that ginsenoside Re improves renal fibrosis through regulation of autophagy
We previously demonstrated that ginsenoside Re (G-Re) has protective effects on acute kidney injury. However, the underlying mechanism is still...
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Ginsenoside Rb1 induces a pro-neurogenic microglial phenotype via PPARÎł activation in male mice exposed to chronic mild stress
BackgroundAnti-inflammatory approaches are emerging as a new strategy for the treatment of depressive disorders. Ginsenoside Rb1 (GRb1), a major...
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Ginsenoside Rb1 alleviates colitis in mice via activation of endoplasmic reticulum-resident E3 ubiquitin ligase Hrd1 signaling pathway
Endoplasmic reticulum (ER) homeostasis is regulated by ER-resident E3 ubiquitin ligase Hrd1, which has been implicated in inflammatory bowel disease...
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Ginsenoside Rg1 in neurological diseases: From bench to bedside
Ginseng has been used in China as a superior medicinal material for thousands of years that can nourish the five internal organs, calm the mind and...
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Ginsenoside Compound K Promotes Proliferation, Migration and Differentiation of Schwann Cells via the Activation of MEK/ERK1/2 and PI3K/AKT Pathways
The proliferation and differentiation of Schwann cells are critical for the remyelination of injured peripheral nerve. Ginsenoside compound K (CK) is...
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Anti-skin-aging effects of tissue-cultured mountain-grown ginseng and quantitative HPLC/ELSD analysis of major ginsenosides
Mountain-grown ginseng has free radical scavenging activity and suppresses inflammation. We evaluated the anti-skin-aging effects of tissue-cultured...
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Effects of red ginseng extract on the pharmacokinetics and disposition of warfarin via intestinal Cyp2c11 modulation in rats
PurposeThis study aimed to develop and validate the analytical method for warfarin and its major metabolite 7-hydroxy warfarin using liquid...
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UFLC–MS/MS Determination and Population Pharmacokinetic Study of Tanshinol, Ginsenoside Rb1 and Rg1 in Rat Plasma After Oral Administration of Compound Danshen Drip** Pills
Background and ObjectivesAs a traditional Chinese Materia Medica (CMM), the Compound Danshen Drip** Pill (CDDP) is widely used for the treatments...
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Components of Salvia miltiorrhiza and Panax notoginseng Protect Pericytes Against OGD/R-Induced Injury via Regulating the PI3K/AKT/mTOR and JNK/ERK/P38 Signaling Pathways
Salvia miltiorrhiza (SAL) and Panax notoginseng (PNS) are widely used in treating of ischemic stroke. However, it is unknown which components of SAL...
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Recent trends in ginseng research
Ginseng, the dried root of Panax ginseng , contains ginsenosides and has long been used in Korea, China, and Japan to treat various symptoms. Many...
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Variable Selection Based on Gray Wolf Optimization Algorithm for the Prediction of Saponin Contents in Xuesaitong Drop** Pills Using NIR Spectroscopy
PurposeA rapid quantification method for the five saponins was developed based on near infrared (NIR) spectroscopy as a quality control strategy for...
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Genetic diversity of Panax ginseng cultivated in Japan and its relation with some plant characteristics
In East Asia, Panax ginseng is one of the most important medicinal plants and has been used in traditional medicines from ancient times. Today, P....
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Promoting oral absorption of Panax notoginseng saponins via thiolated trimethyl chitosan and wheat germ agglutinin–modified nanoformulation
This study aimed to enhance the oral absorption of Panax notoginseng saponins (PNS) via nanoparticles modified with thiolated trimethyl chitosan...
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Protopanaxadiol improves lupus nephritis by regulating the PTX3/MAPK/ERK1/2 pathway
Lupus nephritis (LN) is a kidney disease that occurs after systemic lupus erythematosus (SLE) affects the kidneys. Pentraxin 3 (PTX3) is highly...
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A Proliferation-Inducing Ligand Regulation in Polymorphonuclear Neutrophils by Panax ginseng
A proliferation-inducing ligand (APRIL) is a member of the tumor necrosis factor superfamily that was first identified as a factor favoring...
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Protective effects of Panax ginseng as a medical food against chemical toxic agents: molecular and cellular mechanisms
Humans are exposed to different types of toxic agents, which may directly induce organ malfunction or indirectly alter gene expression, leading to...
