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Designing and Develo** Serological Test for the Diagnosis of Human Fascioliasis Using a New Recombinant Multi-epitope
PurposeFascioliasis is a common parasitic disease in humans and herbivores which is caused by Fasciola hepatica and Fasciola gigantica and has a...
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Prediction and identification of T cell epitopes of COVID-19 with balanced cytokine response for the development of peptide based vaccines
Recent outbreak of 2019 novel Corona virus poses serious challenge for the global health system. In lieu of paucity of experimental data, tools and...
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Designing of multi-epitope peptide vaccine against Acinetobacter baumannii through combined immunoinformatics and protein interaction–based approaches
Acinetobacter baumannii is one of the major pathogenic ESKAPE bacterium, which is responsible for about more than 722,000 cases in a year, globally....
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Molecular analysis reveals a distinct subgenogroup of porcine epidemic diarrhea virus in northern Vietnam in 2018–2019
The spike protein (S) of porcine epidemic diarrhea virus (PEDV), in particular, the C-terminal domain of the S1 subunit (S1-CTD), which contains the...
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Microorganisms in Pathogenesis and Management of Primary Biliary Cholangitis (with Focus on Molecular Mimicry)
Primary biliary cholangitis (PBC) has been considered an enigmatic autoimmune liver disease. The immunopathogenesis of PBC has been considered a...
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Hantaviruses as Emergent Zoonoses: A Global Threat
Hantaviruses are highly zoonotic and present worldwide except in Australia. In humans, this virus produces two major clinical syndromes—in Asian and...
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Pre-clinical characterisation of E2814, a high-affinity antibody targeting the microtubule-binding repeat domain of tau for passive immunotherapy in Alzheimer’s disease
Tau deposition in the brain is a pathological hallmark of many neurodegenerative disorders, including Alzheimer’s disease (AD). During the course of...
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Molecular genotypic analysis of porcine circovirus type 2 reveals the predominance of PCV2d in Vietnam (2018–2020) and the association between PCV2h, the recombinant forms, and Vietnamese vaccines
We conducted nucleotide and amino acid sequence alignment and phylogenetic analysis of porcine circovirus ORF2 (Cap protein) from 17 PCV2-positive...
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Progress towards a glycoconjugate vaccine against Group A Streptococcus
The Group A Carbohydrate (GAC) is a defining feature of Group A Streptococcus (Strep A) or Streptococcus pyogenes . It is a conserved and simple...
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In silico analysis of sporozoite surface antigen 1 of Theileria annulata (TaSPAG1) for multi-epitope vaccine design against theileriosis
Tropical theileriosis is a protozoan infection caused by Theileria annulata , which significantly affects cattle worldwide. This study was aimed to...
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RSV pre-fusion F protein enhances the G protein antibody and anti-infectious responses
Respiratory syncytial virus (RSV) infection in children is the most common viral respiratory infection and can cause severe lung damage or death....
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Phage Display Technology and the Development of Phage-Based Vaccines
A great many phages are amenable to a range of common genetic manipulations. They are also easy to propagate to high numbers and simple to handle....
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The therapeutic landscape of tauopathies: challenges and prospects
Tauopathies are a group of neurodegenerative disorders characterized by the aggregation of the microtubule-associated protein tau. Aggregates of...
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Phylogenoty** of infectious bursal disease virus in Vietnam according to the newly unified genotypic classification scheme
Since 1987, infectious bursal disease virus (IBDV) has circulated and evolved in Vietnam, but little is known about the genotypes present. IBDV...
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Towards development of aptamers that specifically bind to lactate dehydrogenase of Plasmodium falciparum through epitopic targeting
BackgroundEarly detection is crucial for the effective treatment of malaria, particularly in those cases infected with Plasmodium falciparum. There...
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IL-1β Antagonist Receptor Peptide Associated with Photobiomodulation Accelerates Diabetic Wound Tissue Repair
Chronic hyperglycemia caused by diabetes mellitus (DM) slows down the healing process due to prolonged inflammation which impedes the regeneration...
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Fasciola gigantica vaccine construct: an in silico approach towards identification and design of a multi-epitope subunit vaccine using calcium binding EF-hand proteins
Continuous attempts have been made to pinpoint candidate vaccine molecules and evaluate their effectiveness in order to commercialise such vaccines...
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Energetics and IC50 based epitope screening in SARS CoV-2 (COVID 19) spike protein by immunoinformatic analysis implicating for a suitable vaccine development
BackgroundThe recent outbreak by SARS-CoV-2 has generated a chaos in global health and economy and claimed/infected a large number of lives. Closely...
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Crimean-Congo Hemorrhagic Fever Virus, an Emerging and Re-emerging Pathogen of Public Health Concern
Crimean-Congo hemorrhagic fever virus (CCHFV) is a tick-borne zoonosis distributed in Africa, Asia, Eastern Europe, and the Balkans. Humans become...
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Crimean-Congo Hemorrhagic Fever Virus: An Emerging and Re-emerging Pathogen of Public Health Concern
Crimean-Congo hemorrhagic fever virus (CCHFV) is a tick-borne zoonosis distributed in Africa, Asia, Eastern Europe, and the Balkans. Humans become...