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Modeling of Transmembrane Domain and Full-Length TLRs in Membrane Models
Toll-like receptors (TLRs), classified as pattern recognition receptors, have a primordial role in the activation of the innate immunityInnate...
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Full-length genome characterization of a novel mitovirus isolated from the root rot fungus Armillaria mellea
Members of the genus Armillaria belong to the group of pathogenic and facultative saprotrophic fungi that are generally known as one of the causative...
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Bioinformatical View on the Contribution of MAST/IRE-Dependent Phosphorylation in the Tubulin Code
AbstractProtein kinases represent one of the largest eukaryotic enzyme superfamilies. However, only a few can directly phosphorylate tubulin and...
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Thymidine nucleotide metabolism controls human telomere length
Telomere length in humans is associated with lifespan and severe diseases, yet the genetic determinants of telomere length remain incompletely...
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Impact of suspected adverse drug reactions on mortality and length of hospital stay in the hospitalised patients: a meta-analysis
PurposeTo estimate the risk of mortality and length of stay in hospitalised patients who have experienced suspected adverse drug reactions (ADRs) as...
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Intravital measurements of solid stresses in tumours reveal length-scale and microenvironmentally dependent force transmission
In cancer, solid stresses impede the delivery of therapeutics to tumours and the trafficking and tumour infiltration of immune cells. Understanding...
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Full genome sequence of a novel iflavirus from the aster leafhopper Macrosteles fascifrons
The aster leafhopper Macrosteles fascifrons is a common insect pest that feeds on rice and other plants and may serve as a vector to transmit various...
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Phylogenetic relationship of Prohemistomum vivax to other trematodes based on the internal transcribed spacer region and mitochondrial genes
Prohemistomum vivax is a zoonotic small cyathocotylid trematode that inhabits the intestines of fish-eating birds and mammals. Here, we amplified the...
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Full-length genome sequences of the first H9N2 avian influenza viruses isolated in the Northeast of Algeria
BackgroundH9N2 avian influenza viruses (AIV) has a worldwide geographic distribution and affects poultry of different types of production. H9N2 AIV...
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Full Wave Inversion and Inverse Scattering in Ultrasound Tomography/Volography
Ultrasound breast tomography has been around for more than 40 years. Early approaches to reconstruction focused on simple algebraic reconstructions...
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Full protection from SARS-CoV-2 brain infection and damage in susceptible transgenic mice conferred by MVA-CoV2-S vaccine candidate
Vaccines against SARS-CoV-2 have been shown to be safe and effective but their protective efficacy against infection in the brain is yet unclear....
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Mu Opioids Induce Biased Signaling at the Full-Length Seven Transmembrane C-Terminal Splice Variants of the mu Opioid Receptor Gene, Oprm1
The biased signaling has been extensively studied in the original mu opioid receptor (MOR-1), particularly through G protein and β-arrestin2...
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Region Capture Micro-C reveals coalescence of enhancers and promoters into nested microcompartments
Although enhancers are central regulators of mammalian gene expression, the mechanisms underlying enhancer–promoter (E-P) interactions remain...
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Brain matters: unveiling the distinct contributions of region, age, and sex to glia diversity and CNS function
The myelinated white matter tracts of the central nervous system (CNS) are essential for fast transmission of electrical impulses and are often...
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The antigen recognition portion of African buffalo class I MHC is highly polymorphic, consistent with a complex pathogen challenge environment, and the 3’ region suggests distinct haplotype configurations
African buffalo ( Syncerus caffer) have been distinct from the Auroch lineage leading to domestic cattle for 5 million years, and are reservoirs of...
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Reprogramming the genetic code
The encoded biosynthesis of proteins provides the ultimate paradigm for high-fidelity synthesis of long polymers of defined sequence and composition,...
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Inferences on a multidimensional social hierarchy use a grid-like code
Generalizing experiences to guide decision-making in novel situations is a hallmark of flexible behavior. Cognitive maps of an environment or task...
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Interferons and viruses induce a novel truncated ACE2 isoform and not the full-length SARS-CoV-2 receptor
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which causes COVID-19, utilizes angiotensin-converting enzyme 2 (ACE2) for entry into...
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Long-read RNA sequencing identifies region- and sex-specific C57BL/6J mouse brain mRNA isoform expression and usage
Alternative splicing (AS) contributes to the biological heterogeneity between species, sexes, tissues, and cell types. Many diseases are either...
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Polygenic basis and biomedical consequences of telomere length variation
Telomeres, the end fragments of chromosomes, play key roles in cellular proliferation and senescence. Here we characterize the genetic architecture...
