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Melissa officinalis extract suppresses endoplasmic reticulum stress-induced apoptosis in the brain of hypothyroidism-induced rats exposed to γ-radiation
The purpose of this study was to demonstrate the neuroprotective effect of Melissa officinalis extract (MEE) against brain damage associated with...
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Biological mechanisms and clinical significance of endoplasmic reticulum oxidoreductase 1 alpha (ERO1α) in human cancer
A firm link between endoplasmic reticulum (ER) stress and tumors has been wildly reported. Endoplasmic reticulum oxidoreductase 1 alpha (ERO1α), an...
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Antioxidant System and Endoplasmic Reticulum Stress in Cataracts
The primary underlying contributor for cataract, a leading cause of vision impairment and blindness worldwide, is oxidative stress. Oxidative stress...
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Alteration of Endoplasmic Reticulum Stress
The endoplasmic reticulum (ER) stress is induced by protein misfolding and nutritional deprivation in many eukaryotic cells. Meantime, an imbalance...
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Endoplasmic reticulum stress: a vital process and potential therapeutic target in chronic obstructive pulmonary disease
BackgroundChronic obstructive pulmonary disease (COPD), a chronic and progressive disease characterized by persistent respiratory symptoms and...
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A Ketogenic Diet may Improve Cognitive Function in Rats with Temporal Lobe Epilepsy by Regulating Endoplasmic Reticulum Stress and Synaptic Plasticity
A ketogenic diet (KD) is often used in the treatment of refractory epilepsy. Many studies have found that it also has a positive impact on cognitive...
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ERdj5 protects goblet cells from endoplasmic reticulum stress-mediated apoptosis under inflammatory conditions
Endoplasmic reticulum stress is closely associated with the onset and progression of inflammatory bowel disease. ERdj5 is an endoplasmic...
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Therapeutic potential of endoplasmic reticulum stress inhibitors in the treatment of diabetic peripheral neuropathy
Endoplasmic stress response, the unfolded protein response (UPR), is a homeostatic signaling pathway comprising transmembrane sensors that get...
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The HMGB1-RAGE axis induces apoptosis in acute respiratory distress syndrome through PERK/eIF2α/ATF4-mediated endoplasmic reticulum stress
ObjectiveApoptosis plays a major role in the progression of acute respiratory distress syndrome (ARDS) that may involve the interaction of the high...
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Downregulation of ATF-4 Attenuates the Endoplasmic Reticulum Stress–Mediated Neuroinflammation and Cognitive Impairment in Experimentally Induced Alzheimer’s Disease Model
AbstractProtein aggregation is invariably associated with the inflammation as a factor in Alzheimer’s disease (AD). We investigated the interaction...
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PERK inhibitor, GSK2606414, ameliorates neuropathological damage, memory and motor functional impairments in cerebral ischemia via PERK/p-eIF2ɑ/ATF4/CHOP signaling
The protein kinase R-like endoplasmic reticulum kinase/eukaryotic initiation factor 2ɑ (PERK/eIF2α), the branch of unfolded protein response (UPR),...
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Cutaneous Unfolded Protein Response (UPR) and Endoplasmic Reticulum (ER) Stress
The endoplasmic reticulum (ER) is a fundamental subcellular organelle that regulates cellular protein homeostasis. Within the ER lumen, protein...
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Pharmacological targeting of endoplasmic reticulum stress in disease
The accumulation of misfolded proteins in the endoplasmic reticulum (ER) leads to ER stress, resulting in activation of the unfolded protein response...
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Zinc Accumulation Aggravates Cerebral Ischemia/Reperfusion Injury Through Inducing Endoplasmic Reticulum Stress
Zinc is highly enriched in the central nervous system. Numerous evidences suggest that high concentration of zinc acts as a critical mediator of...
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Interplay Between Oxidative Stress and Endoplasmic Reticulum Stress in the Metastasis of Colon Cancer
Mankind is distressed with various diseases. Cancer is notorious and imposes a huge health burden and affects the quality of life. Colon cancer is...
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Mammalian integrated stress responses in stressed organelles and their functions
The integrated stress response (ISR) triggered in response to various cellular stress enables mammalian cells to effectively cope with diverse...
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CPNE1 regulates myogenesis through the PERK-eIF2α pathway mediated by endoplasmic reticulum stress
Sarcopenia is characterized by a progressive reduction in muscle mass or muscle physiological function associated with aging, but the relevant...
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Curcumin Inhibits Cell Damage and Apoptosis Caused by Thapsigargin-Induced Endoplasmic Reticulum Stress Involving the Recovery of Mitochondrial Function Mediated by Mitofusin-2
Endoplasmic reticulum stress (ERS) and mitochondrial dysfunction have been suggested to relate with the pathology of Alzheimer’s disease (AD)....
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The Role of Endoplasmic Reticulum Stress and NLRP3 Inflammasomes in the Development of Atherosclerosis
AbstractEndoplasmic reticulum (ER) plays a central role in the synthesis of proteins and their post-translational modification by folding newly...
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Amino Acids in Endoplasmic Reticulum Stress and Redox Signaling
Proteins are the chains of amino acids linked via peptide bonds. In cells, newly synthesized proteins are modified and folded in the endoplasmic...