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Association between lipid-A-producing oral bacteria of different potency and fractional exhaled nitric oxide in a Norwegian population-based adult cohort
BackgroundLipid A is the primary immunostimulatory part of the lipopolysaccharide (LPS) molecule. The inflammatory response of LPS varies and depends...
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Nitric Oxide as a Diagnostic and Therapeutic Tool in Respiratory Diseases
Nitric oxide (NO) is a gasotransmitter that plays a vital role in diverse biological processes. NO is a fundamental component in regulating...
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Nitric oxide in occurrence, progress and therapy of lung Cancer: a systemic review and meta-analysis
BackgroundNitric oxide (NO) plays an important role in lung cancer. However, the results of previous studies about NO in the occurrence, progress and...
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Increased expression of IL1-RL1 is associated with type 2 and type 1 immune pathways in asthma
BackgroundAsthma is a common chronic airway disease in the world. The purpose of this study was to explore the expression of IL1-RL1 in sputum and...
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A single dose of angiotensin-(1–7) resolves eosinophilic inflammation and protects the lungs from a secondary inflammatory challenge
ObjectiveAngiotensin-(1–7) [Ang-(1–7)] is a pro-resolving mediator. It is not known whether the pro-resolving effects of Ang-(1–7) are sustained and...
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The upregulation of peripheral CD3-CD56+CD16+ natural killer cells correlates with Th1/Th2 imbalance in asthma patients during acute upper respiratory viral infections
PurposeThe aim of this study is to clarify the changes of peripheral CD3 − CD56 + CD16 + NK cells and their correlation with Th1/Th2 immunity profiles in...
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Smelling the Disease: Diagnostic Potential of Breath Analysis
Breath analysis is a relatively recent field of research with much promise in scientific and clinical studies. Breath contains endogenously produced...
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Effects of 7-day polyphenol powder supplementation on cycling performance and lung function in an ozone-polluted environment
PurposePolluted environments can adversely affect lung function and exercise performance. Evidence suggests that some nutrient supplements may offset...
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Concentration-dependent increase in symptoms due to diesel exhaust in a controlled human exposure study
BackgroundTraffic-related air pollution (TRAP) exposure causes adverse effects on wellbeing and quality of life, which can be studied non-invasively...
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Precision Medicine in Asthma Therapy
Asthma is a complex, heterogeneous disease that necessitates a proper patient evaluation to decide the correct treatment and optimize disease...
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Is a 12-h Nitrox dive hazardous for pulmonary function?
PurposeProlonged exposure to a high partial pressure of oxygen leads to inflammation of pulmonary tissue [pulmonary oxygen toxicity (POT)], which is...
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Controlled human exposure to diesel exhaust: results illuminate health effects of traffic-related air pollution and inform future directions
Air pollution is an issue of increasing interest due to its globally relevant impacts on morbidity and mortality. Controlled human exposure (CHE)...
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Health effects after inhalation of micro- and nano-sized zinc oxide particles in human volunteers
Inhalation of ZnO particles can cause inflammation of the airways and metal fume fever. It is unclear if different sizes of the particles alter these...
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A Current Perspective of Allergic Asthma: From Mechanisms to Management
Asthma is a result of heterogenous, complex gene–environment interactions with variable clinical phenotypes, inflammation, and remodeling. It affects...
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Acute cardiovascular effects of controlled exposure to dilute Petrodiesel and biodiesel exhaust in healthy volunteers: a crossover study
BackgroundAir pollution derived from combustion is associated with considerable cardiorespiratory morbidity and mortality in addition to...
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Pulmonary Delivery of Antibody for the Treatment of Respiratory Diseases
Over the past 30 years, therapeutic antibodies (Abs) have offered ground-breaking solutions for a wide range of diseases, including respiratory...
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Chronic Obstructive Pulmonary Disease (COPD)
Effective COPD diagnosis and disease stratification is largely hindered due to presence of symptomatic similarity with other lung diseases and...
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Group 2 innate lymphoid cells and their surrounding environment
Since the discovery of group 2 innate lymphoid cells (ILC2s) in 2010, subsequent studies have revealed their developmental pathways, mechanisms of...
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Exposure limits for indoor volatile substances concerning the general population: The role of population-based differences in sensory irritation of the eyes and airways for assessment factors
Assessment factors (AFs) are essential in the derivation of occupational exposure limits (OELs) and indoor air quality guidelines. The factors shall...
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Targeting Molecular and Cellular Mechanisms in Asthma
Many a times, a very thin line exists between physiology and pathology. Airway obstruction seen in the asthmatic subjects is exemplary of such...