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Robust machine−learning based prognostic index using cytotoxic T lymphocyte evasion genes highlights potential therapeutic targets in colorectal cancer
BackgroundA minute fraction of patients stands to derive substantial benefits from immunotherapy, primarily attributable to immune evasion. Our...
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Lipolytic inhibitor G0S2 modulates glioma stem-like cell radiation response
BackgroundIonizing radiation (IR) therapy is the standard first-line treatment for newly diagnosed patients with glioblastoma (GBM), the most common...
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Targeting copper death genoty** associated gene RARRES2 suppresses glioblastoma progression and macrophages infiltration
BackgroundCopper homeostasis is associated with malignant biological behavior in various tumors. The excessive accumulation of copper can induce...
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Transcriptional analysis of the expression and prognostic value of lipid droplet-localized proteins in hepatocellular carcinoma
The accumulation of lipid droplets (LDs) in hepatocytes is the main pathogenesis in nonalcoholic fatty liver disease (NAFLD), which is also the key...
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Correction to: Lipolytic inhibitor G0S2 modulates glioma stem-like cell radiation response
In the original publication of this article [1], the Gene Expression Omnibus (GEO) accession code GSE79772 is wrong. The correct accession code...
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Single-cell characterisation of tissue homing CD4 + and CD8 + T cell clones in immune-mediated refractory arthritis
BackgroundImmune-mediated arthritis is a group of autoinflammatory diseases, where the patient’s own immune system attacks and destroys synovial...
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BETi enhance ATGL expression and its lipase activity to exert their antitumoral effects in triple-negative breast cancer (TNBC) cells
BackgroundTriple-Negative Breast Cancer (TNBC) is a subtype of breast cancer that differs from other types of breast cancers in the faster spread and...
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An integrated view of lipid metabolism in ferroptosis revisited via lipidomic analysis
Ferroptosis is a form of regulated cell death characterized by iron-dependent lipid peroxidation. This process contributes to cellular and tissue...
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An epigenome-wide association study of posttraumatic stress disorder in US veterans implicates several new DNA methylation loci
BackgroundPrevious studies using candidate gene and genome-wide approaches have identified epigenetic changes in DNA methylation (DNAm) associated...
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Exploring the Pattern of Metabolic Alterations Causing Energy Imbalance via PPARα Dysregulation in Cardiac Muscle During Doxorubicin Treatment
Cardiotoxicity by anthracycline antineoplastic drug doxorubicin is one of the systemic toxicity of the cardiovascular system. The mechanism...
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Adipose Tissue Lipid Metabolism During Exercise
Adipose tissue-derived fatty acids are the primary source of energy during low-intensity exercise. Although the relative contribution of fat to...
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Genome-wide DNA methylation status of Mongolians exhibits signs of cellular stress response related to their nomadic lifestyle
BackgroundEpigenetics is crucial for connecting environmental stresses with physiological responses in humans. Mongolia, where nomadic livestock...
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Identification of Key Genes and Potential Pathways Associated with Mastitis Induced by E. coli
Mastitis is one of the most important diseases of dairy cattle. It is an infectious disease leading to an inflammatory reaction in the cow's mammary...
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Polydactyly-derived allogeneic chondrocyte cell-sheet transplantation with high tibial osteotomy as regenerative therapy for knee osteoarthritis
Allogeneic cell therapies are not fully effective in treating osteoarthritis of the knee (OAK). We recently reported that transplantation of...
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A novel variant in SMG9 causes intellectual disability, confirming a role for nonsense-mediated decay components in neurocognitive development
Biallelic loss-of-function variants in the SMG9 gene, encoding a regulatory subunit of the mRNA nonsense-mediated decay (NMD) machinery, are reported...
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Identifying drivers of breast cancer metastasis in progressively invasive subpopulations of zebrafish-xenografted MDA-MB-231
Cancer metastasis is the primary cause of the high mortality rate among human cancers. Efforts to identify therapeutic agents targeting cancer...
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CGI-58: Versatile Regulator of Intracellular Lipid Droplet Homeostasis
Comparative gene identification-58 (CGI-58), also known as α/β-hydrolase domain-containing 5 (ABHD5), is a member of a large family of proteins...
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Single-cell transcriptomics of the ventral posterolateral nucleus-enriched thalamic regions from HSV-1-infected mice reveal a novel microglia/microglia-like transcriptional response
BackgroundMicroglia participate in the immune response upon central nervous system (CNS) infections. However, the role of these cells during herpes...
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Lipid metabolism and its implications in tumor cell plasticity and drug resistance: what we learned thus far?
Metabolic reprogramming, a hallmark of cancer, allows cancer cells to adapt to their specific energy needs. The Warburg effect benefits cancer cells...
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Advances in translational research of the rare cancer type adrenocortical carcinoma
Adrenocortical carcinoma is a rare malignancy with an annual worldwide incidence of 1–2 cases per 1 million and a 5-year survival rate of <60%....
