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LINE-1 transcription activates long-range gene expression
Long interspersed nuclear element-1 (LINE-1 or L1) is a retrotransposon group that constitutes 17% of the human genome and shows variable expression...
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Excitation–transcription coupling, neuronal gene expression and synaptic plasticity
Excitation–transcription coupling (E–TC) links synaptic and cellular activity to nuclear gene transcription. It is generally accepted that E–TC makes...
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Enhancer–promoter specificity in gene transcription: molecular mechanisms and disease associations
Although often located at a distance from their target gene promoters, enhancers are the primary genomic determinants of temporal and spatial...
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Genetic architecture and correlations between the gut microbiome and gut gene transcription in Chinook salmon (Oncorhynchus tshawytscha)
Population divergence through selection can drive local adaptation in natural populations which has implications for the effective restoration of...
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RGS1 Enhancer RNA Promotes Gene Transcription by Recruiting Transcription Factor FOXJ3 and Facilitates Osteoclastogenesis Through PLC-IP3R-dependent Ca2+ Response in Rheumatoid Arthritis
Recent evidence has highlighted the functions of enhancers in modulating transcriptional machinery and affecting the development of human diseases...
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Transcription Factors and Signal Transduction
In this chapter, we will present transcription factors as the key controllers of gene expression. The activities of these proteins critically...
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Identification of miRNA-Target Gene-Transcription Factor Regulatory Network as Functional Motifs Involved in Glomerular Diabetic Nephropathy
AbstractThe gene regulatory approach based on retrieving information from the database provides a detailed characterization of the molecular...
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Transcription
Transcription plays an essential role in producing protein-coding messenger RNAs (mRNAs) and also other noncoding RNAs essential for proper cell...
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Resetting var Gene Transcription in Plasmodium falciparum
One of the key mechanisms contributing to the virulence of Plasmodium falciparum is its ability to undergo antigenic switching among antigenically...
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Nescient helix-loop-helix 1 (Nhlh1) is a novel activating transcription factor 5 (ATF5) target gene in olfactory and vomeronasal sensory neurons in mice
Activating transcription factor 5 (ATF5) is a transcription factor that belongs to the cAMP-response element-binding protein/ATF family and is...
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Cardiac Transcription Factors and Regulatory Networks
Cardiac development is a fine-tuned process governed by complex transcriptional networks, in which transcription factors (TFs) interact with other...
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Gene Expression and Chromatin
In this chapter, principles of gene expression are discussed. An essential condition that a gene can be expressed, i.e., transcribed into RNA, is...
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Reverse Transcription-Quantitative Real-Time Polymerase Chain Reaction (RT-qPCR) for Gene Expression Analyses
The reverse transcription-quantitative real-time polymerase chain reaction (RT-qPCR) is considered to be the gold standard for gene expression...
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Downregulation of NUP93 aggravates hypoxia-induced death of cardiomyocytes in vitro through abnormal regulation of gene transcription
Nuclear pore complex in the nuclear envelope plays an important role in controlling the transportation of RNAs, proteins and other macromolecules...
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A Key Transcription Factor Family: Nuclear Receptors
In this chapter, a highly interesting family of ligand-inducible transcription factors, referred to as nuclear receptors, will be presented. Nuclear...
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Circadian gene ARNTL initiates circGUCY1A2 transcription to suppress non-small cell lung cancer progression via miR-200c-3p/PTEN signaling
BackgroundAs a subclass of endogenous stable noncoding RNAs, circular RNAs are beginning to be appreciated for their potential as tumor therapeutics....
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Nanodelivery in Gene Therapy
Gene therapy stands as a revolutionary approach in medicine, aiming to rectify genetic abnormalities by introducing therapeutic genes or regulating...
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Analysis of var Gene Transcription Pattern Using DBLα Tags
The Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) antigens, which are encoded by a multigene family called var genes, are exported...
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The Gene Rearrangement and Transcriptional Regulation of Non B Cell-Derived Immunoglobulin
Traditionally, immunoglobulin (Ig) expression has been attributed solely to B cells/plasma cells with well-documented and accepted regulatory...