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The Wnt/β-catenin signaling pathway plays a role in drug-induced liver injury by regulating cytochrome P450 2E1 expression
Drug-induced liver injury (DILI) is a major cause of acute liver failure and drug withdrawal. Cytochrome P450 (CYP) 2E1 is involved in the metabolism...
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Selective androgen receptor modulator use and related adverse events including drug-induced liver injury: Analysis of suspected cases
PurposeSelective androgen receptor modulators (SARMs) have demonstrated agonist activity on the androgen receptor in various tissues, stimulating...
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The application of cytokeratin-18 as a biomarker for drug-induced liver injury
Drug-induced liver injury (DILI) is a frequent and dangerous adverse effect faced during preclinical and clinical drug therapy. DILI is a leading...
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The potential liver injury induced by metronidazole-provoked disturbance of gut microbiota: modulatory effect of turmeric supplementation
It has been reported that the gut-liver axis and intestinal microbiome contribute crucially to different liver diseases. So, targeting this...
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Exploiting urine-derived induced pluripotent stem cells for advancing precision medicine in cell therapy, disease modeling, and drug testing
The field of regenerative medicine has witnessed remarkable advancements with the emergence of induced pluripotent stem cells (iPSCs) derived from a...
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Extracellular Vesicles and Fatty Liver
Fatty liver is a complex pathological process caused by multiple etiologies. In recent years, the incidence of fatty liver has been increasing year...
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FGL1 and FGL2: emerging regulators of liver health and disease
Liver disease is a complex group of diseases with high morbidity and mortality rates, emerging as a major global health concern. Recent studies have...
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State-of-the-art liver disease research using liver-on-a-chip
To understand disease pathophysiologies, models that recapitulate human functions are necessary. In vitro models that consist of human cells are...
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Advances in Exosome-Based Therapies for the Repair of Peripheral Nerve Injuries
Peripheral nerve injuries (PNIs) are the term used to describe injuries that occur to the nerve fibers of the peripheral nervous system (PNS). Such...
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Drug induced liver injury: an update
Drug induced liver injury (DILI) is a relatively rare hepatic condition in response to the use of medications, illegal drugs, herbal products or...
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Targeting ferroptosis: a novel insight against myocardial infarction and ischemia–reperfusion injuries
Ferroptosis, a newly discovered form of regulated cell death dependent on iron and reactive oxygen species, is mainly characterized by mitochondrial...
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Bipotent transitional liver progenitor cells contribute to liver regeneration
Following severe liver injury, when hepatocyte-mediated regeneration is impaired, biliary epithelial cells (BECs) can transdifferentiate into...
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Albiflorin Alleviates Severe Acute Pancreatitis-Associated Liver Injury by Inactivating P38MAPK/NF-κB Signaling Pathway
Albiflorin (Alb) is a monoterpenoid component that is commonly found in Paeonia lactiflora Pall . or Paeonia veitchii Lynch . It is known for its...
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Targeting cAMP signaling and phosphodiesterase 4 for liver disease treatment
Liver disease is a significant health burden globally and accounts for 4% of total deaths annually. Alcoholic liver disease (ALD) and...
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The liver in sepsis: molecular mechanism of liver failure and their potential for clinical translation
Liver failure is a life-threatening complication of infections restricting the host's response to infection. The pivotal role of the liver in...
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Tumor necrosis factor-inducible gene 6 protein and its derived peptide ameliorate liver fibrosis by repressing CD44 activation in mice with alcohol-related liver disease
BackgroundAlcohol-related liver disease (ALD) is a major health concern worldwide, but effective therapeutics for ALD are still lacking. Tumor...
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Therapeutic approaches for cholestatic liver diseases: the role of nitric oxide pathway
Cholestasis describes bile secretion or flow impairment, which is clinically manifested with fatigue, pruritus, and jaundice. Neutrophils play a...
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SARS-CoV-2-mediated liver injury: pathophysiology and mechanisms of disease
BackgroundSARS-CoV-2-induced severe inflammatory response can be associated with severe medical consequences leading to multi-organ failure,...
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Liver fibrosis pathologies and potentials of RNA based therapeutics modalities
Liver fibrosis (LF) occurs when the liver tissue responds to injury or inflammation by producing excessive amounts of scar tissue, known as the...
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Contribution of Humanized Liver Chimeric Mice to the Study of Human Hepatic Drug Transporters: State of the Art and Perspectives
Chimeric mice with humanized livers constitute an attractive emergent experimental model for investigating human metabolism and disposition of drugs....
