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The Endolysosomal Transporter DMT1 is Required for Morphine Regulation of Neuronal Ferritin Heavy Chain
NeuroHIV and other neurologic disorders present with altered iron metabolism in central nervous system neurons. Many people with HIV also use...
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HMGB1 Mediates Inflammation-Induced DMT1 Increase and Dopaminergic Neurodegeneration in the Early Stage of Parkinsonism
Both neuroinflammation and iron accumulation play roles in the pathogenesis of Parkinson’s disease (PD). However, whether inflammation induces iron...
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Dysfunction of DMT1 and miR-135b in the gut-testis axis in high-fat diet male mice
BackgroundObese patients have been found to be susceptible to iron deficiency, and malabsorption of dietary iron is the cause of obesity-related iron...
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Estrogen Up-Regulates Iron Transporters and Iron Storage Protein Through Hypoxia Inducible Factor 1 Alpha Activation Mediated by Estrogen Receptor β and G Protein Estrogen Receptor in BV2 Microglia Cells
Estrogen is a steroid hormone produced mainly by the ovaries. It has been found that estrogen could regulate iron metabolism in neurons and...
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Metal Chelators as a Potential Therapeutic Agent for Alzheimer’s Disease
Alzheimer’s disease (AD) is a neurological condition that causes behavioural abnormalities and a progressive decline in intellectual abilities....
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Amelioration of White Matter Injury Through Mitigating Ferroptosis Following Hepcidin Treatment After Spinal Cord Injury
Spinal cord injury (SCI) usually introduces permanent or long-lasting neurological impairments. Maintaining the integrity of the limited number of...
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Diabetic Cardiomyopathy and Cell Death: Focus on Metal-Mediated Cell Death
Cardiac myocyte death is an essential initiator of the pathogenesis and progression of various etiological cardiomyopathies, including diabetic...
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The Role of Iron Metabolism in Sepsis-associated Encephalopathy: a Potential Target
Sepsis-associated encephalopathy (SAE) is an acute cerebral dysfunction secondary to infection, and the severity can range from mild delirium to deep...
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COVID-19-induced neurological symptoms: focus on the role of metal ions
Neurological symptoms are prevalent in both the acute and post-acute phases of coronavirus disease 2019 (COVID-19), and they are becoming a major...
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A State-of-the-Science Review on Metal Biomarkers
Purpose of ReviewBiomarkers are commonly used in epidemiological studies to assess metals and metalloid exposure and estimate internal dose, as they...
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Ferroptosis contributing to cardiomyocyte injury induced by silica nanoparticles via miR-125b-2-3p/HO-1 signaling
BackgroundAmorphous silica nanoparticles (SiNPs) have been gradually proven to threaten cardiac health, but pathogenesis has not been fully...
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Comparison of apical and basolateral Cu treatment for iron-related gene regulation during deferoxamine induced iron deficiency
BackgroundIntestinal copper transporter (Atp7a) mutant-brindled mice with systemic Cu deficiency had elevated Cu levels in enterocyte cells without...
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Molecular Mechanisms of Metal-Induced Carcinogenesis
Occupational and environmental exposures to metals are strongly associated with an increased risk of various cancers. Although carcinogenesis caused...
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Protective Effect of Sevoflurane Preconditioning on Cardiomyocytes Against Hypoxia/Reoxygenation Injury by Modulating Iron Homeostasis and Ferroptosis
To investigate the mechanism whereby sevoflurane (Sev) protects cardiomyocytes from hypoxia/reoxygenation (H/R) injury. The rat cardiomyocyte line...
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TRPM7 channel activity in Jurkat T lymphocytes during magnesium depletion and loading: implications for divalent metal entry and cytotoxicity
TRPM7 is a cation channel-protein kinase highly expressed in T lymphocytes and other immune cells. It has been proposed to constitute a cellular...
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HIV-1 gp120-Induced Endolysosome de-Acidification Leads to Efflux of Endolysosome Iron, and Increases in Mitochondrial Iron and Reactive Oxygen Species
The HIV-1 coat protein gp120 continues to be implicated in the pathogenesis of HIV-1 associated neurocognitive disorder (HAND); a condition known to...
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Extracellular α-Synuclein Modulates Iron Metabolism Related Proteins via Endoplasmic Reticulum Stress in MES23.5 Dopaminergic Cells
Alpha-synuclein plays a vital role in the pathology of Parkinson’s disease (PD). Spreading of α-synuclein in neighboring cells was believed to...
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Intracellular Iron Accumulation Induces Inflammatory and Oxidative Status of the Host After Japanese Encephalitis Viral Infection
The factors mitigating the microglia/macrophage activation and inflammatory damage in Japanese encephalitis (JE) virus infected CNS are still being...
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The Mechanisms of Ferroptosis Under Hypoxia
Ferroptosis is a new form of programmed cell death, which is characterized by the iron-dependent accumulation of lipid peroxidation and increase of...
