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FBXO38 regulates macrophage polarization to control the development of cancer and colitis
Macrophages are highly plastic cells that differentially regulate multiple pathological conditions, including cancer and autoimmune diseases. In...
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A novel homozygous FBXO38 variant causes an early-onset distal hereditary motor neuronopathy type IID
Distal hereditary motor neuronopathies (dHMN) are a genetically heterogeneous group of neuromuscular disorders caused by anterior horn cell...
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E3 ubiquitin ligases in cancer stem cells: key regulators of cancer hallmarks and novel therapeutic opportunities
BackgroundHuman malignancies are composed of heterogeneous subpopulations of cancer cells with phenotypic and functional diversity. Among them, a...
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Comprehensive assessment of TECENTRIQ® and OPDIVO®: analyzing immunotherapy indications withdrawn in triple-negative breast cancer and hepatocellular carcinoma
Atezolizumab (TECENTRIQ®) and nivolumab (OPDIVO®) are both immunotherapeutic indications targeting programmed cell death 1 ligand 1 (PD-L1) and...
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FBXO32 targets PHPT1 for ubiquitination to regulate the growth of EGFR mutant lung cancer
BackgroundPhosphohistidine phosphatase 1 (PHPT1) is an oncogene that has been reported to participate in multiple tumorigenic processes. As yet,...
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E3 ubiquitin ligases: styles, structures and functions
E3 ubiquitin ligases are a large family of enzymes that join in a three-enzyme ubiquitination cascade together with ubiquitin activating enzyme E1...
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Buffy coat signatures of breast cancer risk in a prospective cohort study
BackgroundEpigenetic alterations are a near-universal feature of human malignancy and have been detected in malignant cells as well as in easily...
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Insights from a 30-year journey: function, regulation and therapeutic modulation of PD1
PD1 was originally discovered in 1992 as a molecule associated with activation-induced cell death in T cells. Over the past 30 years, it was found...
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Regulation of Cancer Immune Checkpoint: Mono- and Poly-Ubiquitination: Tags for Fate
The antagonism, stalemate and compromise between the immune system and tumor cells is closely associated with tumor development and progression. In...
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Knockout Mouse Models Provide Insight into the Biological Functions of CRL1 Components
The CRL1 complex, also known as the SCF complex, is a ubiquitin ligase that in mammals consists of an adaptor protein (SKP1), a scaffold protein...
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Deciphering colorectal cancer genetics through multi-omic analysis of 100,204 cases and 154,587 controls of European and east Asian ancestries
Colorectal cancer (CRC) is a leading cause of mortality worldwide. We conducted a genome-wide association study meta-analysis of 100,204 CRC cases...
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N6-methyladenosine-modified circIGF2BP3 inhibits CD8+ T-cell responses to facilitate tumor immune evasion by promoting the deubiquitination of PD-L1 in non-small cell lung cancer
BackgroundAn in-depth understanding of immune evasion mechanisms in tumors is crucial to overcome resistance and enable innovative advances in...
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Regulation of Par-4 by Ubiquitinases
The ubiquitin-proteasome system (UPS) is a complex cellular machine that is responsible for maintaining normal homeostasis by targeting misfolded and...
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Lipid Metabolism and Immune Checkpoints
Immune checkpoints are essential for the regulation of immune cell functions. Although the abrogation of immunosurveillance of tumor cells is known,...
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Assessing non-Mendelian inheritance in inherited axonopathies
PurposeInherited axonopathies (IA) are rare, clinically and genetically heterogeneous diseases that lead to length-dependent degeneration of the long...
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Roles of PD-1/PD-L1 Pathway: Signaling, Cancer, and Beyond
Immunotherapies that target PD-1/PD-L1 axis have shown unprecedented success in a wide variety of human cancers. PD-1 is one of the key coinhibitory...
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Development of somatic mutation signatures for risk stratification and prognosis in lung and colorectal adenocarcinomas
BackgroundPrognostic signatures are vital to precision medicine. However, development of somatic mutation prognostic signatures for cancers remains a...
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Deep sequencing reveals variations in somatic cell mosaic mutations between monozygotic twins with discordant psychiatric disease
Monozygotic (MZ) twins have been thought to be genetically identical. However, recent studies have shown discordant variants between them. We...
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Microglia lacking a peroxisomal β-oxidation enzyme chronically alter their inflammatory profile without evoking neuronal and behavioral deficits
BackgroundMicroglia play a central role in most neurological disorders, but the impact of microgliosis on brain environment and clinical functions is...
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Tim-3 signaling blockade with α-lactose induces compensatory TIGIT expression in Plasmodium berghei ANKA-infected mice
BackgroundMalaria, one of the largest health burdens worldwide, is caused by Plasmodium spp. infection. Upon infection, the host’s immune system...
