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Dose Range Finding (DRF) Studies in Drug Toxicology Assessments
Early repeated dose-range finding (DRF) toxicology studies, usually conducted in rodent and non-rodent animal species, seek to provide the earliest...
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Introducing new plan evaluation indices for prostate dose painting IMRT plans based on apparent diffusion coefficient images
BackgroundDose painting planning would be more complicated due to different levels of prescribed doses and more complex evaluation with conventional...
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Dosimetric comparison of two dose expansion methods in intensity modulated radiotherapy for breast cancer
BackgroundTo explore the dosimetric difference between IMRT-VB plan based on the establishment of external expansion structure and virtual bolus (VB)...
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Two weeks dose range-finding and four weeks repeated dose oral toxicity study of a novel reversible monoamine oxidase B inhibitor KDS2010 in cynomolgus monkeys
A novel reversible monoamine oxidase B inhibitor, KDS2010, has been developed as a therapeutic candidate for neurodegenerative diseases. This study...
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Dosimetric effect of respiratory motion on planned dose in whole-breast volumetric modulated arc therapy using moderate and ultra-hypofractionation
Background and purposeThe interplay effect of respiratory motion on the planned dose in free-breathing right-sided whole-breast irradiation (WBI)...
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Influence of target dose heterogeneity on dose sparing of normal tissue in peripheral lung tumor stereotactic body radiation therapy
ObjectiveTo evaluate the influence of target dose heterogeneity on normal tissue dose sparing for peripheral lung tumor stereotactic body radiation...
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Fixed-dose combination therapy for the prevention of atherosclerotic cardiovascular disease
Fixed-dose combination (FDC) therapy, also known as polypill therapy, targets risk factors for atherosclerotic cardiovascular disease (ASCVD) and has...
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Low-dose PLX5622 treatment prevents neuroinflammatory and neurocognitive sequelae after sepsis
BackgroundSepsis-associated encephalopathy (SAE) is characterized by symptoms of delirium including hallucinations, impaired concentration,...
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Comparison of skin dose in IMRT and VMAT with TrueBeam and Halcyon linear accelerator for whole breast irradiation
With the increasing use of flattening filter free (FFF) beams, it is important to evaluate the impact on the skin dose and target coverage of breast...
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Safety of the Drug Prospekta: a Preclinical Study of Acute and Repeated Dose Toxicity
General toxic effect of the drug Prospekta (modified affinity purified antibodies to the brain-specific S100 protein) was studied on mature male and...
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Use of Resonant Acoustic Mixing Technology for Ultra-Low-Dose Blending in a Single-Step Mixing Process
PurposeTo evaluate the use of resonant acoustic mixing (RAM) technology for homogenous blending of a morphologically challenging model API in...
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Dose–effect relationship of stereotactic body radiotherapy in non-small cell lung cancer patients
ObjectiveTo establish the dose effect relationship between the dose parameters of stereotactic body radiation therapy (SBRT) for early non-small cell...
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Protective antibody threshold of RTS,S/AS01 malaria vaccine correlates antigen and adjuvant dose in mouse model
Mouse models are useful for the early down-selection of malaria vaccine candidates. The Walter Reed Army Institute of Research has optimized a...
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Pretreatment patient-specific quality assurance prediction based on 1D complexity metrics and 3D planning dose: classification, gamma passing rates, and DVH metrics
PurposeHighly modulated radiotherapy plans aim to achieve target conformality and spare organs at risk, but the high complexity of the plan may...
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Examination of conversion method of dose distribution of lung cancer IMRT using fluence reversible calculation function in O-ring type linac and C-type linac
Generally, converting irradiation plans between C-arm linacs (C-linac) when the linac fails is possible without recalculating the dose distribution...
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Repeated-dose toxicity and toxicokinetic study of isobutylparaben in rats subcutaneously treated for 13 weeks
Parabens have historically served as antimicrobial preservatives in a range of consumables such as food, beverages, medications, and personal care...
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Double enhancement effect of a surface dose with tungsten rubber bolus in photon radiotherapy for keloids and superficial tumors
To clarify the dosimetric characteristics of a real-time variable shape rubber-containing tungsten (STR) bolus in a clinical plan and investigate the...
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Adaptive dose escalated radiotherapy in oropharyngeal cancers: a treatment planning feasibility study
BackgroundA significant proportion of patients with poor prognosis squamous cell cancer of the oropharynx relapse loco-regionally despite radical...
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Toxicokinetics of praseodymium and cerium administered as chloride salts in Sprague–Dawley rats: impacts of the dose and of co-exposure with additional rare earth elements
We conducted a rat exposure study to assess the impacts of dose and co-exposure with other rare earth elements (REEs) on the toxicokinetics of...
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Estimating cancer risks due to whole lungs low dose radiotherapy with different techniques for treating COVID-19 pneumonia
BackgroundLow dose radiotherapy (LDRT) of whole lungs with photon beams is a novel method for treating COVID-19 pneumonia. This study aimed to...
