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The Complete Genomic Sequence of Microbial Transglutaminase Producer, Streptomyces mobaraensis DSM40587
Actinomycetes are remarkable natural sources of active natural molecules and enzymes of considerable industrial value. Streptomyces mobaraensis is...
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Genomic sequence capture of Plasmodium relictum in experimentally infected birds
BackgroundSequencing parasite genomes in the presence of host DNA is challenging. Sequence capture can overcome this problem by using RNA probes that...
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Genomic Ancestry as Biomarkers
The influence of ethnicity on diabetic retinopathy has been studied for decades with controversial results. Different populations report different...
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Comprehensive whole-genome sequence analyses provide insights into the genomic architecture of cerebral palsy
We performed whole-genome sequencing (WGS) in 327 children with cerebral palsy (CP) and their biological parents. We classified 37 of 327 (11.3%)...
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Screening Host Genomic Data for Wolbachia Infections
Less than a decade ago, the production of Wolbachia genomic assemblies was tedious, time-consuming, and expensive. The production of Wolbachia...
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Genomic analysis of the international high-risk clonal lineage Klebsiella pneumoniae sequence type 395
BackgroundKlebsiella pneumoniae , which is frequently associated with hospital- and community-acquired infections, contains multidrug-resistant...
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Sequence Alignment
Sequence alignment is an essential computational step before performing evolutionary analysis of genomic sequences and structural analysis of...
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Construction of Genomic and Sub-Genomic Dengue Infectious Replicons
Dengue replicons are powerful tools used in studying virus biology as well as in high-throughput screening of drug candidates. Replicon constructs...
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Sequence dependencies and mutation rates of localized mutational processes in cancer
BackgroundCancer mutations accumulate through replication errors and DNA damage coupled with incomplete repair. Individual mutational processes often...
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The complete genome sequence of tomato necrotic ringspot virus in chilli in Thailand derived from next-generation sequencing
Tomato necrotic ringspot virus (TNRV) was first reported in Thailand in 2011, where it continues to reduce the yield and quality of pepper and tomato...
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Complete genome sequence of a novel robigovirus infecting Mentha arvensis
The complete genomic sequence of a novel robigovirus, provisionally named “Mentha arvensis robigovirus 1” (MARV1), was determined by combining...
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Genomic Ancestry as Biomarkers
The influence of ethnicity on diabetic retinopathy has been studied for decades with controversial results. Different populations report different...
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Personal transcriptome variation is poorly explained by current genomic deep learning models
Genomic deep learning models can predict genome-wide epigenetic features and gene expression levels directly from DNA sequence. While current models...
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Oncogenic Genomic Changes in Cancer
A common cause of all cancers leads us to a common definition. This definition is mutation. Cancer cells tend to constantly resist irregularity under...
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Benchmarking of deep neural networks for predicting personal gene expression from DNA sequence highlights shortcomings
Deep learning methods have recently become the state of the art in a variety of regulatory genomic tasks
1 –6 , including the prediction of gene...
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Genomic Mosaicism of the Brain: Origin, Impact, and Utility
Genomic mosaicism describes the phenomenon where some but not all cells within a tissue harbor unique genetic mutations. Traditionally, research...
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Genomic surveillance for antimicrobial resistance — a One Health perspective
Antimicrobial resistance (AMR) — the ability of microorganisms to adapt and survive under diverse chemical selection pressures — is influenced by...
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Genomic Instability in Carcinogenesis
Genomic instability is one of the hallmarks of cancer. Several theories have been put forth to ascertain this departure from the normal state as...
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Genomic newborn screening for rare diseases
Rare diseases are a leading cause of infant mortality and lifelong disability. To improve outcomes, timely diagnosis and effective treatments are...
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The value of genomic testing in severe childhood speech disorders
With increasing gene discoveries for severe speech disorders, genomic testing can alter the diagnostic and clinical paradigms, enabling better life...
