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Pirfenidone affects human cardiac fibroblast proliferation and cell cycle activity in 2D cultures and engineered connective tissues
The anti-fibrotic drug pirfenidone (PFD) is currently in clinical testing for the treatment of heart failure with preserved ejection fraction;...
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Fibroblast-Conditioned Media Enhance the Yield of Microglia Isolated from Mixed Glial Cultures
Microglia are the main immune cells of the central nervous system (CNS) and comprise various model systems used to investigate inflammatory...
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Assessment of the Direct Action of Dynamic Electroneurostimulation on in Vitro Dermal Fibroblast Culture
In vitro studies using state-of-the-art research techniques demonstrated and explained the direct action of dynamic electroneurostimulation on...
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Angiogenin as a Possible Mediator of Macrophage-Mediated Regulation of Fibroblast Functions
We studied angiogenin production by human macrophages and evaluated the role of this factor in the macrophage-mediated regulation of fibroblasts. All...
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Transcription factors in fibroblast plasticity and CAF heterogeneity
In recent years, research focused on the multifaceted landscape and functions of cancer-associated fibroblasts (CAFs) aimed to reveal their...
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EGR1 Mediated Reduction of Fibroblast Secreted-TGF-β1 Exacerbated CD8+ T Cell Inflammation and Migration in Vitiligo
Vitiligo is a T cell-mediated depigment skin disease caused by the complex interplay between melanocyte dysfunction, environmental stimulation, and...
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Fibroblast subtypes in pancreatic cancer and pancreatitis: from mechanisms to therapeutic strategies
Excessive fibrosis is a predominant feature of pancreatic stroma and plays a crucial role in the development and progression of pancreatic ductal...
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Evidence of steady-state fibroblast subtypes in the normal human breast as cells-of-origin for perturbed-state fibroblasts in breast cancer
BackgroundHuman breast cancer most frequently originates within a well-defined anatomical structure referred to as the terminal duct lobular unit...
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Targeting glycolytic pathway in fibroblast-like synoviocytes for rheumatoid arthritis therapy: challenges and opportunities
IntroductionRheumatoid arthritis (RA) is a chronic autoimmune disorder characterized by hyperplastic synovium, pannus formation, immune cell...
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Cancer-associated fibroblast-secreted FGF7 as an ovarian cancer progression promoter
BackgroundOvarian cancer (OC) is distinguished by its aggressive nature and the limited efficacy of current treatment strategies. Recent studies have...
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Lymphatic cells do not functionally integrate into 3D organotypic brain slice cultures, but aggregate around penetrating blood vessels
Brain slice culture (BSC) is a well-known three-dimensional model of the brain. In this study, we use organotypic slices for studying neuro-lymphatic...
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Features of Intracellular Signal Transduction in Neural Stem Cells under the Influence of Alkaloid Songorine, an Agonist of Fibroblast Growth Factor Receptors
We performed a comparative in vitro study of the involvement of NF-κB, PI3K, cAMP, ERK1/2, p38, JAKs, STAT3, JNK, and p53-dependent intracellular...
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Neuroregenerative “Bystander”-Effects of Conditioned Media from Adipose Tissue-Derived Fibroblast-Like Cells in Vitro
A promising direction in the development of new technologies for the treatment of the central nervous system diseases is the use of different types...
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Imatinib inhibits pericyte-fibroblast transition and inflammation and promotes axon regeneration by blocking the PDGF-BB/PDGFRβ pathway in spinal cord injury
BackgroundFibrotic scar formation and inflammation are characteristic pathologies of spinal cord injury (SCI) in the injured core, which has been...
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Epidermal–dermal coupled spheroids are important for tissue pattern regeneration in reconstituted skin explant cultures
Tissue patterning is critical for the development and regeneration of organs. To advance the use of engineered reconstituted skin organs, we study...
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Alamandine/MrgD axis prevents TGF-β1-mediated fibroblast activation via regulation of aerobic glycolysis and mitophagy
BackgroundIdiopathic pulmonary fibrosis is a chronic progressive, lethal disease in which ectopic lung fibroblast (LF) activation plays a vital part....
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Proteomic characterisation of prostate cancer intercellular communication reveals cell type-selective signalling and TMSB4X-dependent fibroblast reprogramming
BackgroundIn prostate cancer, the tumour microenvironment (TME) represents an important regulator of disease progression and response to treatment....
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Fibroblast growth factor 2 reduces endoplasmic reticulum stress and apoptosis in in-vitro Non-Alcoholic Fatty Liver Disease model
PurposeNon-Alcoholic fatty liver disease is characterized by the accumulation of excess fat in the liver, chronic inflammation, and cell death,...
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Cell Cultures at the Air–Liquid Interface and Their Application in Cancer Research
Air-liquid interface (ALI) cell cultures are considered a valid tool for the replacement of animals in biomedical research. By mimicking crucial...
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Helicobacter pylori-induced fibroblast-derived Serpin E1 promotes gastric cancer growth and peritoneal dissemination through p38 MAPK/VEGFA-mediated angiogenesis
BackgroundFibroblasts, especially cancer-associated fibroblasts (CAFs), represent the predominant stromal cell population in the tumor...
