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Comparative study on estrogen receptor alpha dimerization and transcriptional activity of parabens
Parabens are used as preservatives in various household products, including oral products, cosmetics, and hair/body washes. In recent years, the...
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The role of EP-2 receptor expression in cervical intraepithelial neoplasia
Prostaglandin induced signalling is involved in different cancers. As previously described, the EP3 receptor expression decreases with increasing...
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Receptor-Binding Specificity of Influenza Viruses
Influenza A virus infection begins with the attachment of virus particles to sialic acid-containing receptors on the surface of host cells. This...
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Role of PGE2 in colonic motility: PGE2 attenuates spontaneous contractions of circular smooth muscle via EP4 receptors in the rat colon
Colonic motor activity is important for the formation and propulsion of feces. The production of prostaglandins (PGs) in colonic tissue is considered...
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Regulation of Heart Contractility by M2 and M3 Muscarinic Receptors: Functional Studies Using Muscarinic Receptor Knockout Mouse
To investigate the functional roles of M2 and M3 muscarinic receptors in mouse atria, wild-type mice, muscarinic M2 or M3 single receptor knockout...
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Progesterone receptor antagonists reverse stem cell expansion and the paracrine effectors of progesterone action in the mouse mammary gland
BackgroundThe ovarian hormones estrogen and progesterone (EP) are implicated in breast cancer causation. A specific consequence of progesterone...
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LAG3 associates with TCR–CD3 complexes and suppresses signaling by driving co-receptor–Lck dissociation
LAG3 is an inhibitory receptor that is highly expressed on exhausted T cells. Although LAG3-targeting immunotherapeutics are currently in clinical...
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Generation of Redirected Engineered Human Chimeric Antigen Receptor (CAR) T Cells
Chimeric antigen receptor (CAR)Chimeric antigen receptor (CAR) T cellT-cell therapy that involves genetic engineeringGenetic engineering a patient’s...
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Eplerenone improves hyperglycemia and sympathetic excitation in chronic renocardiac syndrome in rats
We aimed to assess the efficacy of eplerenone, a steroidal mineralocorticoid receptor antagonist known to reduce blood pressure and mitigate...
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A current review on P2X7 receptor antagonist patents in the treatment of neuroinflammatory disorders: a patent review on antagonists
Chronic inflammation is defined by an activated microglial state linked to all neurological disorders, including Alzheimer’s disease, Parkinson’s...
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Comparative Proteomics Analysis Reveals Distinct Molecular Phenotype and Biomarkers in Patients with Erythrodermic Atopic Dermatitis and Erythrodermic Psoriasis
Erythrodermic atopic dermatitis (EAD) and erythrodermic psoriasis (EP) are rare yet debilitating inflammatory skin disorders that propose challenges...
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Characteristics of A-type voltage-gated K+ currents expressed on sour-sensing type III taste receptor cells in mice
Sour taste is detected by type III taste receptor cells that generate membrane depolarization with action potentials in response to HCl applied to...
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LncRNA-UC.25 + shRNA Alleviates P2Y14 Receptor–Mediated Diabetic Neuropathic Pain via STAT1
Diabetic neuropathic pain (DNP) is a common complication of diabetes, and its complicated pathogenesis, as well as clinical manifestations, has...
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Molecular classification and biomarkers of outcome with immunotherapy in extensive-stage small-cell lung cancer: analyses of the CASPIAN phase 3 study
BackgroundWe explored potential predictive biomarkers of immunotherapy response in patients with extensive-stage small-cell lung cancer (ES-SCLC)...
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The role of triggering receptor expressed on myeloid cells-1 (TREM-1) in central nervous system diseases
Triggering receptor expressed on myeloid cells-1 (TREM-1) is a member of the immunoglobulin superfamily and is mainly expressed on the surface of...
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Depleting receptor tyrosine kinases EGFR and HER2 overcomes resistance to EGFR inhibitors in colorectal cancer
BackgroundEpidermal growth factor receptor (EGFR) inhibitors, including cetuximab and panitumumab, are valuable therapeutics for colorectal cancer...
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Efficacy evaluation of chimeric antigen receptor-modified human peritoneal macrophages in the treatment of gastric cancer
BackgroundGastric cancer is one of the most common cancers. Peritoneal carcinomatosis (PC) appears to be the most common pattern of recurrence, and...
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Angiotensin II Type 2 Receptor Inhibits M1 Polarization and Apoptosis of Alveolar Macrophage and Protects Against Mechanical Ventilation-Induced Lung Injury
Angiotensin II (Ang II) is associated with macrophage polarization and apoptosis, but the role of the angiotensin type 2 receptor (AT2R) in these...
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The Neuroprotective Effects of Administration of Methylprednisolone in Cardiopulmonary Resuscitation in Experimental Cardiac Arrest Model
Although advances in diagnosis and treatment of cardiac arrest (CA) could improve neurological outcomes after cardiopulmonary resuscitation (CPR),...
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Glucocorticoid receptor modulates myeloid-derived suppressor cell function via mitochondrial metabolism in immune thrombocytopenia
Myeloid-derived suppressor cells (MDSCs) are a heterogeneous population of immature cells and natural inhibitors of adaptive immunity. Intracellular...
