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Characterizing Dopamine Transporter Mediated Uptake and Efflux in Brain Slices: A New Approach
The dopamine transporter (DAT) plays a fundamental role in dopamine (DA) neurotransmission by retrieving the transmitter from the extracellular space...
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The ATP-Binding Cassette Transporter-Mediated Efflux Transport of Ganciclovir at the Blood–Brain Barrier
Background and ObjectiveRecent studies have highlighted the key role of the ATP-binding cassette (ABC) transporters, including the P-glycoprotein...
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Generation and characterization of a zebrafish knockout model of abcb4, a homolog of the human multidrug efflux transporter P-glycoprotein
The ATP-binding cassette subfamily B member 1 (ABCB1), encoding a multidrug transporter referred to as P-glycoprotein (Pgp), plays a critical role in...
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Plasmodium falciparum: Transporter and Drug Target
Malaria will continue to be a concern for public health well into the future, as it is responsible for more than 50 million fatalities annually...
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Rejuvenating the Potential of Antimicrobials Via Targeted Therapy of Efflux Pumps: The Advent of Phytotherapeutics
Antimicrobial resistance (AMR) and the emergence of multidrug-resistant organisms are one of the most eminent impediments of recent times. The...
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Combined effects of microplastics and methylmercury on the activity of ATP-binding cassette (ABC) transporter in the brackish water flea Diaphanosoma celebensis
ObjectivesDue to their widespread presence, persistence, and bioaccumulation in living organisms, microplastics (MP) and methylmercury (MeHg)...
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Transport across Membranes: Techniques for Measuring Efflux in Fungal Cells
One of the most prevalent mechanisms of antifungal drug resistance is export of the molecule from the fungal cells through the action of putative...
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Mechanistic Static Model based Prediction of Transporter Substrate Drug-Drug Interactions Utilizing Atorvastatin and Rifampicin
ObjectiveAn in vitro relative activity factor (RAF) technique combined with mechanistic static modeling was examined to predict drug-drug...
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Different Efflux Pump Systems in Acinetobacter baumannii and Their Role in Multidrug Resistance
Several infections, such as pneumonia, urinary tract infections (UTIs), as well as bloodstream, skin, and soft tissue infections, are caused by...
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Natural Product as Efflux Pump Inhibitors Against MRSA Efflux Pumps: An Update
Among different nosocomial infections, Staphylococcus aureus, a Gram-positive bacterium, is a highly adaptive human pathogen. Over the years it had...
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Glutathione transporter as a target for brain drug delivery
Inability to achieve therapeutic concentrations of a medication in the brain due to the blood brain barrier (BBB) is the major cause of treatment...
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CCDC92 promotes podocyte injury by regulating PA28α/ABCA1/cholesterol efflux axis in type 2 diabetic mice
Podocyte lipotoxicity mediated by impaired cellular cholesterol efflux plays a crucial role in the development of diabetic kidney disease (DKD), and...
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Discovery and Development of Monoamine Transporter Ligands
Monoamine transporters (MATs) are targets of a wide range of compounds that have been developed as therapeutic treatments for various...
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The importance of heteroresistance and efflux pumps in bedaquiline-resistant Mycobacterium tuberculosis isolates from Iran
BackgroundTuberculosis (TB) continues to pose a threat to communities worldwide and remains a significant public health issue in several countries....
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Remote Ischaemic Preconditioning Accelerates Brain to Blood Glutamate Efflux via EAATs-mediated Transport
Remote ischaemic conditioning (RIC) becomes an attractive strategy for the endogenous stimulation of mechanisms protecting neurons against ischaemia....
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Somatic SLC30A1 mutations altering zinc transporter ZnT1 cause aldosterone-producing adenomas and primary aldosteronism
Primary aldosteronism (PA) is the most common form of endocrine hypertension and is characterized by inappropriately elevated aldosterone production...
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How Much is Enough? Impact of Efflux Transporters on Drug delivery Leading to Efficacy in the Treatment of Brain Tumors
The lack of effective chemotherapeutic agents for the treatment of brain tumors is a serious unmet medical need. This can be attributed, in part, to...
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Human drug efflux transporter ABCC5 confers acquired resistance to pemetrexed in breast cancer
AimPemetrexed, a new generation antifolate drug, has been approved for the treatment of locally advanced or metastatic breast cancer. However,...
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Non-ionic Surfactants as a P-Glycoprotein(P-gp) Efflux Inhibitor for Optimal Drug Delivery—A Concise Outlook
Significant research efforts have been devoted to unraveling the mystery of P-glycoprotein(P-gp) in drug delivery applications. The efflux membrane...
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Fasting upregulates the monocarboxylate transporter MCT1 at the rat blood-brain barrier through PPAR δ activation
BackgroundThe blood-brain barrier (BBB) is pivotal for the maintenance of brain homeostasis and it strictly regulates the cerebral transport of a...
