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Sex differences in pre- and post-synaptic glutamate signaling in the nucleus accumbens core
BackgroundGlutamate signaling within the nucleus accumbens underlies motivated behavior and is involved in psychiatric disease. Although behavioral...
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The neuronal and synaptic dynamics underlying post-inhibitory rebound burst related to major depressive disorder in the lateral habenula neuron model
A burst behavior observed in the lateral habenula (LHb) neuron related to major depressive disorder has attracted much attention. The burst is...
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Co-dependent excitatory and inhibitory plasticity accounts for quick, stable and long-lasting memories in biological networks
The brain’s functionality is developed and maintained through synaptic plasticity. As synapses undergo plasticity, they also affect each other. The...
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Linking Inflammation, Aberrant Glutamate-Dopamine Interaction, and Post-synaptic Changes: Translational Relevance for Schizophrenia and Antipsychotic Treatment: a Systematic Review
Evidence from clinical, preclinical, and post-mortem studies supports the inflammatory/immune hypothesis of schizophrenia pathogenesis. Less evident...
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The Coordinating Role of the Actin Cytoskeleton in Short-Term Neural Network Plasticity Involving Excitatory and Inhibitory Synapses
The problem of frequency coding is closely related to studies of the mechanisms by which inhibitory interneurons are involved in neural network...
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Identification of Non-excitatory Amino Acids and Transporters Mediating the Irreversible Synaptic Silencing After Hypoxia
The contribution of excitatory amino acids (AA) to ischemic brain injury has been widely described. In addition, we reported that a mixture of...
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Cortical astrocytes modulate dominance behavior in male mice by regulating synaptic excitatory and inhibitory balance
Social hierarchy is established as an outcome of individual social behaviors, such as dominance behavior during long-term interactions with others....
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A mean-field model of gamma-frequency oscillations in networks of excitatory and inhibitory neurons
Gamma oscillations are widely seen in the cerebral cortex in different states of the wake-sleep cycle and are thought to play a role in sensory...
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Dynamic regulation of excitatory and inhibitory synaptic transmission by growth hormone in the develo** mouse brain
Normal sensory and cognitive function of the brain relies on its intricate and complex neural network. Synaptogenesis and synaptic plasticity are...
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Synchronization and oscillation behaviors of excitatory and inhibitory populations with spike-timing-dependent plasticity
The effect of synaptic plasticity on the synchronization mechanism of the cerebral cortex has been a hot research topic over the past two decades....
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A Non-canonical Excitatory PV RGC–PV SC Visual Pathway for Mediating the Looming-evoked Innate Defensive Response
Parvalbumin-positive retinal ganglion cells (PV + RGCs) are an essential subset of RGCs found in various species. However, their role in transmitting...
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Nonlinear mechanism for the enhanced bursting activities induced by fast inhibitory autapse and reduced activities by fast excitatory autapse
The paradoxical phenomena that excitatory modulation does not enhance but reduces or inhibitory modulation not suppresses but promotes neural firing...
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Abl2 Kinase Differentially Regulates iGluRs Current Activity and Synaptic Localization
Abelson non-receptor tyrosine kinases (Abl1 and Abl2) are established cellular signaling proteins, implicated in cytoskeletal reorganization...
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Effect in the spectra of eigenvalues and dynamics of RNNs trained with excitatory–inhibitory constraint
In order to comprehend and enhance models that describes various brain regions it is important to study the dynamics of trained recurrent neural...
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Induction of excitatory brain state governs plastic functional changes in visual cortical topology
Adult visual plasticity underlying local remodeling of the cortical circuitry in vivo appears to be associated with a spatiotemporal pattern of...
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Abolished ketamine effects on the spontaneous excitatory postsynaptic current of medial prefrontal cortex neurons in GluN2D knockout mice
Ketamine, a non-competitive antagonist of the N -methyl- d -aspartate receptor (NMDAR), generates a rapidly-acting antidepressant effect. It exerts...
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The role of excitatory amino acid transporter 2 (EAAT2) in epilepsy and other neurological disorders
Glutamate is the major excitatory neurotransmitter in the central nervous system (CNS). Excitatory amino acid transporters (EAATs) have important...
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Neuronal excitatory-to-inhibitory balance is altered in cerebral organoid models of genetic neurological diseases
The neuro-physiological properties of individuals with genetic pre-disposition to neurological disorders are largely unknown. Here we aimed to...
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Pre-vs. Post-synaptic Effect
A commonly pursued goal in studying synaptic plasticity is to determine whether synaptic inputs undergo presynaptic and/or postsynaptic alterations...
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PACAP/PAC1-R activation contributes to hyperalgesia in 6-OHDA-induced Parkinson’s disease model rats via promoting excitatory synaptic transmission of spinal dorsal horn neurons
Pain is a common annoying non-motor symptom in Parkinson’s disease (PD) that causes distress to patients. Treatment for PD pain remains a big...
