Search
Search Results
-
An integrated framework for prognosis prediction and drug response modeling in colorectal liver metastasis drug discovery
BackgroundColorectal cancer (CRC) is the third most prevalent cancer globally, and liver metastasis (CRLM) is the primary cause of death. Hence, it...
-
Impact of Genetic Variation on Drug Response
Pharmacogenomics investigates the influence of genetics on drug response, with the ultimate aim of giving patients the right drug at the right dose...
-
Prediction of drug–drug interactions between roflumilast and CYP3A4/1A2 perpetrators using a physiologically-based pharmacokinetic (PBPK) approach
This study aimed to develop a physiologically-based pharmacokinetic (PBPK) model to predict changes in the pharmacokinetics (PK) and pharmacodynamics...
-
Deep learning infers clinically relevant protein levels and drug response in breast cancer from unannotated pathology images
The computational pathology has been demonstrated to effectively uncover tumor-related genomic alterations and transcriptomic patterns. Although...
-
Do genetics contribute to TNF inhibitor response prediction in Psoriatic Arthritis?
Psoriatic arthritis (PsA) is a heterogeneous chronic musculoskeletal disease, affecting up to 30% of people with psoriasis. Research into PsA...
-
Ex vivo drug sensitivity screening predicts response to temozolomide in glioblastoma patients and identifies candidate biomarkers
BackgroundPatient-derived glioma stem-like cells (GSCs) have become the gold-standard in neuro-oncological research; however, it remains to be...
-
Cancer organoid-based diagnosis reactivity prediction (CODRP) index-based anticancer drug sensitivity test in ALK-rearrangement positive non-small cell lung cancer (NSCLC)
BackgroundRecently, cancer organoid-based drug sensitivity tests have been studied to predict patient responses to anticancer drugs. The area under...
-
Molecular Dynamics Simulation-Based Prediction of Glycosaminoglycan Interactions with Drug Molecules
Glycosaminoglycans (GAGs) are a class of long linear anionic periodic polysaccharides. Their biological activities are very broad including tissue...
-
Drug-Drug and Food-Drug Interactions of Pharmacokinetic Nature
The most relevant pharmacokinetic mechanisms of drug-drug (DD) and food-drug (FD) interactions are summarized from a perspective that will allow the...
-
Drug-resistant profiles of extracellular vesicles predict therapeutic response in TNBC patients receiving neoadjuvant chemotherapy
BackgroundPredicting tumor responses to neoadjuvant chemotherapy (NAC) is critical for evaluating prognosis and designing treatment strategies for...
-
Prediction of the First-Pass Metabolism of a Drug After Oral Intake Based on Structural Parameters and Physicochemical Properties
Background and ObjectiveThe oral first-pass metabolism is a crucial factor that plays a key role in a drug’s pharmacokinetic profile. Prediction of...
-
Application of Solubility and Dissolution Profile Comparison for Prediction of Gastric pH-Mediated Drug-Drug Interactions
The objective of this study was to assess how solubility and dissolution profile comparisons under different pH conditions can be used to predict...
-
Predicting breast cancer drug response using a multiple-layer cell line drug response network model
BackgroundPredicting patient drug response based on a patient’s molecular profile is one of the key goals of precision medicine in breast cancer...
-
Characterization of protein cargo of Echinococcus granulosus extracellular vesicles in drug response and its influence on immune response
BackgroundThe Echinococcus granulosus sensu lato species complex causes cystic echinococcosis, a zoonotic disease of medical importance....
-
Prediction of CAF-related genes in immunotherapy and drug sensitivity in hepatocellular carcinoma: a multi-database analysis
This study aims to identify the cancer-associated fibroblasts (CAF)-related genes that can affect immunotherapy and drug sensitivity in...
-
“Proteotranscriptomic analysis of advanced colorectal cancer patient derived organoids for drug sensitivity prediction”
BackgroundPatient-derived organoids (PDOs) from advanced colorectal cancer (CRC) patients could be a key platform to predict drug response and...
-
Network Pharmacology for Drug Repositioning in Anti-Alzheimer’s Drug Development
Alzheimer’s disease (AD) has become a public health emergency due to its complexity and heterogeneity; therefore, therapeutic regimens must focus on...
-
3D tumor spheroids: morphological alterations a yardstick to anti-cancer drug response
Tumor spheroids are one of the well-characterized 3D culture systems bearing close resemblance to the physiological tissue organization and...
-
Multi-omics approaches for drug-response characterization in primary biliary cholangitis and autoimmune hepatitis variant syndrome
BackgroundPrimary biliary cholangitis (PBC) and autoimmune hepatitis (AIH) variant syndrome (VS) exhibit a complex overlap of AIH features with PBC,...
-
Development of a TLR-Based Model That Can Predict Prognosis, Tumor Microenvironment, and Drug Response for Esophageal Squamous Cell Carcinoma
The toll-like receptor (TLR) family is an important class of proteins involved in the immune response. However, little is known about the association...
