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Biomedicine

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Showing 1-11 of 11 results

  1. Exploring novel dilazep derivatives as hENT1 inhibitors and potentially covalent molecular tools

    The human equilibrative nucleoside transporter 1 (SLC29A1, hENT1) is a solute carrier that modulates the passive transport of nucleosides and...

    Majlen A. Dilweg, Marina Gorostiola González, ... Daan van der Es in Purinergic Signalling
    Article Open access 15 June 2024

  2. Repurposing Approved Drugs as Inhibitors of Kv7.1 and Nav1.8 to Treat Pitt Hopkins Syndrome

    Purpose

    Pitt Hopkins Syndrome (PTHS) is a rare genetic disorder caused by mutations of a specific gene, transcription factor 4 (TCF4), located on...

    Sean Ekins, Jacob Gerlach, ... Aaron Gerlach in Pharmaceutical Research
    Article 22 July 2019

  3. Epidermolysis bullosa and the partnership with autoimmunity: what should we assimilate?

    Bullous skin diseases are characterized by genetic abnormalities related to structural epidermal proteins or organ-specific autoantibodies against...

    Susanna Esposito, Sophie Guez, ... Donato Rigante in Immunologic Research
    Article 21 November 2014

  4. Special Senses

    There is substantial involvement of purinergic signalling in the physiology of the special senses and this will be considered in the eye, inner ear,...
    Geoffrey Burnstock, Alexei Verkhratsky in Purinergic Signalling and the Nervous System
    Chapter 2012

  5. D

    Ian K. M. Morton, Judith M. Hall in Concise Dictionary of Pharmacological Agents
    Chapter 1999

  6. Effect of dilazep dihydrochloride against ischemia and reperfusion-induced disruption of blood-brain barrier in rats: a quantitative study

    The effect of dilazep dihydrochloride (dilazep) against ischemia and reperfusion-induced disruption of blood-brain barrier (BBB) was quantitatively...

    Jun-ichi Kawagoe, Koji Abe, ... Kyuya Kogure in Naunyn-Schmiedeberg's Archives of Pharmacology
    Article 01 April 1992

  7. [3H]R75231 — a new radioligand for the nitrobenzylthioinosine sensitive nucleoside transport proteins Characterization of (±)-[3H]R75231 binding to calf lung membranes, stereospecificity of its two stereoisomers, and comparison with [3H]nitrobenzylthioinosine binding

    The tritiated analogue of R75231 ((±)-2-(aminocarbonyl)-N-(4-amino-2,6-dichlorophenyl)-4-[5,5-bis(4-fluorophenyl)pentyl]-1-piperazineacetamide) has...

    Adriaan P. IJzerman, Marieke Kruidering, ... Cor Janssen in Naunyn-Schmiedeberg's Archives of Pharmacology
    Article 01 May 1992

  9. Effects of antiarrhythmic drugs on the extraneuronal accumulation of isoprenaline in perfused rat hearts

    The effects of class I, II, III and IV antiarrhythmic drugs (as classified by Vaughan Williams 1974), tetrodotoxin and β 2 -adrenoceptor antagonists...

    Kazumi Sono, Yoshinobu Akimoto, ... Motohatsu Fujiwara in Naunyn-Schmiedeberg's Archives of Pharmacology
    Article 01 October 1986

  11. Review of the literature

    Lucie Schlosser in Archives of Toxicology
    Article 01 December 1975
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