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Vaccine Innovation Meta-Model for Pandemic Contexts
PurposeOver the past decade, successive outbreaks and epidemics of infectious diseases have challenged the emergency preparedness and response...
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Genomic innovation and regulatory rewiring during evolution of the cotton genus Gossypium
Phenotypic diversity and evolutionary innovation ultimately trace to variation in genomic sequence and rewiring of regulatory networks. Here, we...
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The Impact of US Medical Product Regulatory Complexity on Innovation: Preliminary Evidence of Interdependence, Early Acceleration, and Subsequent Inversion
PurposeIs the complexity of medical product (medicines and medical devices) regulation impacting innovation in the US? If so, how?
Methods ...
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The expanding diagnostic toolbox for rare genetic diseases
Genomic technologies, such as targeted, exome and short-read genome sequencing approaches, have revolutionized the care of patients with rare genetic...
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Genetic basis of STEM occupational choice and regional economic performance: a UK biobank genome-wide association study
BackgroundScience, technology, engineering, and mathematics (STEM) professionals are regarded as the highly skilled labor force that fosters economic...
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Multi-faceted CRISPR/Cas technological innovation aspects in the framework of 3P medicine
Since 2009, the European Association for Predictive, Preventive and Personalised Medicine (EPMA, Brussels) promotes the paradigm change from reactive...
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Forensic Science Innovation in the UK: Roadblocks and Enablers
Forensic science is an innovative discipline that seeks to address the challenges of crime reconstruction. Innovation has enhanced the accuracy,...
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The potential and translational application of infant genetic research
In the current genomic revolution, the infancy life stage is the most neglected. Although clinical genetics recognizes the value of early...
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An exemplary model of genetic counselling for highly specialised services
With genomic testing being increasingly integrated into every day clinical practice and a wide range of practitioners ordering genetic tests, it is...
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Innovation Through the Liaison with Academia and End Users
This chapter discusses the importance of establishing dialogue between academia (one of the innovation stakeholders) and the end-users (the...
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Guidelines for genetic testing in prostate cancer: a sco** review
BackgroundGenetic testing, to identify pathogenic or likely pathogenic variants in prostate cancer, is valuable in guiding treatment decisions for...
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Scaling-up and future sustainability of a national reproductive genetic carrier screening program
An understanding of factors influencing implementation is essential to realise the benefits of population-based reproductive genetic carrier...
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Harnessing deep learning for population genetic inference
In population genetics, the emergence of large-scale genomic data for various species and populations has provided new opportunities to understand...
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The Randomised Controlled Trial at the Intersection of Research Ethics and Innovation
The randomised controlled trial (RCT) has been considered for a long time as the gold standard for evidence generation to support regulatory decision...
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Recent advances in CRISPR-based functional genomics for the study of disease-associated genetic variants
Advances in sequencing technology have greatly increased our ability to gather genomic data, yet understanding the impact of genetic mutations,...
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Isoform-level transcriptome-wide association uncovers genetic risk mechanisms for neuropsychiatric disorders in the human brain
Methods integrating genetics with transcriptomic reference panels prioritize risk genes and mechanisms at only a fraction of trait-associated genetic...
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CRISPR for Rewriting Genetic Code
Rewriting the genetic code has always been a big desire of researchers and scientists working in the field of life sciences. Manipulating DNA...
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Preimplantation genetic testing for aneuploidy: challenges in clinical practice
Preimplantation genetic testing for aneuploidy (PGT-A) has been used widely during in vitro fertilization procedures in assisted reproductive centers...