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Familial and hereditary pancreatic cancer in Japan
As in Western countries, familial pancreatic cancer accounts for 5–7% of pancreatic cancer (PC) in Japan. Opportunities for diagnosing hereditary...
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The Spanish Familial Pancreatic Cancer Registry (PANGENFAM): a decade follow-up of individuals at high-risk for pancreatic cancer
The Spanish Familial Pancreatic Cancer Registry (PANGENFAM) was established in 2009 and aims to characterize the genotype and phenotype of familial...
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Precursor lesions in familial and hereditary pancreatic cancer
Infiltrating ductal adenocarcinoma of the pancreas, referred to here as “pancreatic cancer,” is one of the deadliest of all of the solid...
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Familial pancreatic cancer: a long fruitful journey
In the early years of my GI fellowship, a healthy 40-year-old man came to my clinic and announced that he was going to die of pancreatic cancer. His...
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Two Japanese families with familial pancreatic cancer with suspected pathogenic variants of CDKN2A: a case report
BackgroundGermline mutations in CDKN2A result in Familial Atypical Multiple Mole Melanoma Syndrome (FAMMM) (OMIM #155,601), which is associated with...
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Characteristics of familial pancreatic cancer families with additional colorectal carcinoma
Familial pancreatic cancer (FPC) is a rare hereditary tumor entity with broad phenotypic heterogeneity, including colorectal carcinoma (CRC) in some...
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Familial pancreatic cancer: a case study and review of the psychosocial effects of diagnoses on families
BackgroundFamilial pancreatic cancer touches families through a genetic susceptibility to develo** this neoplasia. Genetic susceptibility is...
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Twenty-five years of surveillance for familial and hereditary pancreatic ductal adenocarcinoma: Historical perspectives and introduction to the special issue
In the 1990s, as prevention became a central strategy in the battle against cancer and the molecular genetics revolution uncovered the genetic basis...
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Understanding familial risk of pancreatic ductal adenocarcinoma
Pancreatic ductal adenocarcinoma (PDAC) is a deadly disease that is the result of an accumulation of sequential genetic alterations. These genetic...
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The Italian registry of families at risk for pancreatic cancer (IRFARPC): implementation and evolution of a national program for pancreatic cancer surveillance in high-risk individuals
Screening programs for early detection and treatment of pancreatic cancer (PC) and its precursor lesions are increasingly implemented worldwide to...
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Surgical aspects related to hereditary pancreatic cancer
The goal of surveillance programs for individuals at risk (IAR) from familial pancreatic cancer (FPC) families or families with other inherited tumor...
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Integrated In Silico Analysis of Proteogenomic and Drug Targets for Pancreatic Cancer Survival
Pancreatic cancer remains a major health concern, being among the deadliest forms of cancer with over 80% of the patients presenting with metastatic...
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Current status of inherited pancreatic cancer
BackgroundIt is estimated that about 10% of pancreatic cancer cases have a genetic background. People with a familial predisposition to pancreatic...
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Identification of RAD17 as a candidate cancer predisposition gene in families with histories of pancreatic and breast cancers
BackgroundAmong the 10% of pancreatic cancers that occur in a familial context, around a third carry a pathogenic variant in a cancer predisposition...
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The role of biomarkers in the early detection of pancreatic cancer
Pancreatic surveillance can detect early-stage pancreatic cancer and achieve long-term survival, but currently involves annual endoscopic ultrasound...
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Human Microbiome Modulation: A Potential Therapeutic Strategy for Pancreatic Cancer
Pancreatic cancer is a disorder that affects the biochemical and metabolic physiology of pancreas. It is the most intractable and lethal of all GI...
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Review of the cost-effectiveness of surveillance for hereditary pancreatic cancer
Individuals with hereditary pancreatic cancer risk include high risk individuals (HRIs) with germline genetic susceptibility to pancreatic cancer...
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Aspects and outcomes of surveillance for individuals at high-risk of pancreatic cancer
Pancreatic ductal adenocarcinoma (PDAC) is a leading cause of cancer-related deaths and is associated with a poor prognosis. The majority of these...
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Pancreatic cancer in Saudi Arabia (2005–2020): increasing trend
Pancreatic cancer, a highly fatal malignancy, has shown a global rise in the incidence and mortality rates. However, these rates vary significantly...
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Expanding access to genetic testing for pancreatic cancer
Among individuals with pancreatic ductal adenocarcinoma (PDAC) 5–10% have a pathogenic germline variant (PGV) in a PDAC susceptibility gene....
