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Precise modulation of transcription factor levels identifies features underlying dosage sensitivity
Transcriptional regulation exhibits extensive robustness, but human genetics indicates sensitivity to transcription factor (TF) dosage. Reconciling...
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Excipients for Novel Inhaled Dosage Forms: An Overview
Pulmonary drug delivery is a form of local targeting to the lungs in patients with respiratory disorders like cystic fibrosis, pulmonary arterial...
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Sensitivity to gene dosage and gene expression affects genes with copy number variants observed among neuropsychiatric diseases
BackgroundCopy number variants (CNVs) have been reported to be associated with diseases, traits, and evolution. However, it is hard to determine...
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Molecular mechanisms of sensitivity and resistance to radiotherapy
The molecular mechanisms underlying sensitivity and resistance to radiotherapy is an area of active investigation and discovery as its clinical...
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ZIF-8 Nanoparticle: A Valuable Tool for Improving Gene Delivery in Sperm-Mediated Gene Transfer
Metal–organic frameworks (MOFs) are porous materials with unique characteristics that make them well-suited for drug delivery and gene therapy...
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Noninvasive prenatal diagnosis of duchenne muscular dystrophy in five Chinese families based on relative mutation dosage approach
BackgroundRelative haplotype dosage (RHDO) approach has been applied in noninvasive prenatal diagnosis (NIPD) of Duchenne muscular dystrophy (DMD)....
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Study on the association between adverse drug reactions to opioids and gene polymorphisms: a case-case–control study
ObjectiveAdverse drug reactions (ADRs) caused by opioid drugs show individual differences. Our objective was to explore the association between gene...
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Pharmaceutical application and development of fixed-dose combination: dosage form review
BackgroundFixed dose combination (FDC) products are common in the treatment of various disease such as hypertension, diabetes, HIV and HCV, Pain,...
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PDZK1 confers sensitivity to sunitinib in clear cell renal cell carcinoma by suppressing the PDGFR-β pathway
BackgroundSunitinib has emerged as the primary treatment for advanced or metastatic clear cell renal cell carcinoma (ccRCC) due to its significant...
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Recent Advances on Therapeutic Approaches for Friedreich’s Ataxia: New Pharmacological Targets, Protein, and Gene Therapy
Friedreich ataxia (FA) is an inherited autosomal recessive neurodegenerative disorder. The most common mutation in FA is caused by a (GAA)n triplet...
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A software tool to adjust codeine dose based on CYP2D6 gene-pair polymorphisms and drug-drug interactions
Codeine is metabolized by the CYP2D6 enzyme, and individuals with certain genetic variations of the CYP2D6 gene may metabolize codeine differently,...
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Long-term effects of a fat-directed FGF21 gene therapy in aged female mice
Fibroblast growth factor 21 (FGF21) has been developed as a potential therapeutic agent for metabolic syndromes. Moreover, FGF21 is considered a...
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Pharmacological evaluation of vitamin D in COVID-19 and long COVID-19: recent studies confirm clinical validation and highlight metformin to improve VDR sensitivity and efficacy
Nearly four years after its first appearance, and having gone from pandemic to endemic, the SARS-CoV-2 remains out of control globally. The purpose...
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Gene therapy for CNS disorders: modalities, delivery and translational challenges
Gene therapy is emerging as a powerful tool to modulate abnormal gene expression, a hallmark of most CNS disorders. The transformative potentials of...
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Heightened sensitivity to high-calorie foods in children at risk for obesity: insights from behavior, neuroimaging, and genetics
Pediatric obesity is a major public health concern. Genetic susceptibility and increased availability of energy-dense food are known risk factors for...
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Auranofin repurposing for lung and pancreatic cancer: low CA12 expression as a marker of sensitivity in patient-derived organoids, with potentiated efficacy by AKT inhibition
BackgroundThis study explores the repurposing of Auranofin (AF), an anti-rheumatic drug, for treating non-small cell lung cancer (NSCLC)...
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Modeling gene × environment interactions in PTSD using human neurons reveals diagnosis-specific glucocorticoid-induced gene expression
Post-traumatic stress disorder (PTSD) can develop following severe trauma, but the extent to which genetic and environmental risk factors contribute...
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X, but not Y, Chromosomal Complement Contributes to Stroke Sensitivity in Aged Animals
Post-menopausal women become vulnerable to stroke and have poorer outcomes and higher mortality than age-matched men, and previous studies suggested...
