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Incorporating knowledge of disease-defining hub genes and regulatory network into a machine learning-based model for predicting treatment response in lupus nephritis after the first renal flare
BackgroundIdentifying candidates responsive to treatment is important in lupus nephritis (LN) at the renal flare (RF) because an effective treatment...
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Vaccines prevent reinduction of rheumatoid arthritis symptoms in collagen-induced arthritis mouse model
Metabolic reprogramming of immune cells modulates their function and reduces the severity of autoimmune diseases. However, the long-term effects of...
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Miniaturized implantable temperature sensors for the long-term monitoring of chronic intestinal inflammation
Diagnosing and monitoring inflammatory bowel diseases, such as Crohn’s disease, involves the use of endoscopic imaging, biopsies and serology. These...
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Garetosmab in fibrodysplasia ossificans progressiva: a randomized, double-blind, placebo-controlled phase 2 trial
Fibrodysplasia ossificans progressiva (FOP) is a rare disease characterized by heterotopic ossification (HO) in connective tissues and painful...
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Insilico Screening of Pentacyclic Triterpenoids against Vascular Dementia Target’s
Vascular dementia (VaD) accounts to 30% of cases and is predicted as second most common form of dementia after Alzheimer’s disease by WHO. Earlier...
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Genomic predictors of response to PD-1 inhibition in children with germline DNA replication repair deficiency
Cancers arising from germline DNA mismatch repair deficiency or polymerase proofreading deficiency (MMRD and PPD) in children harbour the highest...
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FLASH radiotherapy for the treatment of symptomatic bone metastases in the thorax (FAST-02): protocol for a prospective study of a novel radiotherapy approach
BackgroundFLASH therapy is a treatment technique in which radiation is delivered at ultra-high dose rates (
≥ 40 Gy/s). The first-in-human FAST-01... -
Analysis of transcriptomic features reveals molecular endotypes of SLE with clinical implications
BackgroundSystemic lupus erythematosus (SLE) is known to be clinically heterogeneous. Previous efforts to characterize subsets of SLE patients based...
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Opioid toxicity: histamine, hypersensitivity, and MRGPRX2
Insights into the pathophysiology of many non-immune-mediated drug reactions referred to as toxicities, sensitivities, intolerances, or...
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Progressive multifocal leukoencephalopathy, advanced ductal breast carcinoma, systemic sclerosis, and checkpoint inhibitors: a therapeutic dilemma
Progressive multifocal leukoencephalopathy (PML) is a demyelinating central nervous system disease infection by JC virus (JCV) in patients with a...
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Quantification of bone flare on 18F-NaF PET/CT in metastatic castration-resistant prostate cancer
BackgroundBone flare has been observed on 99m Tc-MDP bone scans of patients with metastatic castration-resistant prostate cancer (mCRPC). This...
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Sarcoptes scabiei infestation in a captive lowland tapir (Tapirus terrestris): case report, morphological and molecular genetic mite identification
Sarcoptes scabiei (Acari: Sarcoptidae) is a globally distributed parasitic mite species, which causes mange in a broad spectrum of domestic and wild...
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Inactivation of the gene encoding procalcitonin prevents antibody-mediated arthritis
BackgroundProcalcitonin (PCT) is applied as a sensitive biomarker to exclude bacterial infections in patients with rheumatoid arthritis (RA)...
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Tolerability and tropism of recombinant adeno-associated virus vectors in the African green monkey (Chlorocebus sabaeus) anterior chamber
While many studies have investigated the use of recombinant adeno-associated vectors (rAAV) in the posterior chamber for treatment of inherited...
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Upregulation of CD39 During Gout Attacks Promotes Spontaneous Remission of Acute Gouty Inflammation
Gout is a self-limiting form of inflammatory arthropathy caused by the formation of urate crystals due to hyperuricemia. The resolution of gout...
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Liposomal drug delivery system for anti-inflammatory treatment after cataract surgery: a phase I/II clinical trial
Liposomes as a drug delivery system may overcome the problems associated with non-compliance to eyedrops and inadequate control of inflammation after...
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Immunomodulating effects of the single bacterial strain therapy EDP1815 on innate and adaptive immune challenge responses — a randomized, placebo-controlled clinical trial
The gut microbiome can modulate systemic inflammation and is therefore target for immunomodulation. Immunomodulating effects of EDP1815, a bacterial...
