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Dioscin alleviates the progression of osteoarthritis: an in vitro and in vivo study
Osteoarthritis (OA) is a common joint disease and is the main cause of physical disability in the elderly. Currently, there is no adequate...
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Preventive effect of dioscin against monosodium urate-mediated gouty arthritis through inhibiting inflammasome NLRP3 and TLR4/NF-κB signaling pathway activation: an in vivo and in vitro study
Monosodium urate (MSU)-mediated inflammation is closely related to gouty arthritis (GA). Dioscin, an active ingredient, has been reported to possess...
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Selectivity and potency of natural product PIM kinase inhibitors identified by in silico docking
PIM3 (Proviral Integration site for Maloney murine leukemia virus kinase 3) is a proto-oncogene with serine/threonine kinase activity that prevents...
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Correction to: Protective effects of dioscin against alcohol‑induced liver injury
During the course of writing and revision of this paper, the band of GAPDH.
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Dioscin
Dioscin is extracted from Dioscorea nipponica Thunb. It has therapeutic effects on reducing blood lipids and protecting the liver, as well as...
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Dynamic profiling of medulloblastoma surfaceome
Medulloblastoma (MB) is the most common type of malignant pediatric brain cancer. The current standard of care (SOC) involves maximal safe resection...
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Diosgenin, a steroidal sapogenin, arrests arthritis through modulation of inflammatory cytokines and oxidative stress biomarkers in Wistar rats
Diosgenin (DGN) is a well-known steroidal sapogenin that is obtained from the hydrolysis of dioscin. The current research aimed to explore the...
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The modulation of sirtuins by natural compounds in the management of cisplatin-induced nephrotoxicity
Cisplatin is a highly effective antitumor agent. However, its use is limited due to severe adverse effects, particularly nephrotoxicity, which occurs...
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Preventive and therapeutic use of herbal compounds against doxorubicin induced hepatotoxicity: a comprehensive review
Doxorubicin (DOX) is associated with numerous acute and chronic dose-related toxicities including hepatotoxicity. This adverse reaction may limit the...
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Dioscin-6’-O-acetate impairs migration of lung cancer cells through attenuations of MMP-2 and MMP-9 via NF-κB suppression
More than 90% of the cancer-associated mortality is attributed to its metastasis. Numerous studies demonstrated that natural steroidal saponins from...
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Phytochemical Extract from Carica papaya Leaves and Punica granatum Seeds as Therapy Against Cognitive Impairment in a Murine Model
Mild cognitive impairment (MCI) is defined as inter-stage between normal cognitive aging and major neurocognitive disorder (MND). This state of decay...
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The Pharmacokinetics and Tissue Distributions of Nine Steroidal Saponins from Paris polyphylla in Rats
Background and ObjectivesParis polyphylla ( P. polyphylla ) is a herb widely used in traditional Chinese medicine to treat various diseases. This...
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An integrated approach to elucidate signaling pathways of dioscin-induced apoptosis, energy metabolism and differentiation in acute myeloid leukemia
Although the therapeutics have improved the rates of remission and cure of acute myelogenous leukemia (AML) in recent decades, there is still an...
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Pyroptosis in bone loss
Pyroptosis could be responsible for the bone loss from bone metabolic diseases, leading to the negative impact on people's health and life. It has...
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Herbal Approaches for the Management of Neurological Disorders
Neurological disorder like epilepsy, Alzheimer’s, and Parkinson’s disease is manifested by extensive morbidity, disability, along high rate of...
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Nanocarrier-Mediated Drug Delivery via Inhalational Route for Lung Cancer Therapy: A Systematic and Updated Review
Lung cancer is one of the most severe lethal malignancies, with approximately 1.6 million deaths every year. Lung cancer can be broadly categorised...
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Phenols and terpenoids: natural products as inhibitors of NLRP3 inflammasome in cardiovascular diseases
Inflammatory infiltration has been implicated in the pathogenesis of cardiovascular diseases (CVDs). The NLRP3 inflammasome is involved in the...
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Modulators of ROS/NF-κB Signaling in Cancer Therapy
Oxidative stress regulates NF-κB signaling pathway and induces the transcription of genes related to apoptosis and cell proliferation. Due to its...
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Modulators of ROS/NF-κB Signaling in Cancer Therapy
Oxidative stress regulates NF-κB signaling pathway and induces the transcription of genes related to apoptosis and cell proliferation. Due to its...
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The role of the farnesoid X receptor in kidney health and disease: a potential therapeutic target in kidney diseases
The prevalence of kidney diseases has been increasing worldwide due to the aging population and has results in an increased socioeconomic burden as...
